| Sofbre Ltd | Transport & logistics | 2025 |
| Sofia's Bakery Ltd | Manufacturing | 2023 |
| Sofiab Ltd | Transport & logistics | 2018 |
| Soft Media Ltd | Information & communication | 2025 |
| Softplay Ltd | Other services | 2025 |
| Soggy Tails Ltd | Wholesale & retail | 2025 |
| Sogucak Pizza Ltd | Hospitality | 2025 |
| Sohail Hashmi Ltd | Information & communication | 2024 |
| Soil Nailing Contractors UK Limited | Extraterritorial | 2014 |
| Sojourn Doncaster CIC | Health & social care | 2022 |
| Sokolowski Solutions Ltd | Administrative & support | 2025 |
| SOL Hosting Ltd | Information & communication | 2025 |
| Solajax Ltd | Administrative & support | 2022 |
| Solan and Hickey Developments Ltd | Real estate | 2021 |
| Solar 365 Ltd | Construction | 2022 |
| Solar Advice Europe Ltd | Information & communication | 2025 |
| Solar Heat Renewables Ltd | Administrative & support | 2025 |
| Solar Tronic Limited | Other services | 2022 |
| Solaro Estate Ltd | Real estate | 2026 |
| Solaro Housing Ltd | Real estate | 2026 |
| Solaro Letting Ltd | Real estate | 2026 |
| Solaro Properties Ltd | Real estate | 2025 |
| Solartex UK Limited | Construction | 2011 |
| Solarys Ltd | Financial services | 2025 |
| Solcap Bioenergy Limited | Professional & scientific | 2011 |
| Sole Mates Studio Limited | Wholesale & retail | 2025 |
| Solectricity Ltd | Other services | 2022 |
| Solendrick Ltd | Agriculture & fishing | 2020 |
| Solid Rock Services Limited | Health & social care | 2009 |
| Solid Surface Pro Ltd | Construction | 2015 |
| Solidspan Builders Ltd | Extraterritorial | 2026 |
| Solliset Properties Limited | Construction | 1993 |
| Solo Media Holding Limited | Financial services | 2024 |
| Solstice & Vale Ltd | Extraterritorial | 2025 |
| Solutions 4 Plastic Limited | Professional & scientific | 2007 |
| Solutions Doncaster Limited | Real estate | 2011 |
| Solvanta Grid Ltd | Extraterritorial | 2026 |
| Solvaryn Group Ltd | Extraterritorial | 2026 |
| Solve Consultants Limited | Administrative & support | 2015 |
| Solvexa Innovations Ltd | Extraterritorial | 2026 |
| Solvexia Holdings Ltd | Extraterritorial | 2026 |
| Solxone Ltd | Professional & scientific | 2018 |
| Soma HR Ltd | Administrative & support | 2016 |
| Something Brew Inn Limited | Hospitality | 2019 |
| SON Bahar Halal Meat Ltd | Wholesale & retail | 2026 |
| Sonalex Trans Limited | Transport & logistics | 2022 |
| Sonic Sister Limited | Professional & scientific | 2025 |
| Sonko Electricals Ltd | Manufacturing | 2024 |
| Sonni Thai Massage Limited | Other services | 2026 |
| Sonographer Claire Ltd | Health & social care | 2026 |
| Sons of Electricity Limited | Construction | 2020 |
| Sonu Sonu Ltd | Wholesale & retail | 2024 |
| Sophia Drive Limited | Transport & logistics | 2016 |
| Sophia’S Final Touch Ltd | Administrative & support | 2022 |
| Sophie Hilton Consultancy Ltd | Arts & recreation | 2024 |
| Sophie's Courier Ltd | Transport & logistics | 2021 |
| Sophtia TM Ltd | Construction | 2025 |
| SOR Serv Ltd | Construction | 2025 |
| Soran Plus 2 Ltd | Wholesale & retail | 2025 |
| Sorb EOT Trustees Limited | Administrative & support | 2025 |
| Sorea Ltd | Transport & logistics | 2020 |
| Sorelle Beauty Ltd | Other services | 2016 |
| Sorin Fita Ltd | Transport & logistics | 2016 |
| Sorin&Selina Transport Ltd | Transport & logistics | 2024 |
| Sory and Reby Ltd | Transport & logistics | 2023 |
| SOS Plumbing & Heating Solutions Ltd | Construction | 2018 |
| Sosvan Ltd. | Information & communication | 2014 |
| Soul Boutique Auckley Limited | Wholesale & retail | 2025 |
| Soul Connection Highway Ltd | Administrative & support | 2024 |
| Soul Sisters Holistic Wellness CIC | Health & social care | 2026 |
| Soular Ltd | Administrative & support | 2008 |
| Soulofagri Ltd | Agriculture & fishing | 2024 |
| Sound Mind Tiney Home Ltd | Health & social care | 2025 |
| Sound Museum Limited | Wholesale & retail | 2023 |
| Sounds of the Soul Limited | Other services | 2020 |
| Souq Souq Limited | Wholesale & retail | 2011 |
| Source 247 Processing Ltd | Administrative & support | 2024 |
| Source Business Ltd | Wholesale & retail | 2019 |
| Source Consultancy and Auditing Services Limited | Professional & scientific | 2014 |
| Sourced Limited | Professional & scientific | 2002 |
| Sourceflow Ltd. | Information & communication | 2021 |
| South Cave Car & Van Hire Ltd | Administrative & support | 2019 |
| South Electrical Limited | Construction | 2003 |
| South Manchester Onco-Anaesthetic LLP | | 2011 |
| South Parade Property Management Limited | Real estate | 2004 |
| South View Lodge Holiday Lets Ltd | Administrative & support | 2023 |
| South View Lodge Investments Ltd | Real estate | 2022 |
| South View Lodge Maintenance Ltd | Hospitality | 2025 |
| South View Lodge Sales Ltd | Wholesale & retail | 2023 |
| South Yorkshire Aircraft Museum | Arts & recreation | 2012 |
| South Yorkshire Building Services Ltd | Construction | 2025 |
| South Yorkshire Caravans Ltd | Wholesale & retail | 2020 |
| South Yorkshire Damp Proof Specialists Ltd | Construction | 2015 |
| South Yorkshire Direct Supply Ltd | Administrative & support | 2021 |
| South Yorkshire Doors Ltd | Construction | 2024 |
| South Yorkshire French Polishers Ltd | Construction | 2022 |
| South Yorkshire Heat Pumps Ltd | Extraterritorial | 2021 |
| South Yorkshire Heating Solutions Ltd | Construction | 2025 |
| South Yorkshire Institute of Technology | Education | 2023 |
| South Yorkshire Joint Railway Ltd | Transport & logistics | 2024 |