| RD Safety Services Ltd | Professional & scientific | 2024 |
| React (Northern) Limited | Manufacturing | 1985 |
| Real Access Ltd | Construction | 2026 |
| Realpay Global Services Limited | Wholesale & retail | 2024 |
| Rebel Housing Limited | Real estate | 2018 |
| REC Consultancy Services Limited | Professional & scientific | 2007 |
| Recognition Marketing and Public Relations LLP | | 2002 |
| Recognition Services Limited | Professional & scientific | 2006 |
| Recommended Roofing Ltd | Construction | 2024 |
| Recreational Ltd | Hospitality | 2025 |
| Recycool (Plasterboard) Limited | Administrative & support | 2010 |
| Red Barnes Training Limited | Extraterritorial | 2024 |
| Red Blast Investments Ltd | Real estate | 2012 |
| Red Button Business School Limited | Professional & scientific | 2019 |
| Red Button Marketing Training Limited | Professional & scientific | 2020 |
| Red DOT Leisure Limited | Professional & scientific | 1987 |
| Red Gym Limited | Arts & recreation | 2018 |
| Red Hot Indian Bar & Grill Ltd | Hospitality | 2019 |
| Red Hot Raffles Ltd | Other services | 2022 |
| Red Mezze Ltd | Hospitality | 2020 |
| Red Riding P&I Ltd | Real estate | 2020 |
| Red Sky Investments Ltd | Extraterritorial | 2021 |
| RED123 Properties Ltd | Real estate | 2016 |
| Redana Studio Group Ltd | Professional & scientific | 2018 |
| Redape Ltd | Wholesale & retail | 2011 |
| Redcar PUB Group Ltd | Hospitality | 2025 |
| Redd Industrial Rope Access Ltd | Manufacturing | 2013 |
| Redforce Drones Ltd | Public administration | 2025 |
| Redford-Tech Limited | Professional & scientific | 2007 |
| Redhills Consulting Limited | Professional & scientific | 2025 |
| Redington Home Services Ltd | Construction | 2013 |
| Redrory Ltd | Professional & scientific | 2019 |
| Redwood Finance Ltd | Financial services | 2018 |
| Redwood Pensions Limited | Professional & scientific | 2023 |
| Redwood Social Housing Limited | Wholesale & retail | 2018 |
| Redworth 4 X 4 Ltd | Wholesale & retail | 2019 |
| Reed Garage Ltd | Wholesale & retail | 2026 |
| Reef & Rise Ltd | Professional & scientific | 2025 |
| Reeves Commercial Ltd | Professional & scientific | 2018 |
| Reeves Management Limited | Real estate | 2024 |
| Refine Clothings Ltd | Wholesale & retail | 2025 |
| Reflections Cleaning Contractors Limited | Administrative & support | 2017 |
| Regal Structures Ltd | Construction | 2017 |
| Regent Maintenance Limited | Construction | 2000 |
| Regent Roofing Limited | Extraterritorial | 1994 |
| Reil Recycling (Number 2) Ltd | Manufacturing | 2023 |
| Reisk Properties Ltd | Real estate | 2025 |
| Rema Secure & Logistics Ltd | Wholesale & retail | 2025 |
| Remove Recycle Ltd | Transport & logistics | 2024 |
| Reneu Aesthetics Ltd | Health & social care | 2016 |
| Renew Property Renovation and Development Limited | Real estate | 2016 |
| Renne Ltd | Manufacturing | 2022 |
| Rennyco Holdings Ltd | Financial services | 2018 |
| Rennyco Limited | Construction | 1986 |
| Rennyco Property Holdings Ltd | Real estate | 2018 |
| Rent 2 Buy Homes Ltd | Real estate | 2020 |
| Rephq Ltd | Information & communication | 2026 |
| Research Independent Financial Services Limited | Financial services | 1991 |
| Reseen Ltd | Professional & scientific | 2023 |
| Resfeber Associates Ltd | Professional & scientific | 2018 |
| Reshaped by Megan and Co Ltd | Other services | 2026 |
| Resilient Business Systems Limited | Information & communication | 2004 |
| Resilient Risk (Projects) Ltd | Professional & scientific | 2021 |
| Resilient Risk Management Ltd | Professional & scientific | 2021 |
| Resin Bound Solutions Limited | Administrative & support | 2025 |
| Resinance Flooring Limited | Construction | 2015 |
| Resource Management Solutions (North East) Ltd | Administrative & support | 2000 |
| Resources Care T/A My Homecare Ddny Ltd | Health & social care | 2016 |
| Responsive Healthcare Ltd | Health & social care | 2015 |
| Restless Spirit Racing Limited | Arts & recreation | 2001 |
| Retro Sweetshop Ltd | Hospitality | 2013 |
| Retrofit Coordinators NE Limited | Construction | 2022 |
| Reuel Nature Ltd | Manufacturing | 2019 |
| Revello Ltd | Wholesale & retail | 2018 |
| Revello Marta Ltd | Construction | 2022 |
| Revere Design and Build Limited | Construction | 2025 |
| Revive 2 Thrive Ltd | Health & social care | 2024 |
| Revolution Football Club Ltd | Arts & recreation | 2021 |
| Reyel Communications Limited | Information & communication | 2014 |
| Reyelcom Ltd | Information & communication | 2023 |
| RG Tuition Ltd | Education | 2026 |
| Rgaret Limited | Wholesale & retail | 2026 |
| Rgjjnortheast Ltd | Arts & recreation | 2023 |
| Rgotts Ltd | Wholesale & retail | 2022 |
| RH Safety Consultants Limited | Professional & scientific | 2013 |
| Rhino Properties Group Limited | Construction | 2020 |
| Rianne Pictures Ltd | Administrative & support | 2021 |
| Richard Brown Decorators Ltd | Construction | 2019 |
| Richard Mands Safety & Training Solutions Ltd | Construction | 2025 |
| Richard Moore IT Consulting Limited | Information & communication | 2024 |
| Richard Perez Carpentry Limited | Construction | 2017 |
| Richardson Professional Services Limited | Wholesale & retail | 2024 |
| Richmondp Limited | Wholesale & retail | 2025 |
| Richnk Global Holdings Limited | Other services | 2025 |
| Ricky G Limited | Real estate | 2018 |
| Rico Homes Ltd | Real estate | 2024 |
| Rider Industrial Ltd | Administrative & support | 2020 |
| Rideready Cycles Ltd | Manufacturing | 2026 |
| Ridlme Ltd | Information & communication | 2025 |
| Right Ideas Consulting Limited | Professional & scientific | 2016 |