| Sky Vision Care Ltd | Health & social care | 2025 |
| Sky Windows Manufacturing Ltd | Manufacturing | 2025 |
| Skybridge Consulting Limited | Administrative & support | 2024 |
| Skyelineinkk Ltd | Arts & recreation | 2026 |
| Skyeweb Telecommunication Ltd | Wholesale & retail | 2022 |
| Skyler Care Ltd | Health & social care | 2025 |
| Skyline 57 Limited | Manufacturing | 2019 |
| Skyline Mode Ltd | Wholesale & retail | 2025 |
| Skyline Trade & Transport Ltd | Transport & logistics | 2020 |
| Skyrail Pubs Limited | Hospitality | 2020 |
| Skyways Hub Ltd | Information & communication | 2026 |
| Skywayuk Shopfronts Limited | Other services | 2013 |
| SL 38 Ltd | Real estate | 2022 |
| SL Property Hub Ltd | Real estate | 2021 |
| SL Vehicle Movements Ltd | Transport & logistics | 2022 |
| SL22 Ltd | Arts & recreation | 2020 |
| SL84 Properties Ltd | Real estate | 2024 |
| Slalom View Ltd | Financial services | 2024 |
| Slamburger Huddersfield Ltd | Hospitality | 2026 |
| Slaney Associates Limited | Health & social care | 2021 |
| Slate (Eco) Ltd | Agriculture & fishing | 2026 |
| Slater & Partners Limited | Information & communication | 2012 |
| Slater Consulting & Technology Ltd | Information & communication | 2011 |
| Slaterchristiholdings Ltd. | Real estate | 2020 |
| SLAWLESS2019 Limited | Construction | 2019 |
| SLB Lettings Limited | Real estate | 2019 |
| SLC Investments Limited | Real estate | 2025 |
| Sleepsoul Limited | Extraterritorial | 2023 |
| Sleepwell Properties Ltd | Real estate | 2021 |
| Sleeves Limited | Wholesale & retail | 2021 |
| Slice & Go Takeaway Ltd | Hospitality | 2025 |
| Slice of India Limited | Hospitality | 2009 |
| SLJ Logistics Ltd | Transport & logistics | 2026 |
| SLM Music Limited | Information & communication | 2019 |
| SLN Property Limited | Real estate | 2019 |
| SLR Recruitment Ltd | Administrative & support | 2015 |
| SLS (Midlands) Limited | Real estate | 2024 |
| SLS Corporation Ltd | Transport & logistics | 2026 |
| SLS Express Ltd | Transport & logistics | 2023 |
| SLS Property Partners Limited | Real estate | 2026 |
| Sludge Magazine Ltd | Information & communication | 2021 |
| SM Global Int’L Ltd | Information & communication | 2023 |
| SM Prestige Ltd | Transport & logistics | 2023 |
| SM Security and Protection Limited | Administrative & support | 2025 |
| SM Security Training and Recruit Limited | Education | 2025 |
| SM Site Investigation and Geotech Ltd | Professional & scientific | 2023 |
| Sm&M Fairy Healthcare Limited | Health & social care | 2022 |
| SMA (Derby) Ltd | Construction | 2019 |
| Smaahi Ltd | Health & social care | 2023 |
| Small Craft Consultancy Limited | Transport & logistics | 2005 |
| Small Elephant Ltd | Professional & scientific | 2024 |
| Small IS Beautiful Ltd | Education | 2002 |
| Small Plastic Parts Limited | Manufacturing | 2003 |
| Smallbiztek Limited | Information & communication | 1998 |
| Smalley Chase Management Company Limited | Households | 2021 |
| Smalley Cross Ltd | Wholesale & retail | 2005 |
| Smalls Kitchen Ltd | Hospitality | 2025 |
| Smallwood Consultancy Limited | Health & social care | 1999 |
| Smart AI Marketing Ltd | Professional & scientific | 2024 |
| Smart Buy Hub Ltd | Wholesale & retail | 2026 |
| Smart Charging Installations Ltd | Construction | 2025 |
| Smart Confidence Ltd | Information & communication | 2017 |
| Smart Convenience Store Derby Limited | Wholesale & retail | 2026 |
| Smart Electrical (GB) Ltd | Professional & scientific | 2011 |
| Smart Fitness Limited | Arts & recreation | 2025 |
| Smart GB Services Ltd | Professional & scientific | 2024 |
| Smart Gym (Derby) Ltd | Arts & recreation | 2024 |
| Smart Heat Systems Ltd | Construction | 2026 |
| Smart Homes and Housing Limited | Real estate | 2021 |
| Smart Mini Market Ltd | Wholesale & retail | 2023 |
| Smart MIX Concrete Ltd | Transport & logistics | 2021 |
| Smart MOT and Servicing Ltd | Wholesale & retail | 2022 |
| Smart Property & Estate Maintenance Ltd | Construction | 2016 |
| Smart Repair Supplies Limited | Administrative & support | 1996 |
| Smart SAM Ltd | Information & communication | 2021 |
| Smart Sparx Electrical Services Ltd | Construction | 2021 |
| Smart Start Playcare Ltd | Health & social care | 2021 |
| Smart Tech Coatings UK Limited | Wholesale & retail | 2014 |
| Smart Tiles Bathrooms Limited | Wholesale & retail | 2023 |
| Smart Tyres Derby Ltd | Wholesale & retail | 2025 |
| Smart Windscreens Limited | Wholesale & retail | 2002 |
| SMART80 Limited | Real estate | 2023 |
| Smartaxi Limited | Extraterritorial | 2019 |
| Smartbuy Online Ltd | Wholesale & retail | 2026 |
| Smartpaye Ltd | Professional & scientific | 2013 |
| Smartpoint Business Solutions Limited | Information & communication | 2014 |
| Smash Buns Ltd | Hospitality | 2022 |
| Smash Burg Arena Ltd | Hospitality | 2025 |
| Smash Online Ltd | Wholesale & retail | 2023 |
| Smashbomb Limited | Information & communication | 2017 |
| SMB Marchfield Ltd | Information & communication | 2021 |
| Smce Consulting Ltd | Information & communication | 2024 |
| Smedtech Ltd | Manufacturing | 2017 |
| SMG Consultancy Limited | Financial services | 2022 |
| SMG Financial Limited | Professional & scientific | 2026 |
| SMG Vitality Limited | Financial services | 2023 |
| Smguni Services Ltd | Health & social care | 2021 |
| SMH Derby Ltd | Wholesale & retail | 2023 |
| Smile 22 Ltd | Health & social care | 2026 |
| Smiles Teeth Whitening Ltd | Health & social care | 2019 |