| Energize Amenity Limited | Wholesale & retail | 2025 |
| Energy Electrical Contractors Ltd | Construction | 2020 |
| Energy Save Experts Limited | Administrative & support | 2015 |
| Energy Service GP Ltd | Professional & scientific | 2012 |
| Energy Travel Ltd. | Administrative & support | 2020 |
| Energy Ventures NO1. Limited | Professional & scientific | 2023 |
| Enersave Distribution Limited | Professional & scientific | 2016 |
| Enertek Limited | Information & communication | 2006 |
| ENG Traders Ltd | Wholesale & retail | 2022 |
| Engage Daycentre Limited | Health & social care | 2016 |
| Engage HR Solutions Ltd | Administrative & support | 2023 |
| Engine Mobile Ltd | Information & communication | 2017 |
| Engineer Flow Limited | Construction | 2026 |
| Engineered Fabrications Ltd. | Manufacturing | 2016 |
| Engineered Franchise Ltd | Education | 2025 |
| Engineered Learning 18 Shop Limited | Education | 2014 |
| Engineered Learning 25 Shop Ltd. | Education | 2017 |
| Engineered Learning Franchise Ltd | Education | 2021 |
| Engineered Learning Ltd. | Education | 2013 |
| Engineered Racing Ltd. | Education | 2016 |
| Engineered Training 7 Shop CIC | Education | 2018 |
| Engineerick Limited | Information & communication | 2024 |
| Engineering Business Support Limited | Professional & scientific | 2011 |
| Engineering Consultancy Services Limited | Construction | 2019 |
| Engineering LDB Ltd | Professional & scientific | 2024 |
| Engineering Planning Services Limited | Professional & scientific | 2025 |
| Engineering Quality Visions Ltd | Professional & scientific | 2016 |
| Engvalley INT Ltd | Information & communication | 2024 |
| Enhance Aesthetics Medical Services Limited | Health & social care | 2014 |
| Enhanced Pharm Services and Aesthetics Limited | Public administration | 2023 |
| Enhanced Valeting Operations Ltd | Wholesale & retail | 2021 |
| Enigma Seven Ltd | Professional & scientific | 2022 |
| Enjy Healthcare Ltd | Health & social care | 2023 |
| Enlightened Space Ltd | Wholesale & retail | 2025 |
| Enlightened Windows Limited | Wholesale & retail | 2015 |
| Enlightenment Education Ltd | Administrative & support | 2019 |
| Enneurope Holdings Limited | Professional & scientific | 2010 |
| Enneurope Limited | Professional & scientific | 2001 |
| Ennk Logistics Ltd | Administrative & support | 2025 |
| Enquiry CX Limited | Administrative & support | 2026 |
| Enrich Digital Technologies Ltd | Information & communication | 2016 |
| Enscidien Limited | Professional & scientific | 2016 |
| Ensco 1032 Limited | Other services | 2013 |
| Ensco 1357 Limited | Professional & scientific | 2019 |
| Ensembl Payments Ltd | Information & communication | 2026 |
| Ensign 1991 Ltd | Professional & scientific | 2024 |
| Enspired Consulting Ltd | Professional & scientific | 2023 |
| ENT Care Services Limited | Health & social care | 2019 |
| Entercare Limited | Real estate | 1990 |
| Enterfries Limited | Hospitality | 2016 |
| Enterhaven Limited | Construction | 1986 |
| Enterprise 1699 Ltd | Real estate | 2021 |
| Enterprise 1706 Ltd | Real estate | 2021 |
| Enterprise 2406 Ltd | Real estate | 2021 |
| Enterprise Content Consultancy Limited | Information & communication | 2015 |
| Enterprise Developer Group Limited | Information & communication | 2008 |
| Enterprising 4 Change | Administrative & support | 1995 |
| Entervents Limited | Arts & recreation | 2022 |
| Entotem Limited | Information & communication | 2013 |
| Entrepreneurs Black Book Ltd | Professional & scientific | 2020 |
| Enverigo Ltd | Professional & scientific | 2022 |
| Enviro Recycling Limited | Wholesale & retail | 2020 |
| Enviro Safety Partnership Limited | Information & communication | 2008 |
| Enviro Vehicle Hire Limited | Professional & scientific | 2012 |
| Enviroclenz Ltd | Administrative & support | 2013 |
| Enviroflex Limited | Manufacturing | 1998 |
| Environmental Health Partnership Limited | Health & social care | 2001 |
| Environmental I.T Solutions Ltd | Wholesale & retail | 2020 |
| Envisio Consulting Limited | Real estate | 2018 |
| EP Driveway Ltd | Real estate | 2024 |
| EP Property Solutions Ltd | Real estate | 2019 |
| EPC Energyx Ltd | Public administration | 2023 |
| Ephraimites Homes Limited | Real estate | 2025 |
| Epic Agency Ltd | Professional & scientific | 2026 |
| Epic Surveys Limited | Administrative & support | 2017 |
| Epique Creations Ltd | Professional & scientific | 2025 |
| Epma Consulting Ltd | Information & communication | 2022 |
| Epoch Comics Ltd | Information & communication | 2022 |
| Epos by Smart Utilities Midlands Ltd | Information & communication | 2025 |
| Eposal Holdings Ltd | Financial services | 2021 |
| Epoxy Wizard Limited | Construction | 2019 |
| Eprologic IT & Security Services Ltd | Information & communication | 2011 |
| EPT Derby Building & Trade Ltd | Construction | 2026 |
| EPY Property Ltd | Real estate | 2025 |
| Eqal Group Ltd | Wholesale & retail | 2026 |
| EQS (UK) Limited | Professional & scientific | 1994 |
| EQS Investments Limited | Real estate | 2012 |
| Equality and Diversity Care Ltd | Administrative & support | 2016 |
| Equans Properties Ltd | Real estate | 2025 |
| Equatoria Woodland Ltd | Agriculture & fishing | 2026 |
| Equestrian Life Ltd | Wholesale & retail | 2024 |
| Equestrian Protection Solutions Ltd | Financial services | 2018 |
| Equine Massage Works Ltd | Other services | 2021 |
| Equinox Associates and Partners Limited | Professional & scientific | 2021 |
| Equinox Medical Limited | Health & social care | 2010 |
| Equipilates Limited | Arts & recreation | 2012 |
| Equipoise Training Limited | Professional & scientific | 2011 |
| Equiscapes Ltd | Administrative & support | 2025 |
| Equites (Basingstoke) Ltd | Real estate | 2019 |
| Equites Newlands (Hoyland) Ltd | Real estate | 2020 |