| Something Different Miniature Farm C.I.C. | Agriculture & fishing | 2021 |
| South West Dairy Services Limited | Manufacturing | 2006 |
| South West Poultry Installations Limited | Manufacturing | 2004 |
| Southbrook Grove Management Limited | Real estate | 2025 |
| Southill Investments LLP | | 2025 |
| Southwest Restorative Specialist Ltd | Health & social care | 2016 |
| Sovereign Cornish Farm Vanbitz Ltd | Wholesale & retail | 2023 |
| Sovereign Park Home Developments Ltd | Real estate | 2013 |
| Sovereign Park Home Estates Ltd | Real estate | 2013 |
| Sowdens Haulage Ltd | Transport & logistics | 2023 |
| Spec Building Limited | Construction | 2018 |
| Specialist Psychiatry Ltd | Health & social care | 2026 |
| Spectrum Services (SW) Limited | Real estate | 2010 |
| SPH South West Ltd | Professional & scientific | 2019 |
| SPM Private Limited | Wholesale & retail | 2025 |
| Sporting Steps Ltd | Education | 2022 |
| Springbourne Drive Management Company Limited | Households | 2020 |
| Squirrels Childminding (East Butterleigh) Ltd | Health & social care | 2025 |
| Staplegrove Livestock Holdings Limited | Real estate | 2010 |
| Staplegrove Livestock Limited | Agriculture & fishing | 1996 |
| Steam Boiler Services Ltd | Construction | 2012 |
| Steriwaste Ltd | Health & social care | 2002 |
| Steve Talling Consulting Limited | Professional & scientific | 2016 |
| Stillman's (Somerset) Limited | Agriculture & fishing | 1935 |
| Stoked Adventure Group Ltd | Administrative & support | 2013 |
| Stone'D Records Limited | Information & communication | 2010 |
| Stoneman Engineering (S.W.) Limited | Manufacturing | 1998 |
| Stonesmith Agents and Valuers Limited | Real estate | 2008 |
| Stray Star Ltd | Wholesale & retail | 2013 |
| STRETCH2XCESS Limited | Other services | 2008 |
| Stribe Group Limited | Other services | 2025 |
| Stuart Disney Golf Limited | Wholesale & retail | 2008 |
| SUB Fire Ltd | Construction | 2018 |
| Sunny Side View Ltd | Hospitality | 2024 |
| SWA Leisure Limited | Arts & recreation | 2018 |
| SWA Logistics Ltd | Transport & logistics | 2024 |
| Swathed Ltd | Wholesale & retail | 2019 |
| Swellgone Limited | Health & social care | 2025 |
| Swift Spaces Ltd | Real estate | 2023 |
| Synderborough Farm Limited | Agriculture & fishing | 2003 |
| T Breen Associates LLP | | 2019 |
| T1SC Ltd | Information & communication | 2018 |
| Talk Clothing Ltd | Wholesale & retail | 2019 |
| Tango Bravo Services Ltd | Information & communication | 2021 |
| Tanyard Farm Limited | Administrative & support | 2024 |
| Tarplan Limited | Real estate | 2014 |
| Taylor Cunningham Rolt Ltd | Construction | 2024 |
| TC Vapes Ltd | Wholesale & retail | 2026 |
| TCM Contracts Ltd. | Health & social care | 2023 |
| Tekro Limited | Construction | 2022 |
| Terry Martin Investments Ltd | Other services | 2019 |
| Testprecision Ltd | Wholesale & retail | 2025 |
| Thaideefi.Com Ltd | Wholesale & retail | 2022 |
| THE Art of Data Consultancy Limited | Information & communication | 2024 |
| THE Bear Trail Ltd | Arts & recreation | 2015 |
| THE Box and Bar Ltd | Hospitality | 2025 |
| THE Butterleigh Inn | | 2008 |
| THE Circuit Club Ltd | Arts & recreation | 2026 |
| THE Cullompton Walronds Preservation Trust | Health & social care | 1997 |
| THE Cycling Partnership LLP | | 2011 |
| THE Duck and Brush Ltd | Arts & recreation | 2026 |
| THE Flower House Somerset Limited | Wholesale & retail | 2023 |
| THE Leadership Company Limited | Education | 2022 |
| THE Lime Tree Cafe Ltd | Hospitality | 2022 |
| THE Loom Shed Limited | Education | 2020 |
| THE Melanesian Mission | Other services | 2004 |
| THE Mindset for Success Academy Ltd | Education | 2024 |
| THE Rolling Scones Bakery Limited | Manufacturing | 2022 |
| THE Shooting Chauffeur Ltd | Extraterritorial | 2016 |
| THE Skin Health Doctor Ltd. | Health & social care | 2015 |
| THE Talent Firm Limited | Administrative & support | 2018 |
| THE Vault (Devon) Ltd | Transport & logistics | 2020 |
| THE Vault (Wiltshire) Limited | Transport & logistics | 2024 |
| THE Vault UK Holdings Limited | Financial services | 2024 |
| Thesmiledesigners Ltd | Health & social care | 2022 |
| Tideford Miso Limited | Wholesale & retail | 2015 |
| Tigero Ltd | Professional & scientific | 2018 |
| Timber Trail Creations Ltd | Manufacturing | 2024 |
| TIP Top South West Limited | Administrative & support | 2022 |
| Tjhsteelfixing-Formwork Limited | Construction | 2026 |
| Topstylista Image Consultancy Ltd | Other services | 2014 |
| TOR Energy Solutions Limited | Professional & scientific | 2023 |
| TOR Wind Limited | Construction | 2025 |
| Total Building Solutions Southwest Ltd | Construction | 2016 |
| Total Electrical Solutions Southwest Ltd | Construction | 2025 |
| Total Roofing SW Limited | Construction | 2017 |
| Totus Solutions Limited | Administrative & support | 2019 |
| Touchline Media Ltd | Professional & scientific | 2026 |
| Tradewordsai Limited | Information & communication | 2025 |
| Traill Ltd | Information & communication | 2020 |
| Training Solutions (SW) Ltd | Administrative & support | 2023 |
| Transforming Care Partnership Limited | Real estate | 2020 |
| Trebble and Co Limited | Hospitality | 2016 |
| Tree Steps Ahead Ltd | Administrative & support | 2023 |
| Trevor Dodge Electrical Services Ltd | Construction | 2022 |
| Treweek Environmental Consultants Ltd | Professional & scientific | 2015 |
| TRH Property Group Limited | Real estate | 2020 |
| Trident Mortgages & Protection Ltd | Financial services | 2025 |
| Triibe Ltd | Arts & recreation | 2024 |
| Trip ME UP Ltd | Administrative & support | 2023 |