| Urban Living Derby Ltd | Real estate | 2024 |
| Urban Living Homes Ltd | Real estate | 2025 |
| Urban Radiance Aesthetics Ltd | Other services | 2022 |
| Urban Renewal Living Limited | Financial services | 2023 |
| Urban ZAK Ltd | Real estate | 2024 |
| Urbane Haus Ltd | Real estate | 2026 |
| Urbanli Design Ltd | Information & communication | 2026 |
| Urgup Kebab Ltd | Hospitality | 2018 |
| Urist Mcgeorge Ltd | Information & communication | 2021 |
| URM Consulting Services Ltd | Information & communication | 2005 |
| Urooj Kamran Ltd | Health & social care | 2009 |
| Urotechnology Limited | Health & social care | 2023 |
| Ursus Construction & Management Ltd | Construction | 2020 |
| USA Car Wash (Derby) Limited | Other services | 2018 |
| Usagroupderby Limited | Hospitality | 2025 |
| Usarya Polska International Ltd | Manufacturing | 2023 |
| USC Trading Company Limited | Transport & logistics | 2019 |
| Useful Nonsense Ltd | Information & communication | 2025 |
| User First Design Ltd | Information & communication | 2019 |
| Usgroupcroydon Limited | Hospitality | 2025 |
| USM Holdings Limited | Construction | 2021 |
| Usman Cars Ltd | Transport & logistics | 2026 |
| Ustoo Ltd | Professional & scientific | 2020 |
| Utility Scan Limited | Extraterritorial | 2011 |
| Utopia Brands Ltd | Wholesale & retail | 2018 |
| Utopia Festivals Limited | Arts & recreation | 2019 |
| Uttoxeter Estates Limited | Real estate | 1992 |
| Uttoxeter Grocery Store Ltd | Hospitality | 2024 |
| UV-TI02 Ltd | Professional & scientific | 2024 |
| Uxbridge Meyer Publications Limited | Information & communication | 2024 |
| Uxbridge Street Limited | Wholesale & retail | 1983 |
| UXR Ltd | Information & communication | 2014 |
| Uzairs Turk Limited | Hospitality | 2026 |
| Uzma Trade Ltd | Professional & scientific | 2024 |
| Uzmania Lounge Dessert and Shisha Ltd | Hospitality | 2022 |
| Uzmania Lounge Ltd | Hospitality | 2021 |
| Uzmania Ltd | Construction | 2026 |
| V and G Management Limited | Professional & scientific | 2016 |
| V and N Consultancy Limited | Health & social care | 2020 |
| V E Price Limited | Financial services | 2025 |
| V N Mychajlow Ltd | Construction | 2006 |
| V R Medics Ltd | Health & social care | 2009 |
| V Selective Limited | Professional & scientific | 2005 |
| V Shack Limited | Hospitality | 2021 |
| V&D Derbyshire Properties Ltd | Real estate | 2024 |
| V&S Trading Ltd | Transport & logistics | 2024 |
| V&T Brother Holding Ltd | Financial services | 2026 |
| V&V Cakes and Desserts Ltd | Manufacturing | 2025 |
| V-Community Limited | Health & social care | 2022 |
| V.A.P.Property Solutions Limited | Real estate | 2018 |
| V.C.C & Associates Ltd | Health & social care | 2010 |
| V.M. Baba Ltd | Wholesale & retail | 2024 |
| V85 Ltd | Information & communication | 2023 |
| Vaam Ltd | Information & communication | 2025 |
| Vaastu Realty Ltd | Real estate | 2020 |
| Vaastu Ventures Ltd | Real estate | 2018 |
| Vaastu Wellness Ltd | Arts & recreation | 2022 |
| Vac-Ex Services Limited | Construction | 2021 |
| Vaclavik Ltd | Manufacturing | 2025 |
| Vaga Group Ltd | Financial services | 2024 |
| Vaid Group Ltd | Financial services | 2026 |
| Vajra Elephant Limited | Information & communication | 2011 |
| Vakobe Ltd | Professional & scientific | 2016 |
| Valcera Ltd | Professional & scientific | 2025 |
| Vale Commerce Ltd | Wholesale & retail | 2026 |
| Valegar Limited | Hospitality | 2022 |
| Valerie Property Investment Limited | Real estate | 2021 |
| Valeriona Ltd | Wholesale & retail | 2026 |
| Valex Tech Services Limited | Professional & scientific | 2025 |
| Validly Ltd. | Information & communication | 2025 |
| Vallee Studios Ltd | Wholesale & retail | 2025 |
| Valters Mitnieks Ltd | Administrative & support | 2015 |
| Valudrive Consultancy Ltd | Professional & scientific | 2017 |
| Value AV Limited | Wholesale & retail | 2014 |
| Value Pick Ltd | Wholesale & retail | 2026 |
| Value UP Construction Ltd | Construction | 2024 |
| Valuemaker Investments LLP | | 2016 |
| Valuemaker Ltd | Financial services | 2015 |
| Valve and Pipeline Services Limited | Extraterritorial | 2020 |
| Van Hire Direct Limited | Administrative & support | 2025 |
| Van Holland Consulting Ltd | Information & communication | 2019 |
| Van Repair Centre Ltd | Wholesale & retail | 2024 |
| Vanfrey Services Ltd | Administrative & support | 2021 |
| Vanguard Assist Ltd | Administrative & support | 2025 |
| Vanguard Property Solutions Ltd | Real estate | 2020 |
| Vanguard Search Limited | Administrative & support | 2015 |
| Vanguard Security and Protection Limited | Administrative & support | 2026 |
| Vanguard Vending Group Ltd | Wholesale & retail | 2026 |
| Vanhatch Management Company (NO. 1) Limited | Real estate | 1983 |
| Vani Custom Cabinets Ltd | Manufacturing | 2024 |
| Vanitha Ganesh Consultancy Services Limited | Health & social care | 2021 |
| Vanity Hills Limited | Wholesale & retail | 2024 |
| Vanquish Capital Partners Ltd | Professional & scientific | 2015 |
| Vanquish Letting Services Limited | Real estate | 2012 |
| Vanstaceapparel Limited | Manufacturing | 2024 |
| Vanta Prestige Ltd | Transport & logistics | 2026 |
| Vantage Developments (Midlands) Limited | Real estate | 2023 |
| Vantage Financial Services Limited | Financial services | 2006 |
| Vantage One Ltd | Administrative & support | 2025 |
| Vantage Point Property Ltd | Real estate | 2023 |