| Dynamic Content Limited | Information & communication | 2010 |
| Dynamic Mechanical Solutions Ltd | Professional & scientific | 2021 |
| Dynamic Strength Ltd | Manufacturing | 2022 |
| Dyno Boss Ltd | Manufacturing | 2022 |
| Dyvergent Holdings Ltd | Financial services | 2022 |
| Dyzio Road Trans Limited | Transport & logistics | 2022 |
| Dzik Trans Ltd | Transport & logistics | 2022 |
| E & F Ventures Limited | Real estate | 2011 |
| E & J Corp Ltd | Hospitality | 2025 |
| E & J Foods (Derby) Ltd | Wholesale & retail | 2024 |
| E and K Solutions Ltd | Real estate | 2016 |
| E B Wholesale and Catering Ltd | Construction | 2025 |
| E Clarke Building Ltd | Construction | 2026 |
| E F H Russell Limited | Financial services | 2013 |
| E J Clad Limited | Construction | 2016 |
| E K Precision Joinery Limited | Construction | 2026 |
| E M Garden Design Company Limited | Administrative & support | 2015 |
| E Macklin Management Ltd | Agriculture & fishing | 2023 |
| E R Murfin Ltd | Health & social care | 2023 |
| E Safety Training Limited | Other services | 2020 |
| E&A Trucks Ltd | Transport & logistics | 2019 |
| E&C VU Ltd | Other services | 2023 |
| E&H Car Sales Limited | Wholesale & retail | 2024 |
| E&P Ltd | Wholesale & retail | 2020 |
| E'Knect Energy & Electrical Services Ltd | Construction | 2018 |
| E-Business Power Ltd | Wholesale & retail | 2024 |
| E-Cfo Ltd | Professional & scientific | 2017 |
| E-Charge Holdings Limited | Construction | 2022 |
| E-Commerce Official Ltd | Wholesale & retail | 2025 |
| E-Dict Transcription Services Limited | Information & communication | 2003 |
| E-Nails and Spa Derby Ltd | Other services | 2024 |
| E-Nails Derby Limited | Other services | 2019 |
| E-Nails Nottingham Limited | Other services | 2020 |
| E-Sale Emporium Ltd | Wholesale & retail | 2024 |
| E-Volve Networks Limited | Information & communication | 2024 |
| E-Volve Solutions Limited | Information & communication | 2009 |
| E.A.G Services Limited | Manufacturing | 2018 |
| E.C. Pavilions Limited | Real estate | 2025 |
| E.E.T Property Solutions Ltd | Real estate | 2025 |
| E.G.Harrison Limited | Other services | 1941 |
| E.J.P.Accountancy Services Ltd | Professional & scientific | 2013 |
| E.M.A Surveying Limited | Professional & scientific | 2017 |
| E.M.S. (Security Services) Limited | Administrative & support | 1998 |
| E.P.S. (UK) Limited | Professional & scientific | 1985 |
| E2 Auto Car Service Ltd | Wholesale & retail | 2022 |
| E30 IT Solutions Ltd | Other services | 2023 |
| E4S Trading Limited | Administrative & support | 2013 |
| EA Asset Management Limited | Real estate | 2021 |
| EA Floors Ltd | Construction | 2019 |
| Eagle Bay Golf Ltd | Arts & recreation | 2025 |
| Eagle City Cars Ltd | Transport & logistics | 2023 |
| Eagle Star Investments Limited | Real estate | 2019 |
| Eagle View Media Ltd | Information & communication | 2024 |
| Eagleridge Limited | Construction | 1968 |
| Eaglesec Limited | Administrative & support | 2018 |
| Eaglesfield Inns Ltd | Hospitality | 2024 |
| Eaglesgate Property Management Limited | Real estate | 2023 |
| Eaglesgate Training Ltd | Education | 2022 |
| Earcu Ltd | Information & communication | 2009 |
| Eardley & Co Ltd | Professional & scientific | 2013 |
| Earl Rentals Ltd | Real estate | 2025 |
| Earthroot Ltd | Agriculture & fishing | 2026 |
| East Lodge Consultancy Limited | Professional & scientific | 2019 |
| East Midland Cryogenics Limited | Construction | 2015 |
| East Midland Fresh Food Ltd | Wholesale & retail | 2024 |
| East Midland Haulage Ltd | Transport & logistics | 2021 |
| East Midland Superbike Limited | Wholesale & retail | 2002 |
| East Midlands Air Transport Limited | Transport & logistics | 2012 |
| East Midlands Boat Services Limited | Manufacturing | 2021 |
| East Midlands Bridge Academy Limited | Arts & recreation | 2002 |
| East Midlands Building Services Ltd | Construction | 2025 |
| East Midlands Coachworks Limited | Wholesale & retail | 2006 |
| East Midlands Commercial Interiors Limited | Manufacturing | 2024 |
| East Midlands Dance Artist Network C.I.C. | Arts & recreation | 2025 |
| East Midlands Demolition Limited | Construction | 2002 |
| East Midlands Electrical Services Ltd | Construction | 2024 |
| East Midlands Installations Limited | Construction | 2011 |
| East Midlands Institute of Technology | Education | 2022 |
| East Midlands International Airport Limited | Transport & logistics | 1986 |
| East Midlands Jazz Community Interest Company | Arts & recreation | 2009 |
| East Midlands JET Washing Services Limited | Water & waste | 2015 |
| East Midlands Leisure Hire Ltd | Administrative & support | 2018 |
| East Midlands Logistics Centre Limited | Real estate | 2015 |
| East Midlands Plastering Limited | Wholesale & retail | 1994 |
| East Midlands Plumbing 24/7 Limited | Construction | 2025 |
| East Midlands Property Limited | Real estate | 2017 |
| East Midlands Property Solutions Ltd | Real estate | 2015 |
| East Midlands Scaffold Ltd | Construction | 2015 |
| East Midlands Solutions Limited | Construction | 2019 |
| East Midlands Specialist Operations Group Ltd | Administrative & support | 2023 |
| East West House Ltd | Information & communication | 2017 |
| East Works Longbridge Management Company Limited | Households | 2013 |
| Eastern Cuisine (Derby) Limited | Hospitality | 2011 |
| Eastern Cuisine T/A BBQ Express Ltd | Hospitality | 2025 |
| Eastern Europeans Network CIC | Administrative & support | 2015 |
| Easternrange Limited | Extraterritorial | 2020 |
| Easton Services Limited | | 1983 |
| Eastshine Contractor Ltd | Construction | 2024 |
| Eastsun Import Limited | Wholesale & retail | 2015 |
| Eastwood Leisure Group Limited | Hospitality | 2021 |