| DMS Laminated Floors & Walls Limited | Construction | 1997 |
| Dmss Limited | Professional & scientific | 2008 |
| Dogs and Families Limited | Wholesale & retail | 2011 |
| Dokeo Limited | Professional & scientific | 2010 |
| Dokeo Properties Limited | Administrative & support | 2022 |
| Dollys Autos Limited | Wholesale & retail | 2015 |
| DON Catchment Rivers Trust | Agriculture & fishing | 2008 |
| Doncaster Power (10MW) Limited | Energy | 2018 |
| Doncaster Power 16MW Limited | Energy | 2023 |
| Doncaster Power Projects Limited | Energy | 2022 |
| DR Paul Saunders Ltd | Health & social care | 2010 |
| DR Susan Mayou Practice Ltd | Health & social care | 2014 |
| Drawstate Limited | Real estate | 1989 |
| Drexler Ltd | Financial services | 2013 |
| Driffield Agricultural Society | Administrative & support | 1996 |
| Driffield and District Skate and BMX Park Limited | Arts & recreation | 2003 |
| Driffield Car Repairs Ltd | Administrative & support | 2018 |
| Driffield Electrical Supplies Limited | Wholesale & retail | 2007 |
| Driffield Handyman Services Limited | Other services | 2024 |
| Driffield Health Hub Limited | Arts & recreation | 2016 |
| Driffield Hub Cafe Ltd | Hospitality | 2017 |
| Driffield Locum Services Ltd | Health & social care | 2014 |
| Driffield Mobility Limited | Wholesale & retail | 2007 |
| Driffield Pizzeria Ltd | Hospitality | 2025 |
| Driffield Plant Hire Limited | Administrative & support | 2004 |
| Driffield Private Ltd | Extraterritorial | 2019 |
| Driffield Rugby Supporters Limited | Arts & recreation | 2026 |
| Driffield Rugby Union Football Club (1994) Limited | Professional & scientific | 1994 |
| Driffield Self Store Limited | Other services | 2024 |
| Driffield Showground Events Limited | Arts & recreation | 2012 |
| Driffield Tool Hire and Sales Ltd | Administrative & support | 2023 |
| Driffield Travel Limited | Administrative & support | 1994 |
| Drifford Group Limited | Professional & scientific | 2012 |
| Dringhoe Holiday Cottages Ltd | Hospitality | 2017 |
| Drinkwater Broad Limited | Professional & scientific | 2021 |
| DSM and Sons Plumbing Limited | Construction | 2024 |
| Dswh Limited | Health & social care | 2024 |
| DTP Tractors Ltd | Wholesale & retail | 2013 |
| Dunston (Ship Repairers) Limited | Energy | 1993 |
| Dusty Roads Europe Ltd | Agriculture & fishing | 2026 |
| E R GIN & Kitchen Ltd | Hospitality | 2018 |
| E R Megginson and Sons Limited | Real estate | 2000 |
| E Reed & SON Limited | Agriculture & fishing | 2025 |
| E, M & J Services Limited | Agriculture & fishing | 2012 |
| E.Falkingham and Sons Limited | Agriculture & fishing | 1955 |
| E.L. Robinson (Lincs) Limited | Agriculture & fishing | 1972 |
| E.R.T. Holdings Limited | Financial services | 2018 |
| East Coast Construction (N.E.) Ltd | Construction | 2004 |
| East Coast Operators Ltd | Construction | 2025 |
| East Riding Crop Consultancy Limited | Agriculture & fishing | 1974 |
| East Riding Farm Services Limited | Agriculture & fishing | 1997 |
| East Riding Power Tools Ltd | Administrative & support | 1991 |
| East Yorkshire Arts and Wellbeing CIC | Arts & recreation | 2024 |
| East Yorkshire Construction Ltd | Construction | 2018 |
| East Yorkshire Cottages Limited | Hospitality | 2018 |
| East Yorkshire Developments Limited | Real estate | 2003 |
| East Yorkshire Drones Ltd | Other services | 2011 |
| East Yorkshire Farms Limited | Agriculture & fishing | 2011 |
| East Yorkshire Gates Ltd | Manufacturing | 2021 |
| East Yorkshire Hospitality Developments Ltd | Construction | 2025 |
| East Yorkshire Motorworx Ltd | Wholesale & retail | 2026 |
| East Yorkshire Plumbing and GAS Services Limited | Construction | 2021 |
| Eastburn Farms Limited | Agriculture & fishing | 1960 |
| Ebberston Lettings Ltd | Hospitality | 2023 |
| Eccne Holdings Limited | Financial services | 2024 |
| Eddsfield Limited | Transport & logistics | 2010 |
| Ee-Why Service Station Limited | Wholesale & retail | 2020 |
| EGG Creative Interiors Ltd | Construction | 2015 |
| Eggsell Limited | Wholesale & retail | 2003 |
| Egton Enterprises Limited | Agriculture & fishing | 1998 |
| EJ Properties (Yorkshire) Ltd | Real estate | 2022 |
| EKO SB Investments Limited | Construction | 2019 |
| Eldwick Limited | Construction | 1989 |
| Electrical LAB Services Ltd | Manufacturing | 2019 |
| Eling Limited | Wholesale & retail | 1959 |
| Elite Finance Group Limited | Professional & scientific | 2007 |
| Elite Gardening & Landscaping Ltd | Administrative & support | 2024 |
| Eliteco 001 Limited | Wholesale & retail | 2022 |
| Eliteholdco (001) Limited | Financial services | 2024 |
| Ellerington Engineering Ltd | Construction | 2010 |
| Ellias James Holdings Limited | Professional & scientific | 2024 |
| Ellias James Limited | Real estate | 2016 |
| Elliott Eggs Limited | Agriculture & fishing | 2004 |
| Elliott Eggs Services Limited | Administrative & support | 2024 |
| Ellis Portfolios Limited | Construction | 2020 |
| Elmfield Civil Engineering Ltd | Construction | 2023 |
| Elmfield Lettings Limited | Real estate | 2025 |
| Elmstead Medical Ltd | Health & social care | 2018 |
| Elmswell Heritage Limited | Arts & recreation | 2004 |
| Elmway Education Ltd | Education | 2023 |
| ELR Property Ltd | Real estate | 2023 |
| Elstons Butchers Limited | Wholesale & retail | 2021 |
| Emailmovers Limited | Professional & scientific | 2004 |
| Emma House Limited | Other services | 2009 |
| Emmotland Leisure Limited | Agriculture & fishing | 2011 |
| Engage Audio Visual Ltd | Administrative & support | 2022 |
| Engage the Culture CIC | Education | 2026 |
| Enhanced Care Group Ltd | Health & social care | 2026 |
| Enterprise Properties (Routh) Limited | Real estate | 2000 |
| Enuma Consulting Limited | Professional & scientific | 2020 |