| EMG Solicitors Limited | Professional & scientific | 2013 |
| EML Risk Management Limited | Professional & scientific | 2017 |
| Emmajaynepublichouse Ltd | Wholesale & retail | 2024 |
| Emmanuel Church Durham | Other services | 2007 |
| Emmv Limited | Information & communication | 2025 |
| Emotion Property Ltd | Extraterritorial | 2017 |
| Empire Crust Ltd | Hospitality | 2025 |
| Empire Fade Ltd | Other services | 2024 |
| Empowerfulpeople Ltd | Professional & scientific | 2020 |
| Empowermama CIC | Health & social care | 2026 |
| Empowher Northeast C.I.C. | Health & social care | 2021 |
| ENA Management Solutions Limited | Professional & scientific | 2010 |
| Enache Transport Ltd | Transport & logistics | 2025 |
| Enchantedcoco Limited | Wholesale & retail | 2025 |
| END of Life Learning Hub CIC | Education | 2026 |
| END to END Financial Solutions Limited | Professional & scientific | 2009 |
| Endeavour Training & Consultancy Limited | Education | 2013 |
| Ener-G BIO Ltd. | Other services | 2016 |
| Energist Property Holdings Limited | Construction | 2022 |
| Energize Wind Limited | Other services | 2024 |
| Energy for Business (UK) Limited | Other services | 2000 |
| Energy Optimisation Ltd | Professional & scientific | 2020 |
| Energy Procurement Organisation Ltd | Professional & scientific | 2018 |
| ENERGY4YOU Limited | Professional & scientific | 2008 |
| Enga Limited | Agriculture & fishing | 1989 |
| Engage-N-Change Ltd | Professional & scientific | 2017 |
| Enginous Solutions Ltd | Wholesale & retail | 2011 |
| Enkinisi Limited | Health & social care | 2020 |
| Enter C.I.C. | Education | 2010 |
| Envasantham Care Ltd | Health & social care | 2025 |
| Enviro UK Consultants Limited | Professional & scientific | 2013 |
| EOS Promotions Ltd | Wholesale & retail | 2019 |
| Epoque Films | | 2010 |
| Epoxy Groundworks Ltd | Construction | 2026 |
| EPR Contracts Limited | Construction | 2018 |
| EPR Developments Limited | Real estate | 2023 |
| EPR Group Holdings Limited | Financial services | 2023 |
| EPS Joinery Limited | Construction | 2025 |
| Eqify Ltd | Professional & scientific | 2026 |
| Equistone Vista Ltd | Real estate | 2025 |
| Equity Accounting (NE) LLP | | 2023 |
| Equivolt Ltd | Manufacturing | 2025 |
| Eqweighty Training Limited | Education | 2026 |
| Ermarkt-Uk Ltd | Wholesale & retail | 2025 |
| Errington Anaesthetics Limited | Health & social care | 2009 |
| Ersmark Limited | Wholesale & retail | 2025 |
| ES Child Care Limited | Administrative & support | 2009 |
| Escape Rooms Lumley Ltd | Arts & recreation | 2018 |
| ESH Chilton Moor Ltd | Construction | 2019 |
| ESH DBC Ltd | Construction | 2019 |
| ESH EBT Trustee Limited | Professional & scientific | 2005 |
| ESH Homes Limited | Construction | 2014 |
| ESH Investments Limited | Construction | 2014 |
| ESH Plumbing Services Ltd | Construction | 2013 |
| ESH Salutation Road Limited | Construction | 2017 |
| ESH Space the Park Limited | Construction | 2007 |
| ESH Stantec Limited | Construction | 2015 |
| Esnglobal Ltd | Wholesale & retail | 2025 |
| Essence Estates NE Ltd | Administrative & support | 2025 |
| Essex and Suffolk Water Limited | Professional & scientific | 1991 |
| Estate FX Limited | Real estate | 2021 |
| Estate Marketing Services Ltd | Professional & scientific | 2024 |
| Etatech Limited | Professional & scientific | 2000 |
| Ethical Energy NE Ltd | Administrative & support | 2017 |
| Ethicare (Durham) Ltd | Health & social care | 2014 |
| EU Roads Ltd | Construction | 2026 |
| Eureka Mews Management Company Limited | Real estate | 2005 |
| Euro Land Developments Limited | Construction | 2020 |
| Eurocatering (N.E.) Limited | Administrative & support | 2007 |
| European Engineering Consultancy Limited | Extraterritorial | 1997 |
| European Group Holdings Ltd | Financial services | 2025 |
| European Group Investments Ltd | Financial services | 2025 |
| European Group Real Estate Ltd | Financial services | 2025 |
| European Group Services Ltd | Financial services | 2025 |
| European Travel Group Ltd | Transport & logistics | 2015 |
| Eva's Bella Ltd | Hospitality | 2025 |
| Evanstone Energy Ltd | Wholesale & retail | 2026 |
| Evenmore Properties Limited | Real estate | 2017 |
| Eventertainment North East Ltd | Hospitality | 2023 |
| Events North East Ltd | Hospitality | 2026 |
| Everbrit Global Ltd | Wholesale & retail | 2025 |
| Evergreen Park Limited | Real estate | 2004 |
| Everstead Trading Ltd | Wholesale & retail | 2025 |
| Everyday Publisher Ltd | Information & communication | 2024 |
| Everyone Knows Dave Limited | Professional & scientific | 2013 |
| Evidence Based Risk Ltd | Health & social care | 2011 |
| Evie Black Occasion Wear Ltd | Wholesale & retail | 2020 |
| Evimeria Ltd | Real estate | 2021 |
| Evolution Advisory and Accounting Limited | Professional & scientific | 2018 |
| Evolve North Limited | Information & communication | 2004 |
| Evotune Limited | Wholesale & retail | 2009 |
| Excellence Home Care Ltd | Professional & scientific | 2019 |
| Excellence Investment & Development Ltd | Construction | 2015 |
| Exclamation Mark Studio Ltd | Arts & recreation | 2025 |
| Executive Country Homes Limited | Construction | 2006 |
| Exige Projects Ltd | Other services | 2016 |
| Expert Fire Solutions Limited | Professional & scientific | 2013 |
| Expert Shutters and Blinds Ltd | Construction | 2025 |
| Exploration & Testing Associates Limited | Construction | 2019 |
| Exportwise Ltd | Wholesale & retail | 2024 |