| South Yorkshire Medical Ltd | Health & social care | 2024 |
| South Yorkshire Metal Recycling Ltd | Administrative & support | 2021 |
| South Yorkshire Mobile Tyres Ltd | Wholesale & retail | 2025 |
| South Yorkshire Motors Ltd | Wholesale & retail | 2021 |
| South Yorkshire Mowers Ltd | Manufacturing | 2009 |
| South Yorkshire NDT Services Limited | Professional & scientific | 2012 |
| South Yorkshire Pallets Ltd | Transport & logistics | 2025 |
| South Yorkshire Property and Investments Limited | Real estate | 2016 |
| South Yorkshire Property Holdings Limited | Real estate | 2025 |
| South Yorkshire Refurbishments Limited | Construction | 2011 |
| South Yorkshire Reinforcement Ltd | Construction | 2012 |
| South Yorkshire Scaffolding Ltd | Construction | 2025 |
| South Yorkshire Storage Ltd | Other services | 2017 |
| South Yorkshire Supplements Ltd | Wholesale & retail | 2025 |
| South Yorkshire Surveyors Limited | Professional & scientific | 2018 |
| South Yorkshire Tree Services Ltd | Agriculture & fishing | 2021 |
| South Yorkshire Tyre Centre Limited | Wholesale & retail | 1992 |
| Southborough Holdings UK Limited | Financial services | 2021 |
| Southend Close Management Company Limited | Households | 2023 |
| Southview Developments Ltd | Construction | 2013 |
| Southwell-Kelly Recruitment Services Limited | Administrative & support | 2022 |
| Sovereign Financial Partners Ltd | Extraterritorial | 2020 |
| Sovereign Money Matters Group Limited | Financial services | 2023 |
| Sowgate Property Ltd | Real estate | 2025 |
| SOY Recovery Ltd | Wholesale & retail | 2026 |
| Soydas Properties Ltd | Real estate | 2020 |
| Soyo Studios Ltd | Information & communication | 2026 |
| SP Air Conditioning and Renewables Ltd | Construction | 2024 |
| SP Flooring Services Limited | Construction | 2024 |
| SP Foods Ltd | Wholesale & retail | 2022 |
| SP Transport Solutions Ltd | Transport & logistics | 2024 |
| SP2010 Ltd | Professional & scientific | 2010 |
| Space Hardware Ltd | Professional & scientific | 2015 |
| Space Lettings & Sales Limited | Real estate | 2005 |
| Spaceground Property Management Limited | Real estate | 1990 |
| Spaghetti Western Film Productions Ltd | Professional & scientific | 2021 |
| Spancat Transport Limited | Transport & logistics | 2011 |
| Spandrel Homes Ltd | Construction | 2012 |
| Spar Sprotbrough Ltd | Wholesale & retail | 2010 |
| Spare Parts Zone Ltd | Wholesale & retail | 2025 |
| Sparebolt Limited | Information & communication | 2025 |
| Sparenet Limited | Real estate | 2004 |
| Sparkle and Glow Cleaning Limited | Administrative & support | 2024 |
| Sparkmotion Agency Ltd | Information & communication | 2025 |
| Sparks Cleaning Home Services Ltd | Administrative & support | 2026 |
| Sparrow and Grass Ltd | Professional & scientific | 2023 |
| SPB Automotive Ltd | Wholesale & retail | 2020 |
| SPB Holdings Ltd | Other services | 2025 |
| SPC Personal Care Limited | Health & social care | 2026 |
| Speakeasy Enterprises Limited | Other services | 2017 |
| Speakman TM Ltd | Public administration | 2022 |
| Speakoutloud Ltd | Professional & scientific | 2016 |
| Spear Telecomms Ltd | Information & communication | 2014 |
| Spec-Uk Ltd | Professional & scientific | 2020 |
| Special Force Unlimited Ltd | Arts & recreation | 2022 |
| Special Tech Trader Ltd | Wholesale & retail | 2024 |
| Special Touch Crafts Ltd | Extraterritorial | 2011 |
| Specialised Harvesting Services Limited | Manufacturing | 1979 |
| Specialised Labour Services Ltd | Construction | 2021 |
| Specialist Automotive Products Ltd | Administrative & support | 2011 |
| Specialist Engineering Services Limited | Transport & logistics | 1997 |
| Specialist Glass Projects Limited | Construction | 2020 |
| Specialist Project Logistics Ltd | Transport & logistics | 2021 |
| Speck Properties Limited | Households | 2024 |
| Spectra Signs Ltd | Manufacturing | 2022 |
| Spectrum Comms Ltd | Construction | 2024 |
| Spectrum Psychology Ltd | Health & social care | 2026 |
| Speed on Services Ltd | Transport & logistics | 2023 |
| Speed Transport 2018 Limited | Transport & logistics | 2018 |
| Speed Web Hosting Services Ltd | Other services | 2009 |
| Speedeck TR. Ltd | Transport & logistics | 2026 |
| Speedhealth Consults Ltd | Health & social care | 2026 |
| Speeditear Rule Products Ltd | Manufacturing | 2014 |
| Speedy Commercials Ltd | Wholesale & retail | 2012 |
| Speedy Properties (Yorkshire) Ltd | Real estate | 2024 |
| Speedy Way Ltd | Transport & logistics | 2024 |
| Speedyweb and Domain Services Ltd | Other services | 2009 |
| Spencer & Sons Surfacing Ltd | Construction | 2018 |
| Spencer Fencing Ltd | Manufacturing | 2021 |
| Spencer Traffic Management Ltd | Public administration | 2016 |
| Spencing Around Ltd | Construction | 2023 |
| Spenser House Management Company Limited | Households | 1990 |
| SPH Fisheries Ltd | Agriculture & fishing | 2020 |
| SPH Property Ltd. | Real estate | 2019 |
| Spice Bar Limited | Hospitality | 2019 |
| Spice HUT DN8 Ltd | Hospitality | 2024 |
| Spices Doncaster Ltd | Hospitality | 2025 |
| Spices Donny Ltd | Hospitality | 2025 |
| Spick & Span Doncaster Ltd | Administrative & support | 2025 |
| Spick&Span Group Ltd | Construction | 2025 |
| Spick&Span Industrial Services Ltd | Administrative & support | 2025 |
| Spick&Span Worksop Ltd | Administrative & support | 2025 |
| Spinal Care Management Ltd | Health & social care | 2022 |
| Spinal Case Management Ltd | Health & social care | 2021 |
| Spire Solutions Group Ltd. | Information & communication | 2023 |
| Spire Solutions Nederland Ltd | Information & communication | 2023 |
| Spitfire Funding Limited | Financial services | 2015 |
| Spittlehouse Properties Ltd | Real estate | 2025 |
| SPJ Entities Ltd | Financial services | 2023 |
| SPJ Marketing Ltd | Professional & scientific | 2017 |