| Rowhook Estates Ltd | Construction | 2020 |
| Roxdene Limited | Administrative & support | 1979 |
| Royal Tunbridge Wells Building Company Limited | Construction | 2010 |
| RPE Solutions Limited | Professional & scientific | 2019 |
| RPK Aesthetics Ltd | Other services | 2025 |
| RSL Loveland Ltd | Financial services | 2025 |
| Ruben Unique Limited | Wholesale & retail | 2022 |
| Rusthall Property Management Limited | Real estate | 2023 |
| Rutland Prime Assets Ltd | Real estate | 2026 |
| Ryder Richardson Ltd | Real estate | 2015 |
| RYE Bay Property Ltd | Real estate | 2015 |
| S & L Stock Management Ltd | Transport & logistics | 2008 |
| S C Hyland Limited | Administrative & support | 2016 |
| S.A. Agate Limited | Professional & scientific | 2005 |
| S.J. Watson (Electrical) Limited | Construction | 1961 |
| Sabre Joinery Ltd | Construction | 2011 |
| Sacred Heart Group Ltd | Wholesale & retail | 2016 |
| Sacred Heart Hardware & DIY Ltd | Wholesale & retail | 2017 |
| Saena Physiotherapy Limited | Other services | 2020 |
| Safetec Direct Limited | Wholesale & retail | 1996 |
| Safetec Vision Limited | Extraterritorial | 2012 |
| Salam Bangla Limited | Hospitality | 2024 |
| Sally Cray Associates Limited | Professional & scientific | 2015 |
| Salti Tech Ltd | Wholesale & retail | 2026 |
| Salvatorex Ltd | Hospitality | 2026 |
| Sampson Care Services Limited | Administrative & support | 2014 |
| Sampson Properties Ltd | Real estate | 2024 |
| Samsons Property Consultants Limited | Other services | 2017 |
| Samuel Ellis Properties Ltd | Construction | 2023 |
| Sandown House Crowborough Limited | Professional & scientific | 1999 |
| Sarpa Digital Limited | Professional & scientific | 2021 |
| Sartor Financial Management Ltd | Professional & scientific | 2023 |
| Savard Consulting Ltd | Professional & scientific | 2025 |
| Saws (U.K.) Limited | Manufacturing | 1989 |
| Saws (UK) Holdings Limited | Real estate | 2002 |
| Scandinavia Direct Limited | Wholesale & retail | 1984 |
| Scarletthr Ltd | Administrative & support | 2025 |
| SCD Associates Ltd | Professional & scientific | 2015 |
| Schusss Ltd | Information & communication | 2025 |
| Scriminger Consulting Limited | Professional & scientific | 2017 |
| Sea Panther Limited | Administrative & support | 2017 |
| Seaxe Properties Limited | Real estate | 2014 |
| Seblec Home & Office Ltd | Construction | 2015 |
| Seblec Ltd | Construction | 2021 |
| SEE6 Ltd | Information & communication | 2016 |
| Seeing Solutions Limited | Real estate | 1998 |
| Seejar Limited | Information & communication | 2024 |
| Selectapension Limited | Information & communication | 2004 |
| Selina Scales Limited | Other services | 2014 |
| Seranna Hair Ltd | Other services | 2021 |
| Serena Joseph Consulting Limited | Professional & scientific | 2020 |
| Servomex Group Limited | Manufacturing | 1987 |
| Sevens Technology Limited | Information & communication | 2019 |
| Shannon's Arms Limited | Information & communication | 2011 |
| Shawten Property Ltd | Real estate | 2019 |
| Shear Management Ltd | Professional & scientific | 2007 |
| Shear Media Limited | Professional & scientific | 2021 |
| Sheppard & Cross Pipe Organ Services Limited | Manufacturing | 2017 |
| Sherlock Court (Crowborough) Limited | Households | 2012 |
| Shield Exteriors Limited | Construction | 2018 |
| Shine AV Limited | Professional & scientific | 2007 |
| Shio Ltd | Wholesale & retail | 2025 |
| Shock Sealants Ltd | Construction | 2024 |
| Shoe String Holdings Limited | Real estate | 2019 |
| Shoreham Homes Limited | Construction | 2021 |
| Siete Properties and Lettings Ltd | Real estate | 2026 |
| Sign IT (Signs & Graphics) Ltd | Manufacturing | 2024 |
| Sign of the Times Publishing Limited | Arts & recreation | 2016 |
| Signal Plumbing Ltd | Construction | 2020 |
| Silana Ltd | Real estate | 2019 |
| Silk Road Training Limited | Public administration | 2019 |
| Silverdale 153 Residents Association Limited | Households | 2005 |
| Silverflight Limited | Professional & scientific | 2011 |
| Silverglade Court Ltd | Construction | 2020 |
| Silverstone Interiors Ltd | Construction | 2025 |
| Simcox Solutions Ltd | Administrative & support | 2024 |
| Simmons Residential Holdings Ltd | Real estate | 2026 |
| Skand Construction Consultancy Limited | Professional & scientific | 2013 |
| Skin Essence Organics UK Limited | Wholesale & retail | 2024 |
| Skip Express Limited | Water & waste | 2001 |
| Skorpion Electrical Contracting Ltd | Construction | 2015 |
| Skyscraper Consulting Limited | Professional & scientific | 2016 |
| Slabshell Ltd | Wholesale & retail | 2025 |
| Smart Choice Construction Group Limited | Construction | 2025 |
| Smart Home Constructions Ltd | Construction | 2024 |
| Smart Managed Limited | Construction | 2023 |
| SMB Healthstyle Limited | Health & social care | 2016 |
| Smiles Sensory and Family Farm Limited | Education | 2023 |
| Smoke and Savor Cafe Limited | Hospitality | 2025 |
| Snoob Ltd | Wholesale & retail | 2023 |
| Social Impact Collective Ltd | Information & communication | 2019 |
| Soft-Cyber Ltd | Information & communication | 2022 |
| Solar Energy Efficiency Developments Ltd | Energy | 2022 |
| Somerset Residential Developments Ltd | Construction | 2012 |
| Sophia & Selina Enterprises Limited | Wholesale & retail | 2020 |
| Soprano 360 Ltd | Wholesale & retail | 2023 |
| Sotheby Homes Ltd | Construction | 2020 |
| South Coast Holidays Ltd | Hospitality | 2021 |
| Southern Automotive Services Ltd | Wholesale & retail | 2019 |
| Southern Electrical Wholesalers Ltd | Wholesale & retail | 2012 |