| Crescent Moon Capital Limited | Real estate | 2014 |
| Crispin (Pharmacy) Limited | Health & social care | 2000 |
| Crispin Enterprises Limited | Wholesale & retail | 2018 |
| CRN Store Ltd | Wholesale & retail | 2025 |
| Cronin Glover Consultants Limited | Professional & scientific | 2025 |
| Crosby Strategic Consultancy Limited | Professional & scientific | 2023 |
| Cross Valley Court Management Company Limited | Professional & scientific | 2003 |
| Crossco (281) Limited | Real estate | 1997 |
| Crossco Limited | Administrative & support | 2004 |
| Crossing the Line Ltd | Financial services | 2008 |
| Crown Classic International Ltd | Wholesale & retail | 2024 |
| Croxdale Car & Van Rental Limited | Administrative & support | 2021 |
| Crust Like That Limited | Hospitality | 2019 |
| CSG Studios Ltd | Information & communication | 2023 |
| CSR Legal Limited | Professional & scientific | 2025 |
| CST Project Services Limited | Professional & scientific | 2023 |
| CTB Car and Commercial Ltd | Wholesale & retail | 2024 |
| Cube Online Services Limited | Administrative & support | 2021 |
| Cumbria Academy Limited | Education | 2024 |
| Cundall Medical Services Limited | Health & social care | 2013 |
| Cunningham Leisure Parks Limited | Hospitality | 2020 |
| Curran Property (NE) Limited | Real estate | 2023 |
| Custodia PUB Company Limited | Hospitality | 2023 |
| CUT N Edge Barbers (NE) Ltd | Other services | 2023 |
| Cuthbertson K9 Services Limited | Administrative & support | 2023 |
| Cutmore Commercial Repairs Ltd | Wholesale & retail | 2016 |
| Cwml Ltd | Wholesale & retail | 2026 |
| CX Holdings Ltd | Financial services | 2021 |
| CX Telecoms Ltd | Construction | 2014 |
| CX Traffic Management Ltd | Construction | 2021 |
| Cycle Away Limited | Wholesale & retail | 2020 |
| Cycleway Sport & Leisure Ltd | Wholesale & retail | 2005 |
| Cycling Platform Limited | Wholesale & retail | 2025 |
| Cygneture Research Solutions Ltd | Professional & scientific | 2024 |
| Cymro Group Holdings Ltd | Financial services | 2025 |
| Cymro Group Investments Ltd | Financial services | 2025 |
| Cymro Group Real Estate Ltd | Financial services | 2025 |
| Cymro Group Services Ltd | Financial services | 2025 |
| Cyrus Barbers Ltd | Other services | 2026 |
| D & a PUB Company Limited | Hospitality | 2022 |
| D & L Investments ( North East) Ltd | Real estate | 2013 |
| D & T Stone Masonry Limited | Construction | 2023 |
| D a Tudhope Ltd | Arts & recreation | 2014 |
| D Chester Roofing Limited | Construction | 2024 |
| D F Barratt Limited | Construction | 2003 |
| D I H Group Ltd | Health & social care | 2021 |
| D I H Oldham Limited | Health & social care | 2025 |
| D I H Property Limited | Real estate | 2021 |
| D I Harries Manchester Limited | Health & social care | 2019 |
| D Innes Ltd | Real estate | 2019 |
| D M S (a) Limited | Financial services | 2021 |
| D P M Finance LLP | | 2009 |
| D Tulip Asbestos Consulting Ltd | Professional & scientific | 2024 |
| D Wilson Scaffolding Limited | Construction | 2024 |
| D&A Health Products Ltd | Wholesale & retail | 2025 |
| D&D Construction NE Ltd | Construction | 2024 |
| D. I. Harries Limited | Health & social care | 2015 |
| D. Minnis & Sons Ltd | Construction | 2019 |
| D. Ward Plant Hire Limited | Construction | 1989 |
| D.A Services Durham Ltd | Manufacturing | 2024 |
| D.A.P. Scientific Limited | Professional & scientific | 2006 |
| D.C. Construction (NE) Ltd | Construction | 2019 |
| D.I. Harries Clyde Limited | Health & social care | 2025 |
| D.I. Harries Cramlington Limited | Health & social care | 2021 |
| D.I. Harries Darlington Limited | Health & social care | 2017 |
| D.I. Harries Estates Limited | Real estate | 2020 |
| D.I. Harries Glasburgh Limited | Health & social care | 2017 |
| D.I. Harries Greater Manchester Limited | Health & social care | 2021 |
| D.I. Harries Liverpool Limited | Health & social care | 2019 |
| D.I. Harries Livingston Limited | Health & social care | 2020 |
| D.I. Harries Middlesbrough Limited | Health & social care | 2018 |
| D.J.H. (Group) Limited | Manufacturing | 1982 |
| D.J.H. Engineering Limited | Manufacturing | 2013 |
| D33 Ltd | Construction | 2021 |
| Da-Zero Italian Ltd | Hospitality | 2024 |
| Dabner Anaesthesia Services Limited | Health & social care | 2013 |
| Dach Properties Limited | Real estate | 2023 |
| Dacoast Limited | Real estate | 2026 |
| Daemon Holdings Company Limited | Hospitality | 2021 |
| Dafi Soft Ltd | Wholesale & retail | 2023 |
| Daggs Medical Services Ltd | Health & social care | 2025 |
| Daisy Box Catering Limited | Hospitality | 2025 |
| Daisy Rose Coffee House Ltd | Hospitality | 2019 |
| DAK Business Consultancy Limited | Professional & scientific | 2007 |
| Dale and Waters Ltd | Hospitality | 2018 |
| Dale Bike Hire Limited | Extraterritorial | 2006 |
| Daley Property Investments Ltd | Real estate | 2026 |
| Dalquhandy Windfarm SPV Limited | Real estate | 2023 |
| Damper Pro Ltd | Construction | 2024 |
| DAN & YAS Ltd | Real estate | 2024 |
| Danat Properties Ltd | Real estate | 2024 |
| Danehill Holdings Ltd | Financial services | 2025 |
| Daniels Joinery and Building Limited | Construction | 2017 |
| Danu Assets Ltd | Professional & scientific | 2026 |
| Darkening Design Limited | Professional & scientific | 2021 |
| Darla Bloom Ltd | Wholesale & retail | 2024 |
| Darlington Law Limited | Wholesale & retail | 2018 |
| Darras Hall Developments Ltd | Construction | 2023 |
| Darren Edward Kemp Ltd | Extraterritorial | 2022 |
| Dartford Residential Services Limited | Real estate | 2017 |