| Shelby Transport Ltd | Transport & logistics | 2022 |
| Shellmark Dwellings Ltd | Real estate | 2026 |
| Shelton Miller Limited | Real estate | 2017 |
| Shem Star Ltd | Wholesale & retail | 2020 |
| Shen Capital Ltd. | Administrative & support | 2023 |
| Sheq Experts Limited | Professional & scientific | 2022 |
| Sheqmate Ltd | Professional & scientific | 2025 |
| Sheraton Kitchens Limited | Professional & scientific | 1996 |
| Sherburn Holdings Limited | Financial services | 2023 |
| Sherburn Motor Spares Limited | Wholesale & retail | 2012 |
| Sherlock Accounts LLP | | 2020 |
| Sherratt Decorators Limited | Construction | 2019 |
| Sherwin Gardens (Bramcote) Management Company Limited | Real estate | 2024 |
| Sherwood Grange (Bilsthorpe) Management Limited | Real estate | 2022 |
| Sherzadshyar Ltd | Wholesale & retail | 2019 |
| Shesha Veda Holding Limited | Financial services | 2025 |
| Shewoolf Ltd | Professional & scientific | 2025 |
| Shexa Holdings Ltd | Real estate | 2019 |
| Shidashi-Ya Ltd | Administrative & support | 2019 |
| Shield Construction and Landscaping Ltd | Construction | 2025 |
| Shield Fire Solutions Ltd | Construction | 2020 |
| Shilladay Lettings Ltd | Real estate | 2023 |
| Shilozile Ltd | Health & social care | 2023 |
| Shilton Digital Ltd | Information & communication | 2024 |
| Shine Mentorship Ltd | Administrative & support | 2023 |
| Shinecrest Limited | Extraterritorial | 2013 |
| Shining Steps Ltd | Wholesale & retail | 2018 |
| Shipleys Accountancy Group Ltd | Professional & scientific | 2024 |
| Shipleys Advisory Services Ltd | Professional & scientific | 2024 |
| Shipleys HR Services Ltd | Administrative & support | 2025 |
| Shipleys Tax & Accounting Ltd | Professional & scientific | 2024 |
| Shipleys Tax & Accounts Ltd | Professional & scientific | 2024 |
| Shipleys Tax (Sheff) Ltd | Professional & scientific | 2024 |
| Shipleys Tax Accounting Services Ltd | Professional & scientific | 2024 |
| Shipleys Tax Advisers (Sheff) Ltd | Professional & scientific | 2024 |
| Shipleys Tax Advisors Ltd | Professional & scientific | 2024 |
| Shipleys Tax Holdings Ltd | Financial services | 2024 |
| Shipleys Tax Partners Ltd | Professional & scientific | 2024 |
| Shipleys Tax Planning (Sheff) Ltd | Professional & scientific | 2024 |
| Shipleys Tax Planning Ltd | Professional & scientific | 2007 |
| Shiraz Foods Ltd | Hospitality | 2023 |
| Shires Pest Control & Wildlife Management Ltd | Administrative & support | 2014 |
| Shirley Pool Court Limited | Real estate | 2010 |
| Shoal Safety in Numbers Ltd | Professional & scientific | 2019 |
| Shona Garner Coaching Services Ltd | Education | 2003 |
| Shony-Bares Limited | Real estate | 1998 |
| Shoppaystore Ltd | Wholesale & retail | 2025 |
| Shopwiny Ltd | Wholesale & retail | 2026 |
| Shoreline Ventures Limited | Financial services | 2018 |
| Short LET Facilities Management Ltd | Real estate | 2024 |
| Short Storage Limited | Real estate | 2018 |
| Showlocus Ltd. | Financial services | 2015 |
| Showtimeuk Ltd | Arts & recreation | 2022 |
| Shree SAI Convenience UK Ltd | Wholesale & retail | 2023 |
| Shreeram Transport Ltd | Transport & logistics | 2021 |
| Shutt Velo Rapide Limited | Wholesale & retail | 2009 |
| Shuttleworth Drive Management Company Limited | Households | 2025 |
| Shyne Barber Limited | Transport & logistics | 2018 |
| SIA Fast Ltd | Transport & logistics | 2026 |
| Sialpro Ltd | Wholesale & retail | 2023 |
| Siam Thai Massage Ltd | Other services | 2011 |
| Siaser Trans Limited | Transport & logistics | 2025 |
| Sicilian C R D Pizza Limited | Hospitality | 2020 |
| Sidegrove Limited | Transport & logistics | 2004 |
| Sidelands Farm Management Limited | Real estate | 2021 |
| Sides Estates Ltd | Real estate | 2026 |
| Sides on Smoke Ltd | Hospitality | 2026 |
| Sielu Driving Ltd | Transport & logistics | 2023 |
| Sier Financial Services Ltd. | Financial services | 2015 |
| Sigbox Ltd | Construction | 2022 |
| SIGHTCARE2000.COM Limited | Professional & scientific | 2000 |
| Sigma Houses Ltd | Real estate | 2024 |
| Sigma Solutions Software Ltd | Information & communication | 2024 |
| Signal Alarms Limited | Administrative & support | 2000 |
| Signalgrid Data Ltd | Information & communication | 2026 |
| Signalling Delivery Solutions Ltd | Construction | 2022 |
| Signature Rail Engineering Services Ltd | Construction | 2021 |
| Signdesign Doncaster Limited | Manufacturing | 2012 |
| Signet Construction Group Ltd | Construction | 2015 |
| Signet Industrial Distribution (Holdings) Ltd. | Financial services | 1998 |
| Signet Industrial Distribution (Scunthorpe) Limited | Wholesale & retail | 2002 |
| Signet Industrial Distribution Limited | Other services | 1998 |
| Signet Trade Supply Limited | Other services | 2002 |
| Signportal Limited | Wholesale & retail | 2011 |
| Signsystems Limited | Manufacturing | 2004 |
| Signum Facilities Management Limited | Professional & scientific | 2012 |
| Signum Properties Limited | Hospitality | 2023 |
| Signumnex Limited | Professional & scientific | 2017 |
| Siiap Limited | Transport & logistics | 2023 |
| Silgan Closures UK Holdings Limited | Professional & scientific | 2003 |
| Silgan Closures UK Limited | Manufacturing | 1991 |
| Silicon Asset Management Limited | Administrative & support | 2020 |
| Silke & Co Ltd | Professional & scientific | 2007 |
| Silke Holdings Ltd | Financial services | 2015 |
| Silke Referrals Limited | Professional & scientific | 2015 |
| Silkstone Ltd | Real estate | 2016 |
| Silky Health & Beauty Ltd | Extraterritorial | 2014 |
| Silmere Ltd | Professional & scientific | 2016 |
| Siltrans GDS Ltd | Transport & logistics | 2023 |
| Silvano Transport Limited | Transport & logistics | 2015 |