| Spark Artur Limited | Construction | 2023 |
| Spark Mobile Phones Ltd | Wholesale & retail | 2025 |
| Sparkhouse Easy Click Ltd | Wholesale & retail | 2025 |
| Sparkle & Shine Cleaning Limited | Administrative & support | 2025 |
| Sparkle Wave UK Limited | Administrative & support | 2025 |
| Sparkling Clean Global Limited | Administrative & support | 2025 |
| Sparkling Clean Solutions Ltd | Administrative & support | 2017 |
| Sparkling White Limited | Administrative & support | 2025 |
| Sparkuff Ltd | Wholesale & retail | 2023 |
| Sparrow MW Ltd | Transport & logistics | 2023 |
| Sparrowtrans Limited | Transport & logistics | 2020 |
| Spartacus (Services) Limited | Extraterritorial | 2011 |
| Spartacus (UK) Limited | Extraterritorial | 2011 |
| Spartan Fitness Studios Ltd | Other services | 2025 |
| Sparx Property Ltd | Real estate | 2019 |
| Spatam Limited | Health & social care | 2025 |
| Spaul Consulting Limited | Professional & scientific | 2013 |
| Spay Solutions Limited | Information & communication | 2018 |
| SPC Executive Services Ltd | Construction | 2017 |
| Spear Fire Safety Consultant Ltd | Public administration | 2026 |
| Special Care Services Limited | Health & social care | 2003 |
| Special Communications Aquila Limited | Manufacturing | 2025 |
| Special Event Organisers UK Limited | Arts & recreation | 2021 |
| Special Protection Group Ltd | Administrative & support | 2025 |
| Special Purpose Machinery Limited | Extraterritorial | 2026 |
| Specialist Aero Services Ltd | Professional & scientific | 2018 |
| Specialist Bargain Hunter Ltd | Wholesale & retail | 2026 |
| Specialized Engineering Services Limited | Manufacturing | 1999 |
| Specific Properties Limited | Real estate | 2016 |
| Speck Scripts Limited | Information & communication | 2014 |
| Specs at Home UK Limited | Health & social care | 2020 |
| Spectral Ventures Limited | Financial services | 2024 |
| Spectrum Business Solutions Ltd | Professional & scientific | 2021 |
| Spectrum Hearing Ltd | Health & social care | 2021 |
| Spectrum Rise Limited | Wholesale & retail | 2025 |
| Spectrum Textile Services Limited | Other services | 2001 |
| SPEE3D Limited | Extraterritorial | 2013 |
| Speed Engineering Solutions Limited | Professional & scientific | 2016 |
| Speed Plastics Limited | Manufacturing | 1989 |
| Speed Residential Ltd | Real estate | 2022 |
| Speed UK Holdings Ltd | Financial services | 2024 |
| Speedy Glass Limited | Construction | 2014 |
| Speedy Heat (Midlands) Ltd | Construction | 2025 |
| Speedy John Limited | Transport & logistics | 2019 |
| Speedy Underfloor Heating Ltd | Construction | 2026 |
| Spena Limited | Manufacturing | 2019 |
| Spencer & Co Properties Ltd | Real estate | 2026 |
| Spencers Hair Limited | Other services | 2004 |
| Spencetec Ltd | Professional & scientific | 2023 |
| Spero Investments Limited | Information & communication | 2010 |
| Sperry Rail (International) Limited | Professional & scientific | 2002 |
| Sperry Rail Europe Holdings Limited | Professional & scientific | 2011 |
| Spes Vitae Ltd | Manufacturing | 2024 |
| SPH Properties UK Limited | Professional & scientific | 2013 |
| SPH Roofing Contractors Limited | Construction | 2011 |
| Sph-Uk Ltd | Financial services | 2023 |
| Spice Fusion Derby Limited | Hospitality | 2017 |
| Spice Grill Peri Peri Ltd | Hospitality | 2020 |
| Spiced Wine Company Limited | Wholesale & retail | 2010 |
| Spiceville UK Ltd | Wholesale & retail | 2025 |
| Spick and Span (Derby) Limited | Other services | 2013 |
| Spin on IT Records Ltd | Information & communication | 2014 |
| Spinalong Limited | Manufacturing | 1977 |
| Spindletree 1961 Limited | Extraterritorial | 2013 |
| Spinks Group Limited | Financial services | 2023 |
| Spinners Croft Management Company Limited | Households | 2020 |
| Spinners Heath (Apartments) Management Company Ltd | Households | 2020 |
| Spinners Heath Management Company Limited | Households | 2018 |
| Spinney Close Management Company Ltd | Households | 2012 |
| Spiral Land Holdings Ltd | Financial services | 2025 |
| Spiral Renewables Ltd | Professional & scientific | 2022 |
| Spiral Sun Games Ltd | Information & communication | 2017 |
| Spire Environmental Consultants Limited | Professional & scientific | 2012 |
| Spirit Capital Group Ltd | Financial services | 2022 |
| Spirit Capital Limited | Real estate | 2023 |
| SPJ (Derby) Limited | Real estate | 2023 |
| SPK Building Services Limited | Construction | 2007 |
| SPK Global Strategy Ltd | Professional & scientific | 2026 |
| Splash Bathrooms Limited | Wholesale & retail | 2010 |
| Splash Supplies Ltd | Wholesale & retail | 2024 |
| Splashes Pure Water Filtration Ltd | Water & waste | 2020 |
| Spnsr.Net Ltd | Professional & scientific | 2015 |
| Spondon Bistro Ltd | Hospitality | 2018 |
| Spondon Felt Roofing Services Limited | Construction | 2004 |
| Spondon Florists Ltd | Wholesale & retail | 2022 |
| Spondon Smallholding Limited | Real estate | 2012 |
| Spondon Trade Cars Limited | Wholesale & retail | 2024 |
| Spondon Trophies Ltd | Wholesale & retail | 2025 |
| Sport Integrity Matters Limited | Professional & scientific | 2019 |
| Sport Sessions Ltd | Education | 2018 |
| Sportalcom 2026 Ltd | Information & communication | 2026 |
| Sporting Body Ltd | Education | 2018 |
| Sporting Diamonds Limited | Extraterritorial | 2016 |
| Sportingyou Ltd | Information & communication | 2019 |
| Sports FG Ltd | Education | 2025 |
| Sports Gear Ltd | Wholesale & retail | 2023 |
| Sports Tours Limited | Administrative & support | 1989 |
| Sports Tours Overseas Ltd | Administrative & support | 2017 |
| SPORTSLOCKER24.COM Limited | Professional & scientific | 2019 |
| Sportstarsuk Limited | Education | 2017 |