| Clickconnect Ltd | Wholesale & retail | 2024 |
| Clicky Time Ltd | Information & communication | 2024 |
| Clifford Manufacturing Solutions Limited | Professional & scientific | 2010 |
| Clifton Design Build and Renovate Limited | Construction | 2021 |
| Clifton Property and Land Limited | Real estate | 2023 |
| Cliikk Accident Repair Centre Ltd | Wholesale & retail | 2022 |
| Climadoor Limited | Wholesale & retail | 2018 |
| Climb Property Investments Ltd | Real estate | 2019 |
| Clinic Companion Ltd | Information & communication | 2025 |
| CLINIC167 Ltd | Other services | 2021 |
| Clinical Care Limited | Health & social care | 2010 |
| Clinical Metrics Ltd | Administrative & support | 2019 |
| Clinicohealth Ltd | Health & social care | 2011 |
| Clinton House Management Ltd | Households | 2023 |
| Clinton House Properties Ltd | Real estate | 2017 |
| CLJ Retail Consulting Ltd | Professional & scientific | 2025 |
| CLL (Recruitment) Ltd | Administrative & support | 2017 |
| Cllw Properties Limited | Real estate | 2021 |
| Cloaked Cabin Gifts Ltd. | Wholesale & retail | 2019 |
| Clock Xpress Ltd | Hospitality | 2025 |
| Cloth ZAN Limited | Wholesale & retail | 2019 |
| Clotheshub Ltd | Wholesale & retail | 2024 |
| Clothing 4 Work Limited | Manufacturing | 2003 |
| Clothworks (Derby) Limited | Manufacturing | 1988 |
| Cloud 9 Computing Ltd | Information & communication | 2015 |
| Cloud Central Convergence Ltd | Other services | 2002 |
| Cloud Decisions Ltd | Administrative & support | 2020 |
| Cloud Decisions US Ltd | Administrative & support | 2023 |
| Cloud Market Limited | Wholesale & retail | 2023 |
| Cloud Next Limited | Administrative & support | 2008 |
| Cloud Orca Limited | Information & communication | 2018 |
| Cloud Town 23 Ltd | Wholesale & retail | 2025 |
| Cloudedequity Group UK Ltd | Wholesale & retail | 2025 |
| Cloudnet IT Services Ltd | Information & communication | 2018 |
| Cloudoko Ltd | Information & communication | 2014 |
| Cloudplm Ltd | Information & communication | 2022 |
| Cloudscape Limited | Manufacturing | 2019 |
| Cloudware Limited | Information & communication | 2015 |
| Clough Promotions Limited | Other services | 1980 |
| Clove Property Ltd | Real estate | 2025 |
| Clovelly Court Management Company Limited | Real estate | 2004 |
| Clover Leaf Farm Ltd | Agriculture & fishing | 2020 |
| Clowes Designs Limited | Professional & scientific | 2024 |
| Clowns Children's Centre (Ironville) Limited | Other services | 2002 |
| Clowns Children's Centres Limited | Other services | 2002 |
| Clowns Nursery Limited | Administrative & support | 2001 |
| CLP Derby Ltd | Health & social care | 2011 |
| CLT Trading Ltd | Hospitality | 2020 |
| Club Huddle Ltd | Information & communication | 2026 |
| Clubbuzz Limited | Information & communication | 2009 |
| Clubhub Limited | Information & communication | 2018 |
| Clumber Holiday Park Limited | Hospitality | 2023 |
| CM Autos (Midlands) Limited | Wholesale & retail | 2023 |
| CM Commercial Investments Limited | Real estate | 2018 |
| CM Frazer Limited | Financial services | 2024 |
| CM Steel Frames and Cladding Ltd | Construction | 2025 |
| CM Utilities Limited | Construction | 2001 |
| CMA Electrics Ltd | Construction | 2020 |
| CMB Electrical Services (Derby) Ltd | Construction | 2014 |
| Cmcc Group Limited | Financial services | 2023 |
| Cmce Properties Ltd | Real estate | 2025 |
| CMF Investments Limited | Construction | 2015 |
| CMV Property Services Limited | Construction | 2020 |
| CNC Construction (Midlands) Limited | Construction | 2024 |
| CNC Experts Ltd | Manufacturing | 2016 |
| Cnep Ltd | Real estate | 2021 |
| CNP Investments Limited | Professional & scientific | 2016 |
| Co Investments Limited | Real estate | 2024 |
| Co-Operative Independent Financial Solutions Ltd | Financial services | 2012 |
| Co-Operative Wealth Management Ltd | Financial services | 2012 |
| Co-Treetment Ltd | Agriculture & fishing | 2019 |
| CO2 Commercial Limited | Extraterritorial | 2008 |
| Coach Comparison Ltd | Information & communication | 2026 |
| Coach House Rural Enterprises Limited | Financial services | 2025 |
| Coaches in Kind C.I.C. | Education | 2023 |
| Coaching Academy Ltd | Education | 2023 |
| Coaching With Christianne Ltd | Extraterritorial | 2023 |
| Coachlands Limited | Professional & scientific | 2020 |
| Coachuna Ltd | Information & communication | 2024 |
| Coachway Homes Limited | Real estate | 2021 |
| Coalville Town Youth Football Club Ltd | Arts & recreation | 2020 |
| Coast & Countries Properties Ltd. | Real estate | 2020 |
| Coast Services (UK) Limited | Administrative & support | 2014 |
| Coast to Coast Cleaning Services Ltd | Administrative & support | 2020 |
| COAST2COAST Management Ltd | Administrative & support | 2025 |
| Coastal Wave Properties Ltd | Real estate | 2024 |
| Cobalt (Eco) Ltd | Agriculture & fishing | 2026 |
| Cobalt Estates (Kenilworth) Limited | Construction | 2002 |
| Cobalt Estates (Stafford) Limited | Construction | 2000 |
| Cobalt Estates Residential Limited | Real estate | 2011 |
| Cobra Enterprises Ltd | Arts & recreation | 2015 |
| Coburn Holdings Limited | Professional & scientific | 2022 |
| Cocco Salons Limited | Other services | 2011 |
| Cocklebank Conservations Limited | Extraterritorial | 1967 |
| Coco Bello Skin Company Ltd | Other services | 2021 |
| Coco Driving Ltd | Transport & logistics | 2015 |
| Cocoon Property Services Limited | Households | 2020 |
| Coda Project Solutions Limited | Construction | 2014 |
| Coded Merit Ltd | Information & communication | 2021 |
| Codelab Educare Ltd | Wholesale & retail | 2026 |