| Design for Change Limited | Information & communication | 2025 |
| Design Wall Limited | Manufacturing | 2003 |
| Designcore Derby CIC | Information & communication | 2014 |
| Designed Living Holdings Ltd | Financial services | 2022 |
| Designer Clothes Ltd | Wholesale & retail | 2023 |
| Designing Dialogue (S.H.E.D) Community Interest Company | Education | 2020 |
| Desiree Total Limited | Health & social care | 2016 |
| Desitha Devmika Holdings Ltd | Health & social care | 2023 |
| Desousahealthcare Limited | Administrative & support | 2014 |
| Dessert Stop Limited | Hospitality | 2018 |
| Desserts Express Limited | Wholesale & retail | 2020 |
| Desserts Haven Ltd | Hospitality | 2025 |
| Destination Digital Marketing Limited | Professional & scientific | 2020 |
| Destination Leisure Ltd | Arts & recreation | 2018 |
| Destino Health & Fitness Limited | Arts & recreation | 2016 |
| Destiny Investments Ltd | Manufacturing | 2011 |
| Desucla Limited | Information & communication | 2019 |
| Desucla Services 2 Limited | Information & communication | 2023 |
| Detail Oriented Ltd | Wholesale & retail | 2016 |
| Detailingbydamal Ltd | Transport & logistics | 2019 |
| Detailingworx Ltd | Wholesale & retail | 2026 |
| Detatched Ltd | Real estate | 2020 |
| Detty Technologies Ltd | Professional & scientific | 2025 |
| Deufin Ltd | Financial services | 2019 |
| Devagiri Healthcare Limited | Administrative & support | 2012 |
| Devan-Ppt Chemicals Limited | Wholesale & retail | 2005 |
| Developing Talent Limited | Administrative & support | 2008 |
| Deviant Strength & Conditioning Ltd | Arts & recreation | 2017 |
| Devina Solutions Ltd | Information & communication | 2019 |
| Devmac Development Ltd | Information & communication | 2021 |
| Devmac Trading Limited | Information & communication | 2011 |
| Devmarl Controls Ltd. | Professional & scientific | 2013 |
| Devoch Limited | Professional & scientific | 2017 |
| Devon House Investments Ltd | Construction | 2026 |
| Devonshire Court Residence RTM Company Limited | Households | 2013 |
| Devonshirebelper Limited | Hospitality | 2018 |
| Devops Decoded Ltd | Information & communication | 2015 |
| Devspine Ltd | Information & communication | 2026 |
| Devtank Ltd | Manufacturing | 2014 |
| Dewey Solutions Limited | Administrative & support | 2014 |
| DEX Consulting Limited | Professional & scientific | 2011 |
| Dexterre Asia Ltd | Professional & scientific | 2020 |
| Deylami Mental Health Limited | Health & social care | 2023 |
| Deylami Properties Ltd | Real estate | 2020 |
| Dezign Clothing Limited | Wholesale & retail | 2018 |
| DFD (UK) Limited | Real estate | 2009 |
| DFE Electrical Ltd | Construction | 2016 |
| DFF Takeaway Ltd | Hospitality | 2025 |
| DFS Consulting Limited | Professional & scientific | 2022 |
| DFW Construction (Midlands) Limited | Construction | 2025 |
| DFW Furniture & Flooring Ltd | Wholesale & retail | 2000 |
| DFW Group Limited | Financial services | 2025 |
| DG Light Haulage Limited | Transport & logistics | 2013 |
| DGC Manufacturing Limited | Manufacturing | 2014 |
| Dgmep Services Ltd | Construction | 2019 |
| DGR Landscaping Limited | Administrative & support | 2009 |
| Dgsb Electrical Limited | Construction | 2026 |
| DGT Estates Ltd | Real estate | 2026 |
| DH Group 4 Furniture Ltd | Manufacturing | 2026 |
| DH Style & Design Ltd | Wholesale & retail | 2022 |
| Dhak Music & Film Productions Ltd | Information & communication | 2026 |
| Dhaliwal Building Services Ltd | Construction | 2023 |
| Dhamrait Criminal Defence Services Limited | Professional & scientific | 2019 |
| Dhamrait Developments Ltd | Real estate | 2026 |
| Dhamrait Group Real Estate Ltd | Real estate | 2019 |
| Dhamrait Holdings Ltd | Financial services | 2022 |
| Dhamrait Property Management Services Limited | Real estate | 2019 |
| Dhan Puran Niwas Ltd | Real estate | 2018 |
| Dhana Holdings Ltd | Financial services | 2025 |
| Dhanaram UK Private Limited | Hospitality | 2023 |
| Dhanju Property Ltd | Real estate | 2025 |
| Dhanoa Transport Limited | Transport & logistics | 2016 |
| Dharam and Co Home Improvements Limited | Construction | 2019 |
| Dharl Limited | Hospitality | 2012 |
| DHC Innovations Ltd | Manufacturing | 2016 |
| DHE Property Ltd | Real estate | 2025 |
| Dhear Properties Ltd | Construction | 2025 |
| DHG Aviation Services Ltd | Professional & scientific | 2025 |
| Dhillon Saab Ltd | Construction | 2025 |
| Dhiman Design Limited | Manufacturing | 2025 |
| Dhitree Data Consultancy Services Ltd | Information & communication | 2022 |
| Dhjc Ltd | Energy | 2013 |
| Dhru and GI Ltd | Real estate | 2020 |
| DHT Mobiles Limited | Manufacturing | 2025 |
| DHU 4FED Urgent Care (West Leicestershire) C.I.C. | Health & social care | 2018 |
| DHU ELR GP FED CIC | Health & social care | 2023 |
| DHU Health Care C.I.C. | Health & social care | 2006 |
| DHU Urgent Care (Derbyshire) C.I.C. | Health & social care | 2017 |
| DHU Urgent Care (Leicester, Leicestershire & Rutland) C.I.C. | Health & social care | 2017 |
| DI Forsytho Property Investment Ltd | Real estate | 2020 |
| DI Software Ltd | Information & communication | 2015 |
| Di-Care Services Ltd | Health & social care | 2022 |
| Di-Investment Group Ltd | Real estate | 2021 |
| Di.Carpentery Ltd | Manufacturing | 2023 |
| DIA Events Ltd | Other services | 2023 |
| DIA Models Ltd | Other services | 2023 |
| DIA Podcast Ltd | Other services | 2023 |
| DIA Socials Ltd | Other services | 2023 |
| DIA Sound Ltd | Other services | 2023 |
| DIA Studios Ltd | Other services | 2023 |