| Codemakers Limited | Information & communication | 2008 |
| Codeneo Limited | Education | 2025 |
| Coding Sense Ltd | Information & communication | 2022 |
| Codnia Food Ltd | Hospitality | 2024 |
| Codr Ltd | Information & communication | 2014 |
| Coffee Events Ltd | Manufacturing | 2025 |
| Cogent Financial Solutions Ltd | Financial services | 2020 |
| Cognisant Consulting Ltd | Information & communication | 2016 |
| Cognitive Behaviour Therapy 24-7 Limited | Health & social care | 2010 |
| Cognitive SAP Solutions Ltd | Administrative & support | 2017 |
| Cognitus Property Solutions Ltd | Real estate | 2025 |
| Coldasever Limited | Information & communication | 2025 |
| Coldstore Investments Ltd | Financial services | 2022 |
| Cole and IVY Property Developments Limited | Construction | 2024 |
| Cole Electrical (Derby) Limited | Construction | 2016 |
| Colebourne Building Solutions Limited | Construction | 2015 |
| Colebourne Construction Limited | Construction | 1998 |
| Coles & Co Eatery Ltd | Hospitality | 2024 |
| Coles Distribution Limited | Wholesale & retail | 2006 |
| Colin Gamble Properties Limited | Mining & quarrying | 1997 |
| Collaborations Grace Ltd | Health & social care | 2017 |
| Collaborative Wealth Limited | Financial services | 2019 |
| Colleague Box Limited | Manufacturing | 2014 |
| Collector Creations Ltd | Manufacturing | 2026 |
| Collectorscornermelbourne Ltd | Wholesale & retail | 2026 |
| Collingtree Homes Ltd | Construction | 2025 |
| Collingwood Grange Management Company Limited | Households | 2020 |
| Collycroft Properties and Investments Ltd | Real estate | 2025 |
| Collyers Nurseries Limited | Wholesale & retail | 2025 |
| Colombo Horizon Properties Ltd | Real estate | 2024 |
| Colombo House Holdings Ltd | Professional & scientific | 2026 |
| Colombo House Limited | Real estate | 2003 |
| Colombo Street Catering Ltd | Hospitality | 2022 |
| Colombo Street Derby Ltd | Hospitality | 2025 |
| Colombo Street Ltd | Wholesale & retail | 2018 |
| Colombo Street Shop Ltd | Wholesale & retail | 2022 |
| Coloured Square Limited | Administrative & support | 2008 |
| Combined Care and Respite Services Ltd | Health & social care | 2019 |
| Combined Community Housing C.I.C. | Administrative & support | 2021 |
| Combined Health Ltd. | Health & social care | 2017 |
| Come Chop Grills Limited | Hospitality | 2023 |
| Comech Group Ltd | Professional & scientific | 2021 |
| Comech Metrology Limited | Transport & logistics | 2005 |
| Comech Retail Limited | Wholesale & retail | 2019 |
| Comech Services Ltd | Professional & scientific | 2021 |
| Comentra Development Ltd | Professional & scientific | 2024 |
| Cometpac Limited | Wholesale & retail | 2025 |
| Comex 2000 (UK) Limited | Manufacturing | 1999 |
| Comex Civils Limited | Extraterritorial | 2019 |
| Comfa Limited | Professional & scientific | 2022 |
| Comfort Carpets Derby Ltd | Wholesale & retail | 2022 |
| Comfort Residential and Commercial Finance Ltd | Financial services | 2022 |
| Comfort Residential Ltd | Real estate | 2025 |
| Comforting Homes Ltd | Real estate | 2023 |
| Comfy Quarters Ltd | Real estate | 2023 |
| Comityhearts Care Services Ltd | Health & social care | 2020 |
| Command Coaching Ltd | Health & social care | 2023 |
| COMMIT2CARE Services Ltd | Health & social care | 2016 |
| Common Farm Courtyard Ltd | Households | 2024 |
| Commonwealth Boxing Academy & Suite Ltd | Arts & recreation | 2023 |
| Commonwealth Centre Social Enterprise Community Interest Company | Health & social care | 2006 |
| Commtracts Limited | Information & communication | 2010 |
| Communicate Therapeutics Ltd | Health & social care | 2024 |
| Communication & Control Engineering Co. Limited | Extraterritorial | 1992 |
| Community Action Derby Ltd | Other services | 1994 |
| Community Action Derbyshire Ltd | Health & social care | 2018 |
| Community Health Network Ltd | Health & social care | 2024 |
| Community Living Trust | Hospitality | 2015 |
| Community One Limited | Other services | 2020 |
| Community ONE1 Ltd | Education | 2026 |
| Community Seeds Ltd | Professional & scientific | 2010 |
| Community Sport Outreach Programme Ltd | Arts & recreation | 2020 |
| Community Sports Enterprise C.I.C. | Arts & recreation | 2024 |
| Compacc Systems Limited | Professional & scientific | 1995 |
| Company Protection Limited | Financial services | 2023 |
| Compare Ethics Ltd | Information & communication | 2018 |
| Compare Home Insurance Limited | Financial services | 2022 |
| Comparisonmarket Ltd | Information & communication | 2026 |
| Compartment Fire Limited | Public administration | 2005 |
| Compass Consult (Employability and Skills) Ltd | Professional & scientific | 2026 |
| Compassco Limited | Hospitality | 2012 |
| Compassion at Heart Ltd | Health & social care | 2022 |
| Compassionate Helpers Ltd | Health & social care | 2025 |
| Compassionate Mind Training Ltd | Health & social care | 2014 |
| Compassionate Wellbeing Limited | Health & social care | 2011 |
| Compchess Automation Engineers Ltd | Manufacturing | 2025 |
| Complete Car Cosmetics Ltd | Wholesale & retail | 2007 |
| Complete Computer Solutions (Derby) Limited | Information & communication | 2007 |
| Complete Rail IT Solutions Ltd | Professional & scientific | 2025 |
| Complete Test Solutions Ltd | Professional & scientific | 2020 |
| Complex Information Systems Consulting UK Ltd | Information & communication | 2010 |
| Complyedge AI Limited | Information & communication | 2025 |
| Computer Information Associates Limited | Administrative & support | 2018 |
| Computer Repairs Derby Limited | Other services | 2014 |
| Concept Decor Ltd | Wholesale & retail | 2013 |
| Concept Infotech Services Ltd | Information & communication | 2006 |
| Concept PPF Limited | Manufacturing | 2020 |
| Concept Security Logistics Limited | Administrative & support | 2013 |
| Concept Visual Management Ltd | Manufacturing | 2012 |
| Concepts Design Agency (UK) Limited | Professional & scientific | 2020 |