| D.I.P.T. Limited | Manufacturing | 1978 |
| D.J. Pollard Limited | Construction | 2004 |
| D.J.G. Contracts Limited | Manufacturing | 2015 |
| D.M.J Brickwork (UK) Ltd | Construction | 2010 |
| D.O Property Developments Ltd | Real estate | 2023 |
| D.P. Civil Engineering (Derby) Limited | Construction | 2008 |
| D.T. White Limited | Transport & logistics | 2003 |
| D2N2 Local Enterprise Partnership | Professional & scientific | 2019 |
| D2PSOLUTIONS Ltd | Professional & scientific | 2024 |
| D4L Derby Limited | Education | 2020 |
| DA Coopers Ltd | Wholesale & retail | 2025 |
| DA Corsa Moto Ltd | Wholesale & retail | 2023 |
| DA Hora Family Adventures Ltd | Professional & scientific | 2024 |
| DAB Commercial Ltd | Real estate | 2025 |
| DAB Group Limited | Real estate | 2025 |
| Dacci - Derby African Caribbean Community Initiative CIC | Health & social care | 2024 |
| Dace Investments Limited | Real estate | 2024 |
| Dacegrade Limited | Construction | 1983 |
| Dacha UK Ltd | Real estate | 2023 |
| Dacp Limited | Information & communication | 2002 |
| Dadowah Sons Ltd | Financial services | 2019 |
| Daffodil Cleaning & Maintenance Ltd | Administrative & support | 2024 |
| Daffodils Clothing UK Ltd | Wholesale & retail | 2025 |
| DAG Trading Limited | Wholesale & retail | 2011 |
| DAH Renewable Consulting Ltd | Professional & scientific | 2023 |
| Daher Industrial Services UK Limited | Administrative & support | 1986 |
| Daht Limited | Hospitality | 2003 |
| DAI Driveways Ltd | Administrative & support | 2023 |
| Daily Fresh Hub Limited | Wholesale & retail | 2026 |
| Dailyfresh Derby Limited | Wholesale & retail | 2025 |
| Dailyhealth Limited | Real estate | 2014 |
| Daim Desserts Ltd | Hospitality | 2025 |
| Dainas Properties Limited | Financial services | 2024 |
| Daisy Chain Accountancy Limited | Professional & scientific | 2022 |
| Daisy Chain Group Limited | Wholesale & retail | 2024 |
| Daisy Cottages Ltd | Public administration | 2020 |
| Daizy Enterprise Limited | Health & social care | 2025 |
| Daju Data Systems Ltd | Information & communication | 2025 |
| DAL Ventures Limited | Professional & scientific | 2006 |
| Dalaho Ltd | Wholesale & retail | 2026 |
| Dalbury Investments Limited | Financial services | 2021 |
| Dalchi Healthcare Limited | Health & social care | 2017 |
| Dalchi Living Ltd | Health & social care | 2026 |
| Dale Brook Electrics Ltd | Construction | 2026 |
| Dale Brook Properties Ltd | Real estate | 2024 |
| Dale Road Derby Store Limited | Wholesale & retail | 2025 |
| Dale Road Park Sport and Community Hub Community Interest Company | Arts & recreation | 2023 |
| Daleacre Healthcare Limited | Wholesale & retail | 2016 |
| Daleacre Holdings Limited | Financial services | 2016 |
| Daleacre Medical Services Ltd | Wholesale & retail | 2003 |
| Dalemoor Farm Management Company Limited | Households | 2012 |
| Dales GAS & Electrical Services Limited | Construction | 2007 |
| Daleside Developments Limited | Transport & logistics | 2011 |
| Dalgety Distribution Limited | Wholesale & retail | 2023 |
| Dallas Coventry Limited | Hospitality | 2019 |
| Dalton Electrical Contracting Limited | Construction | 2015 |
| Damage Control (UK) Limited | Construction | 2004 |
| Damar Property Solutions Limited | Real estate | 2018 |
| Dami Trans Midland Ltd | Transport & logistics | 2019 |
| Damian Pabisiak Transport Ltd | Transport & logistics | 2026 |
| Damian Trotter Limited | Households | 2019 |
| Damian With Dogs Limited | Other services | 2025 |
| Damien Walters Film Limited | Arts & recreation | 2024 |
| Dammiesbloom Limited | Wholesale & retail | 2025 |
| Damp Detectives Midlands Ltd | Professional & scientific | 2023 |
| Damsons Coffee House Ltd | Hospitality | 2020 |
| DAN Robinson Ltd | Manufacturing | 2016 |
| Dan's Driving School Limited | Education | 2024 |
| Danarc Enterprises Ltd | Wholesale & retail | 2026 |
| Danastyle Limited | Manufacturing | 2020 |
| Dance Alliance Ltd | Arts & recreation | 2022 |
| Dancing Duck Beer Ltd | Manufacturing | 2009 |
| Dancing Duck Holdings Ltd | Manufacturing | 2014 |
| Dandelion Stationery Ltd | Manufacturing | 2017 |
| Daneland Limited | Real estate | 2019 |
| Daneliacarsales Limited | Wholesale & retail | 2025 |
| Danemel Homes Limited | Construction | 2018 |
| Daniah Medicals Limited | Health & social care | 2012 |
| Danida Services Limited | Administrative & support | 2018 |
| Daniel Bigham Engineering Services Ltd | Professional & scientific | 2025 |
| Daniel Burton Photography Ltd | Information & communication | 2006 |
| Daniel Dore Coaching Ltd | Health & social care | 2018 |
| Daniel MK Cars Limited | Construction | 2024 |
| Danii’S Builders Ltd | Construction | 2026 |
| Daniyal Transport Limited | Transport & logistics | 2023 |
| Dannies Estates Ltd | Real estate | 2019 |
| Danny's Property Management Ltd | Real estate | 2026 |
| Danov Ltd | Construction | 2025 |
| Dansom Ltd | Wholesale & retail | 2025 |
| Dante Media Group Limited | Professional & scientific | 2018 |
| Dante Rigs Consultancy Ltd | Professional & scientific | 2025 |
| Dantom Express Ltd | Transport & logistics | 2026 |
| Danway Ltd | Administrative & support | 2025 |
| Danya 17 Limited | Other services | 2025 |
| DAR UL Madinah Derby Ltd | Education | 2022 |
| DAR88BAR Ltd | Transport & logistics | 2025 |
| Darban INT Ltd | Hospitality | 2025 |
| Darbar Estates Limited | Real estate | 2026 |
| Darchir Communications Limited | Professional & scientific | 2024 |
| Darden Holdings Limited | Financial services | 2020 |