| Datavana Ltd | Information & communication | 2024 |
| Datavyse Ltd | Information & communication | 2025 |
| Dave Allan Fireplaces Limited | Wholesale & retail | 2004 |
| Dave Hooli Ltd | Administrative & support | 2023 |
| Dave T Barr Consulting Ltd | Information & communication | 2024 |
| David Beswick Construction Ltd | Construction | 2014 |
| David Carr (Durham) Limited | Construction | 2009 |
| David Coulson Construction Limited | Construction | 2008 |
| David Parsons Limited | Construction | 2000 |
| David Thorns (Civil Engineering) Limited | Construction | 1997 |
| Davidson Pharmacy Limited | Wholesale & retail | 1995 |
| Davison Construction and Civils Limited | Construction | 2009 |
| Davut Seckin Ltd | Wholesale & retail | 2023 |
| Dawson Veterinary Limited | Professional & scientific | 2012 |
| DB Technical Ltd | Professional & scientific | 2015 |
| Dbapexcommerce Ltd | Wholesale & retail | 2026 |
| DC Manufacturing Solutions Limited | Manufacturing | 2019 |
| DC Services (NE) Ltd | Information & communication | 2022 |
| Dcdm Ltd | Information & communication | 2018 |
| DCS Industrial Developments Limited | Extraterritorial | 2020 |
| DCS Industrial Limited | Transport & logistics | 2019 |
| DD Utilities NE Ltd | Construction | 2023 |
| DDF Tutoring Ltd | Education | 2023 |
| Ddsquared Ltd | Professional & scientific | 2001 |
| DE Groundworks Limited | Construction | 2019 |
| DE Jong International Limited | Professional & scientific | 2004 |
| DE Utilities Limited | Energy | 2025 |
| Dean Taylor Construction Ltd | Construction | 2017 |
| Decade Seven Ltd | Information & communication | 2023 |
| Decon Engineering Limited | Professional & scientific | 2025 |
| Decon Industries Limited | Manufacturing | 2008 |
| Decron Horse Care (UK) Limited | Manufacturing | 2023 |
| Deeba Medical Services Limited | Health & social care | 2015 |
| Deerness Fencing & Landscaping Limited | Administrative & support | 1985 |
| Deerness Gymnastics Academy Ltd | Arts & recreation | 2011 |
| Deerness Investments Limited | Administrative & support | 2021 |
| Deerness Laser Crafts Ltd | Wholesale & retail | 2019 |
| Deerness LK Ltd | Real estate | 2023 |
| Deerness PUB Company Limited | Hospitality | 2017 |
| DEG Consults Limited | Health & social care | 2015 |
| Degree 33 Ltd | Construction | 2020 |
| Delfranco Ltd | Manufacturing | 2025 |
| Demeter Group Services Ltd | Wholesale & retail | 2024 |
| Dendra Consulting Ltd | Professional & scientific | 2008 |
| Dene Beck Gardens JV Limited | Construction | 2026 |
| Denkur Ltd | Wholesale & retail | 2024 |
| Dennings Limited | Financial services | 2024 |
| Dennis Smith Ltd | Transport & logistics | 2026 |
| Dents Bakery Ltd | Manufacturing | 2015 |
| Dependabuild Ltd | Construction | 2025 |
| Derandd Investment Partners Limited Partnership | | 2004 |
| Dere Street Homes Limited | Construction | 2005 |
| Dermap Limited | Health & social care | 2021 |
| Derwent Vinyls Limited | Wholesale & retail | 2007 |
| Derwentside Property Maintenance Limited | Other services | 2020 |
| Design and Innovation Limited | Construction | 2023 |
| Design on Demand Ltd | Professional & scientific | 2009 |
| Designer Flooring Services Ltd | Construction | 2020 |
| Destro Landscapes Ltd | Administrative & support | 2023 |
| Detoxopia Ltd | Wholesale & retail | 2023 |
| DEV Bunch Ltd | Information & communication | 2022 |
| Development and Support Limited | Health & social care | 2025 |
| Devereux Energy Ltd | Construction | 2026 |
| Devlin's Enterprise Ltd | Real estate | 2022 |
| Dewhirst Holywell Enterprises Limited | Agriculture & fishing | 1998 |
| DFP Property Management Ltd | Real estate | 2020 |
| DFP Services Holdings Ltd | Financial services | 2018 |
| DFP Services Limited | Manufacturing | 2000 |
| Dftm Holding Ltd | Professional & scientific | 2017 |
| DFV Management Services Ltd | Professional & scientific | 2019 |
| DG Barbering Ltd | Other services | 2018 |
| DG Enterprises (NE) Ltd | Real estate | 2016 |
| DH Catering Limited | Hospitality | 2022 |
| DH Construction (NE) Ltd | Construction | 2019 |
| DH Woodmachines Limited | Manufacturing | 2015 |
| DH1 Design and Build Ltd | Construction | 2024 |
| DH1 Flats Ltd | Real estate | 2025 |
| DH1 Holdings Ltd | Hospitality | 2025 |
| DH1 Lettings Ltd | Real estate | 2018 |
| DH1 Propertys Ltd | Real estate | 2026 |
| DH1 Sub-Lettings Ltd | Extraterritorial | 2018 |
| DH13 Pubs Ltd | Hospitality | 2016 |
| DH1LANDSCAPES Limited | Agriculture & fishing | 2019 |
| DH2 Pubs Ltd | Hospitality | 2016 |
| DH6 Design Ltd | Professional & scientific | 2023 |
| DH7 Investments Ltd | Real estate | 2024 |
| Dharma Initiative Ltd | Wholesale & retail | 2025 |
| DHI Consulting London Ltd | Administrative & support | 2016 |
| DHL Holdings Ltd | Financial services | 2024 |
| DHM Padel Ltd | Arts & recreation | 2025 |
| DHM Supplies Ltd | Wholesale & retail | 2022 |
| DHS Educational Foundation Limited | Education | 2007 |
| Diag Test Limited | Manufacturing | 2012 |
| Dial Cabbies Limited | Transport & logistics | 2022 |
| Diamond CUT Worksurfaces Limited | Construction | 2013 |
| Diamond Intelligence Limited | Information & communication | 2026 |
| Diamond Nail Supplies Limited | Wholesale & retail | 2018 |
| Dibera Ltd | Hospitality | 2021 |
| Didi's Takeaway Ltd | Hospitality | 2025 |
| Dieselwonders Ltd | Wholesale & retail | 2025 |