| S a Evers & Co. Ltd | Construction | 2019 |
| S Arooj Services Ltd | Wholesale & retail | 2021 |
| S C Services (GB) Ltd | Construction | 2014 |
| S J Capital Limited | Real estate | 2020 |
| S K M Construction Limited | Construction | 2013 |
| S T P Contracts Ltd | Construction | 2021 |
| S&F Real Estate Group Ltd | Financial services | 2025 |
| S&J Medical Limited | Health & social care | 2023 |
| S.S.J. Medics LLP | | 2013 |
| S4 Developments Ltd | Real estate | 2019 |
| SA21 Group Limited | Other services | 2021 |
| Sabre Furniture Limited | Manufacturing | 2020 |
| Safe Driving Academy Limited | Education | 2006 |
| Saint George's PUB Company Ltd | Professional & scientific | 2012 |
| Sala Technology Limited | Information & communication | 2009 |
| Salad Menus Ltd | Hospitality | 2026 |
| Saleway Ltd | Wholesale & retail | 2016 |
| Salinae Services Limited | Professional & scientific | 2017 |
| Sally Hall Financial Services Limited | Financial services | 2019 |
| Salt Talent Solutions Ltd | Administrative & support | 2025 |
| Saltway Health&Safety Services Ltd | Professional & scientific | 2022 |
| Saltway Holdings Limited | Administrative & support | 2020 |
| Saltwell Group Ltd | Construction | 2022 |
| Saltwood Contracting Ltd | Real estate | 2025 |
| Salwarpe Business Solutions Limited | Information & communication | 1994 |
| Salwarpe Consulting Limited | Financial services | 2023 |
| Sanders Fitness Limited | Administrative & support | 2012 |
| Sanders Training Limited | Other services | 2015 |
| Sandhu Saab Enterprises Ltd | Hospitality | 2013 |
| Sandie Marie Ltd | Wholesale & retail | 2025 |
| Sandstrom Group Limited | Financial services | 2025 |
| Sandstrom Properties Ltd | Real estate | 2026 |
| Sandstrom Property Ltd | Real estate | 2026 |
| Sandstrom Surveyors Limited | Professional & scientific | 2025 |
| Sandy CNC Ltd | Manufacturing | 2026 |
| Sandys Arms Limited | Hospitality | 2010 |
| Sarah & Magic Ltd | Transport & logistics | 2021 |
| Sarah Hill Reflexology Limited | Other services | 2021 |
| Sarah Lettl Sanderson Ltd | Information & communication | 2024 |
| Sarah Page Limited | Arts & recreation | 2021 |
| Saram Hotels Droitwich Ltd | Hospitality | 2023 |
| Saram Hotels Holdings Ltd | Hospitality | 2019 |
| Saram Hotels Kingswinford Ltd | Hospitality | 2020 |
| Saram Hotels Lichfield Limited | Hospitality | 2025 |
| Saram Hotels Ltd | Hospitality | 2008 |
| Saram Hotels Ludlow Ltd | Financial services | 2024 |
| Saram Hotels Scarborough Ltd | Hospitality | 2019 |
| Saram Hotels Skegness Limited | Hospitality | 2020 |
| Saram Hotels Telford Limited | Hospitality | 2025 |
| Saram Hotels Warrington Ltd | Hospitality | 2020 |
| Sasa Oxford Ltd | Administrative & support | 2014 |
| Satbk Newco Limited | Financial services | 2026 |
| Saxon Personnel Ltd | Other services | 2018 |
| SB Process Consultancy Limited | Professional & scientific | 2025 |
| SC Tempco Limited | Financial services | 2023 |
| SCA Business Services Limited | Professional & scientific | 2018 |
| Scalia Holdings Limited | Financial services | 2026 |
| Scarborough House Properties Limited | Real estate | 2012 |
| Schadtz Limited | Administrative & support | 2017 |
| Schoenmaker Limited | Arts & recreation | 2023 |
| School House Consulting Ltd | Other services | 2023 |
| Scorpion Geoscience Limited | Professional & scientific | 2020 |
| Scott-Jameson Property Ltd | Real estate | 2021 |
| Scottbrannan Limited | Administrative & support | 2013 |
| Scubaregs LLP | | 2021 |
| SD Machine Tools Limited | Administrative & support | 2023 |
| SDF Site Services Ltd | Administrative & support | 2016 |
| SDH Vascular Ltd | Administrative & support | 2015 |
| SE Construct Ltd | Construction | 2026 |
| Seathade Ltd | Hospitality | 2021 |
| SEB Brooks Limited | Real estate | 2025 |
| Secure Options Limited | Administrative & support | 2020 |
| Secure Vulnerability Scanning Services Limited | Administrative & support | 2018 |
| Sedghi Holdings Limited | Professional & scientific | 2014 |
| Sekatech Ltd | Professional & scientific | 2000 |
| Select Contracting Services Limited | Information & communication | 2016 |
| Sellingastairlift Limited | Administrative & support | 2025 |
| Selseyuk Limited | Wholesale & retail | 2015 |
| Sencon (UK) Limited | Wholesale & retail | 1987 |
| Sencon Europe Limited | Manufacturing | 1992 |
| Senectus Medical Ltd | Health & social care | 2019 |
| Sensemade Limited | Administrative & support | 2012 |
| Sentio Holdings Limited | Financial services | 2022 |
| Sentio Insurance Brokers Limited | Financial services | 2014 |
| Sentio Networks Limited | Financial services | 2022 |
| Sentio Salons Limited | Financial services | 2023 |
| Seoul Bird Canary Wharf Ltd | Wholesale & retail | 2020 |
| Seriphos Limited | Administrative & support | 2013 |
| Service Instinct Ltd | Wholesale & retail | 2023 |
| Seven Twenty Bespoke Ltd | Administrative & support | 2021 |
| Severn Court RTM Company Limited | Households | 2019 |
| Severnside Veterinary Services Limited | Professional & scientific | 2009 |
| Sevo Team Limited | Construction | 2020 |
| SFS Protect Limited | Administrative & support | 2017 |
| SG Medical Ltd | Health & social care | 2019 |
| Sgauk Limited | Professional & scientific | 2021 |
| Shaanti 11 Ltd | Arts & recreation | 2012 |
| Shahzad Sadiq Limited | Administrative & support | 2011 |
| Shamztrium Ltd | Hospitality | 2021 |
| Shapers’ Technical Solutions UK Ltd | Manufacturing | 1969 |