| Cryonics UK Limited | Professional & scientific | 2001 |
| Curious Cleo Ltd | Wholesale & retail | 2014 |
| Custom Candles Limited | Manufacturing | 1975 |
| Custom Welding & Fabrication Ltd | Manufacturing | 2024 |
| D & C Lowe & Sons Ltd | Agriculture & fishing | 2019 |
| D C Booth Property Ltd | Construction | 2025 |
| D M Westley Consulting Ltd | Professional & scientific | 2023 |
| D&T Projects Ltd | Construction | 2018 |
| D.S. Mccall Butchers Ltd | Wholesale & retail | 2003 |
| Dagbasi Ltd | Hospitality | 2026 |
| Dagmar Hart Properties Limited | Real estate | 2023 |
| Daly Homes Limited | Real estate | 2023 |
| Dancing Anchor Spirits Ltd | Manufacturing | 2020 |
| Dancing for Health UK Limited | Arts & recreation | 2016 |
| Daniel Hobson Plumbing and Heating Ltd | Construction | 2016 |
| Daniel Johnson Financial Services Ltd | Professional & scientific | 2023 |
| Danson & Co Ltd | Professional & scientific | 2013 |
| Dark Wander Ltd | Information & communication | 2025 |
| Datalift Limited | Information & communication | 1997 |
| David Carter Furniture Limited | Wholesale & retail | 2015 |
| DB Business Solutions Limited | Professional & scientific | 2018 |
| DB Joinery DEV Ltd | Administrative & support | 2016 |
| DC Partitions Ltd | Construction | 2019 |
| DCE Services Ltd | Water & waste | 2024 |
| DCS Property Management Ltd | Real estate | 2018 |
| Decorated WG Ltd | Construction | 2026 |
| DEJ Welding Services Ltd | Manufacturing | 2026 |
| Delawin Sound Ltd | Wholesale & retail | 2025 |
| Deli Caterers Ltd | Hospitality | 2024 |
| Design Ability Partnership Limited | Professional & scientific | 2015 |
| Detec Software Ltd | Professional & scientific | 2015 |
| DFB 2023 Limited | Extraterritorial | 2011 |
| DHP11 Limited | Information & communication | 1999 |
| DIAMOND1962 Limited | Manufacturing | 2025 |
| Direct Computers 2008 Ltd | Information & communication | 2023 |
| Discover Tribe Ltd | Education | 2017 |
| DJV Vehicle Solutions Ltd | Wholesale & retail | 2025 |
| Dobson Property Services Limited | Real estate | 2010 |
| Dolled UP Hair Limited | Other services | 2023 |
| Double D Bakery Solutions Ltd | Hospitality | 2021 |
| Douglas Quay Group Limited | Professional & scientific | 1988 |
| Dovedale Property Investments Ltd | Real estate | 2017 |
| Dovedale Property Lettings Ltd | Real estate | 2017 |
| Dovetail Gardening Services Ltd. | Administrative & support | 2019 |
| DP Skincare Ltd | Other services | 2018 |
| DR Roberta Radcliffe-Birds Psychology Services Ltd | Health & social care | 2026 |
| Dreamstone Developments Limited | Construction | 2013 |
| Dronfield Accident Repair Centre Ltd | Wholesale & retail | 2018 |
| Dronfield Arms Limited | Hospitality | 2011 |
| Dronfield Aspire Solutions Ltd | Construction | 2024 |
| Dronfield Autocare MOT Centre Ltd | Wholesale & retail | 2013 |
| Dronfield Commercial Properties Limited | Extraterritorial | 2012 |
| Dronfield Delivery Service Limited | Extraterritorial | 2012 |
| Dronfield Electrical Services Ltd | Construction | 2017 |
| Dronfield Embroidery Company Ltd | Manufacturing | 2023 |
| Dronfield Football Club CIC | Arts & recreation | 2024 |
| Dronfield Glazing Company Ltd | Construction | 2018 |
| Dronfield Gymnastics Academy CIC | Arts & recreation | 2012 |
| Dronfield Hair Studio Limited | Other services | 2024 |
| Dronfield Heating & Welding Company Limited | | 1972 |
| Dronfield Nursery Limited | Education | 2013 |
| Dronfield Psychological Therapies Ltd | Health & social care | 2018 |
| Dronfields GOT Wood Limited | Administrative & support | 2023 |
| DS Robertson Electrical Ltd | Construction | 2024 |
| DSR Demolition Limited | Water & waste | 2001 |
| Dunbar Print Ltd | Manufacturing | 2023 |
| Dunston Properties (Chesterfield) Limited | Real estate | 1998 |
| DUO Dronfield Limited | Other services | 2018 |
| Dustaway Elite Cleaners Limited | Administrative & support | 2020 |
| DW Beers Ltd | Wholesale & retail | 2016 |
| DW Edit Ltd | Professional & scientific | 2026 |
| Dynamic Capital & Investments NO.1 Limited | Real estate | 2022 |
| E D Steel Ltd | Wholesale & retail | 2017 |
| Earth Electrical Response Limited | Manufacturing | 2011 |
| ECA Epbd Services Limited | Professional & scientific | 2004 |
| Eclectic Hearth Ltd. | Wholesale & retail | 2024 |
| Ecohome Holdings Limited | Wholesale & retail | 2023 |
| ED & Harp Design and Build Limited | Construction | 2021 |
| ED & Harp Properties Limited | Construction | 2016 |
| Eden-Brown Property Ltd | Real estate | 2025 |
| Education Academy Limited | Other services | 2011 |
| Education and Healthy Living Limited | Wholesale & retail | 2026 |
| Eggyeggeggo Ltd | Professional & scientific | 2022 |
| Eight Apart Limited | Professional & scientific | 2021 |
| Eightstyle Limited | Real estate | 2011 |
| EJB Ltd | Financial services | 2026 |
| EJT Developments Limited | Real estate | 2019 |
| Elags Ltd | Manufacturing | 2021 |
| Electronic Commerce Group Limited | Information & communication | 2005 |
| Elite Footwear Limited | Wholesale & retail | 2002 |
| Elite Performance Tuning Limited | Wholesale & retail | 2021 |
| Eliteflow+ Ltd | Wholesale & retail | 2025 |
| Elsto Limited | Real estate | 2022 |
| Emily Sleep Scoring Ltd | Professional & scientific | 2023 |
| Emmis Developments Ltd | Real estate | 2023 |
| Empowered Health and Wellness Limited | Health & social care | 2025 |
| EMQ Limited | Professional & scientific | 2017 |
| Engineering Experts Ltd | Construction | 2025 |
| Enterprise Forward Ltd | Information & communication | 2022 |
| Envisioning Advisory Ltd | Professional & scientific | 2025 |