| Bedford Rock Drill Components Limited | Manufacturing | 2003 |
| BEE Happy Toys Ltd | Wholesale & retail | 2019 |
| Beer House S6 Limited | Hospitality | 2022 |
| Bell Education Limited | Education | 2025 |
| Belmayne Independent Financial Services LLP | | 2004 |
| Bentley Hall Limited | Professional & scientific | 2016 |
| Beyond CAD Limited | Information & communication | 2020 |
| Bgwh Ltd | Wholesale & retail | 2023 |
| Billers Limited | Administrative & support | 2019 |
| Blackbird Veterinary Services Limited | Professional & scientific | 2024 |
| Blackwell's Consultancy Services Ltd | Information & communication | 2015 |
| Blade and Fade Barbers Ltd | Other services | 2024 |
| Blue Castle Investments Ltd | Hospitality | 2024 |
| Blue Castle Property Ltd | Real estate | 2024 |
| Bluepoint Fire Safety Limited | Professional & scientific | 2026 |
| BMV Cosmetic Car Repairs Limited | Wholesale & retail | 2025 |
| BOB Craig Learning & Development Limited | Education | 2013 |
| Bobl Limited | Information & communication | 2020 |
| Bowes Infrastructure Ltd | Professional & scientific | 2020 |
| Boydrory Properties Limited | Real estate | 2001 |
| Bramley Land Limited | Real estate | 2022 |
| BRG Investment Holdings Limited | Financial services | 2025 |
| Brmco (215) Limited | Real estate | 2015 |
| Brooklands Motors Limited | Wholesale & retail | 2003 |
| Broosham's Estates Ltd | Real estate | 2012 |
| Buildwright (Derbyshire) Ltd | Construction | 2014 |
| Butlers the Family Bakers Ltd | Wholesale & retail | 2003 |
| C J GAS Services Limited | Construction | 2012 |
| C J Joinery & Fitting Services Limited | Extraterritorial | 2020 |
| C Laver Plant Limited | Construction | 2009 |
| C&L Abode Ventures Ltd | Real estate | 2025 |
| C&Lpubservices Ltd | Hospitality | 2024 |
| C.C.H. Property Solutions Ltd | Real estate | 2020 |
| C.M.C. Aluminium Systems Limited | Construction | 1994 |
| Cabnet Ltd | Information & communication | 2015 |
| Camcom Systems Ltd | Information & communication | 2023 |
| Capitals Investment Ltd | Real estate | 2026 |
| Castle House Projects Limited | Construction | 2017 |
| Castlehouse Developments Limited | Construction | 2022 |
| Castleshouse Holdings Ltd | Financial services | 2025 |
| Catandra Industrial Consulting Limited | Professional & scientific | 2011 |
| Cedar Health & Wellbeing Limited | Health & social care | 2021 |
| Cedar Health and Wellbeing (Lancashire) LLP | | 2023 |
| Cedar Health and Wellbeing (North West) LLP | | 2026 |
| Cedar Propco Holdings Limited | Real estate | 2021 |
| Cedar Supported Living Limited | Health & social care | 2023 |
| Ceravella Aesthetics Ltd | Other services | 2026 |
| Certified International Systems Limited | Professional & scientific | 2001 |
| CG Locums Limited | Professional & scientific | 2008 |
| Chandlers Building Surveyors Limited | Professional & scientific | 2010 |
| Charles James Financial Planning Limited | Administrative & support | 1999 |
| Cheese Taverns Ltd. | Hospitality | 2019 |
| Chesterfield Road Management Company Limited | Households | 1990 |
| Chesterfield Taxi Hire Limited | Transport & logistics | 2018 |
| Chesterfield Taxi Supplies Limited | Transport & logistics | 2013 |
| CHI Chi's Fashion Ltd | Wholesale & retail | 2025 |
| China Chef Dronfield Limited | Hospitality | 2026 |
| Chiverton & Co Limited | Real estate | 1990 |
| Chlorination & Chemical Cleaning Services Limited | Administrative & support | 2004 |
| Chromex Scientific Limited | Wholesale & retail | 2007 |
| Cinar Grill Ltd | Hospitality | 2021 |
| Circle Eight Limited | Real estate | 2019 |
| CJ Property Rentals Ltd | Real estate | 2020 |
| Claire Knox Consulting Ltd | Professional & scientific | 2023 |
| Clan Engineering Ltd | Professional & scientific | 2004 |
| Clarity Consultancy Limited | Financial services | 2016 |
| Clarkhouse Limited | Real estate | 2012 |
| Classic Windows (Dronfield) Limited | Wholesale & retail | 2010 |
| Clearance Pallet Outlet Limited | Wholesale & retail | 2025 |
| Clearance Stock Supplies Limited | Wholesale & retail | 2016 |
| Clifton Court Facility Management Limited | Households | 2021 |
| Climate Data Intelligence Ltd | Information & communication | 2020 |
| Climax Cafe Limited | Hospitality | 2018 |
| Clin-Assist Limited | Other services | 2016 |
| Cloud Socials Limited | Professional & scientific | 2022 |
| Club Reformer Ltd | Arts & recreation | 2024 |
| CM Services Construction Ltd | Construction | 2025 |
| Coach and Horses Dronfield Limited | Hospitality | 2025 |
| Coates Data Services Ltd | Information & communication | 2019 |
| Coba Services Limited | Real estate | 2021 |
| Coffee Central Dronfield Ltd | Hospitality | 2024 |
| Commercial Cleaning Machines Ltd | Wholesale & retail | 2025 |
| Compassionate Voices CIC | Health & social care | 2019 |
| Connelly & Connelly Limited | Wholesale & retail | 2016 |
| Conrose Consulting Ltd | Professional & scientific | 2025 |
| Constant-Smith Medical Ltd | Wholesale & retail | 2025 |
| Cooper Renovations Limited | Construction | 2023 |
| Core Climbing Ltd | Manufacturing | 2008 |
| Core Layer Limited | Extraterritorial | 2025 |
| Cosy Toes Cottages Ltd | Hospitality | 2018 |
| COX & Clayton Communications Limited | Information & communication | 2008 |
| Cprox Limited | Manufacturing | 2007 |
| CR8TIVE Kitchen Co Ltd | Manufacturing | 2020 |
| Crampton & Moore Holdings Limited | Professional & scientific | 2004 |
| Crawshaw Brown Property Holdings Ltd | Real estate | 2022 |
| Creative Frontiers Limited | Arts & recreation | 2009 |
| Creative Health Monitoring Limited | Health & social care | 2019 |
| Creatoma Ltd | Information & communication | 2025 |
| Crispfine Property Renovations Ltd | Construction | 2017 |
| Crookes Confectionery Limited | Wholesale & retail | 2001 |