| Sharma’S Kiddicare Ltd | Health & social care | 2018 |
| Sharon Wright Consulting Limited | Professional & scientific | 2026 |
| Sharpway Services Ltd | Construction | 2025 |
| Shaw Asset Holdings Ltd | Real estate | 2017 |
| Shelbyit Limited | Information & communication | 2015 |
| Shepley Meadow Ltd | Households | 2019 |
| Sheryl Browne Author Ltd | Arts & recreation | 2019 |
| Shire Car Sales (Stourbridge) Ltd | Wholesale & retail | 2018 |
| Shire Car Sales (Worcestershire) Ltd | Wholesale & retail | 2015 |
| Shona Projects Limited | Administrative & support | 2021 |
| Showgirl Entertainments Limited | Arts & recreation | 2023 |
| Shroppie Flyboat Company Limited | Real estate | 1978 |
| Shropshire VET Limited | Professional & scientific | 2023 |
| SI Investment Properties Limited | Real estate | 2023 |
| Sienna X Limited | Extraterritorial | 2009 |
| Signed Ltd | Manufacturing | 2021 |
| Silhouette Property Ltd | Real estate | 2020 |
| Silver Hill Fish Bar Limited | Hospitality | 2020 |
| Silvik Courier Ltd | Transport & logistics | 2016 |
| Simon Bishop Property Services Limited | Professional & scientific | 2010 |
| Simon Donnellon Studio Ltd | Arts & recreation | 2026 |
| Simon Hale Music Limited | Arts & recreation | 2003 |
| Simon Smart Medical Limited | Health & social care | 2014 |
| Simpic Limited | Administrative & support | 2019 |
| Simply Upholstery Ltd | Wholesale & retail | 2022 |
| Sino Manufacturing Solutions Limited | Administrative & support | 2006 |
| Sisi & SEB Art Limited | Professional & scientific | 2019 |
| Site Fabrication and Welding Services Limited | Manufacturing | 2018 |
| Situated Architects Ltd | Professional & scientific | 2017 |
| SIX Crafty Dogs Limited | Hospitality | 2022 |
| SIX Point Properties Limited | Administrative & support | 2008 |
| SJ Dyson Engineering Ltd | Professional & scientific | 2025 |
| SJ Whiting Ltd | Transport & logistics | 2025 |
| Sjvk Investments Limited | Administrative & support | 2017 |
| SJW Psychological Services Ltd | Health & social care | 2017 |
| Skapi Limited | Arts & recreation | 2023 |
| Skdp UK Limited | Hospitality | 2021 |
| Skirtings R US Limited | Manufacturing | 2012 |
| Sky Sprint Courier Ltd | Transport & logistics | 2025 |
| Skyfall INV Limited | Arts & recreation | 2023 |
| Skypark (U.K.) Limited | Construction | 1990 |
| Skypark Flight Centre Limited | Construction | 2011 |
| Skypark Holding Limited | Financial services | 2024 |
| Skytrade Associates Limited | Administrative & support | 2016 |
| Slate and Reed Property Ltd | Real estate | 2025 |
| Slot & Go Limited | Manufacturing | 2021 |
| SLP Installations Limited | Manufacturing | 2022 |
| Smakbang Limited | Wholesale & retail | 2008 |
| Smart Accountancy Solutions Limited | Professional & scientific | 2007 |
| Smart Anaesthesia Limited | Health & social care | 2014 |
| Smart Eco Electrical Ltd | Construction | 2024 |
| Smart Electricity Meters Ltd | Financial services | 2011 |
| Smart Ideas Holdings Limited | Wholesale & retail | 2020 |
| Smart Ideas Limited | Wholesale & retail | 1988 |
| Smart Sedation Limited | Health & social care | 2014 |
| Smarter Property Company Limited | Real estate | 2015 |
| Smartordering.Com Limited | Information & communication | 2012 |
| Smartunknowns.Com Limited | Information & communication | 2015 |
| Smash Collective Limited | Construction | 2026 |
| Smiths Cycles and Toys (Kidderminster) Limited | Real estate | 1963 |
| SN Business Solutions Limited | Professional & scientific | 2018 |
| SN Financial Services Limited | Financial services | 2003 |
| Snowcap Cyber Limited | Information & communication | 2022 |
| Snowfox Consulting Limited | Professional & scientific | 2014 |
| SO22 Ltd | Construction | 2021 |
| Sobbs Salt and Brine Heritage C.I.C. | Health & social care | 2015 |
| Sodium Cyber Limited | Information & communication | 2022 |
| Sofasac Ltd | Administrative & support | 2023 |
| Soflo Limited | Administrative & support | 2020 |
| Software Raven Limited | Information & communication | 2023 |
| Solaris Technology Ltd | Administrative & support | 2016 |
| Solihull and Warwickshire ENT Ltd | Health & social care | 2018 |
| Solihull Kiddicare Ltd | Health & social care | 2022 |
| Solstice (SW) Ltd | Construction | 2012 |
| Sooni Ltd | Manufacturing | 2025 |
| Sorcery Records Limited | Information & communication | 2011 |
| Sorma (UK) Limited | Extraterritorial | 2013 |
| Sound Effects Limited | Administrative & support | 2018 |
| Southall and Rush Ltd | Construction | 2017 |
| Southcot Holdings Limited | Administrative & support | 2015 |
| SP Creative Solutions Ltd | Professional & scientific | 2016 |
| Spa & Leisure Properties Ltd | Hospitality | 2022 |
| Spa Car Spares Limited | Other services | 2019 |
| Spa DEC Lets Limited | Real estate | 2018 |
| Spa Decorators Limited | Construction | 2006 |
| Spa Fire Doors Ltd | Construction | 2022 |
| Spa Furnishings Ltd | Wholesale & retail | 2012 |
| Spa GAS Building Services Limited | Construction | 2018 |
| Spa GAS Holdings Limited | Professional & scientific | 2017 |
| Spa GAS Limited | Construction | 1998 |
| Spa Guttering Limited | Construction | 2007 |
| Spa Stairlifts Ltd | Administrative & support | 2017 |
| Spa Track Medical Limited | Manufacturing | 2014 |
| Space Leasing Limited | Other services | 2025 |
| Spark & Zoom Productions Limited | Manufacturing | 1994 |
| Sparkfire Limited | Wholesale & retail | 2003 |
| Sparkle Cleaning Co Limited | Water & waste | 2009 |
| SPB GP Services Ltd | Health & social care | 2025 |
| Specialised Electrical Limited | Administrative & support | 2016 |
| Specialist ENT Care Limited | Health & social care | 2014 |