| Storage Boost (Crewe) Limited | Transport & logistics | 2005 |
| Storm Integration Ltd | Information & communication | 2005 |
| Storms Gate Limited | Information & communication | 2024 |
| Strala Investments Limited | Financial services | 2020 |
| Strata Enterprises Ltd | Professional & scientific | 2010 |
| Strata Renewables Limited | Construction | 2011 |
| Strategic Driving Solutions Limited | Education | 2013 |
| Strategicium Limited | Professional & scientific | 2025 |
| Stratify Advisory Limited | Information & communication | 2026 |
| Stratos-Iq Ltd | Information & communication | 2025 |
| Stratton Oatmont Limited | Hospitality | 2021 |
| Streamline Mechanical Services Ltd | Energy | 2025 |
| Street Track Life Ltd | Wholesale & retail | 2018 |
| Streetcars of Crewe Ltd | Wholesale & retail | 2015 |
| Strickland Commercial Properties Ltd | Real estate | 2025 |
| Strickland Estates Limited | Real estate | 2021 |
| Strippex Ltd | Other services | 2012 |
| Stroisteanu Limited | Transport & logistics | 2020 |
| Strung Instruments Limited | Wholesale & retail | 2006 |
| STS Contractors UK Limited | Agriculture & fishing | 2008 |
| STS Holdings Group UK Ltd | Hospitality | 2024 |
| Stuart Bowler Contractors Limited | Construction | 1983 |
| Stuart Palins Butchers Limited | Manufacturing | 2020 |
| STUARTWILSON1403LOGISTICS Ltd | Transport & logistics | 2024 |
| Stubbs & Sons Property Ltd | Real estate | 2025 |
| Stud Properties Limited | Other services | 2017 |
| Studio 121 Nantwich Ltd | Arts & recreation | 2012 |
| Studio Bowland Limited | Professional & scientific | 2008 |
| Studio Chris Cauchi Ltd | Professional & scientific | 2024 |
| Studio North Creative Ltd | Professional & scientific | 2026 |
| Studio SIX Productions Ltd | Information & communication | 2015 |
| Studio Tadhg Joseph Ltd | Professional & scientific | 2017 |
| Stylish Stay (Manchester) Limited | Real estate | 2015 |
| Sub-Terranea Garden Basements Limited | Construction | 2008 |
| Success Africa Ltd | Wholesale & retail | 2025 |
| Suleman Mohammad Enterprise Ltd | Wholesale & retail | 2025 |
| Summerfields Day Nursery Limited | Education | 2007 |
| Sundaymorning Limited | Extraterritorial | 2005 |
| Sundown Care Ltd | Health & social care | 2025 |
| Sunrise IT Solutions Limited | Professional & scientific | 2010 |
| Sunrise Laundry Ltd | Administrative & support | 2018 |
| Superluso Ltd | Wholesale & retail | 2023 |
| Supplement 365 Ltd | Transport & logistics | 2018 |
| Supplyur Limited | Wholesale & retail | 2017 |
| Supported Community Business (Special Needs) Limited | Administrative & support | 1998 |
| Supporting Well-Being and Nurturing Strength CIC | Education | 2016 |
| Supreme Builders Crewe Ltd | Professional & scientific | 2025 |
| Sure Retail Equipment Limited | Professional & scientific | 2003 |
| Sure-Track Europe Limited | Administrative & support | 2002 |
| Surefix EV Ltd | Construction | 2020 |
| Survivor Activewear Ltd | Manufacturing | 2022 |
| Susan Food Ltd | Hospitality | 2026 |
| Susan Hancock Limited | Health & social care | 2024 |
| Sustainable Wholesale Management Limited | Wholesale & retail | 2023 |
| Sutton Roofing Services Ltd | Construction | 2026 |
| SW Property Care+ Ltd | Transport & logistics | 2026 |
| Swanbach Grange Management Limited | Extraterritorial | 2006 |
| Swansway Group Limited | Professional & scientific | 2009 |
| Swansway TPS Blackburn Limited | Wholesale & retail | 2017 |
| Swansway TPS Carlisle Limited | Wholesale & retail | 2017 |
| Swansway TPS Manchester South Limited | Wholesale & retail | 2015 |
| Swansway TPS Preston Limited | Wholesale & retail | 2017 |
| Sweet by Magda Limited | Manufacturing | 2026 |
| Sweet Field Property Ltd | Real estate | 2021 |
| Sweeting Ltd | Wholesale & retail | 2012 |
| Swettenham Hearing Limited | Wholesale & retail | 2010 |
| Swiftrak Limited | Extraterritorial | 2016 |
| Swillzmagnum Enterprises Limited | Wholesale & retail | 2023 |
| Swirly Pearls Ltd | Hospitality | 2016 |
| SWM Management Limited | Financial services | 2018 |
| SWR Consultants Ltd | Professional & scientific | 2021 |
| Swynnerton Pictures Ltd | Information & communication | 2020 |
| Sycamore Grove Limited | Professional & scientific | 2019 |
| Sydney Market Ltd | Wholesale & retail | 2025 |
| Sykes GAS & Heating Limited | Construction | 2023 |
| Synenergy Logistics Limited | Transport & logistics | 2018 |
| Synergy Growth Solutions Limited | Professional & scientific | 2025 |
| Synergy Link Consulting Ltd | Professional & scientific | 2023 |
| Synpower Merchant Services Limited | Other services | 2016 |
| Synthesis Advisory Limited | Information & communication | 1990 |
| Syphonic Solutions Limited | Professional & scientific | 2011 |
| Sys-Con Maintenance and Support Limited | Information & communication | 1999 |
| SYZ Moves Ltd | Transport & logistics | 2025 |
| Szukala Invest Ltd | Real estate | 2020 |
| T & D Roofing (Cheshire) Limited | Construction | 2011 |
| T & M Farms LLP | | 2018 |
| T & T Property Relocations Limited | Real estate | 2024 |
| T J F Developments Limited | Construction | 2006 |
| T J Heating (Cheshire) Limited | Construction | 2019 |
| T N E Manufacturing Limited | Manufacturing | 2023 |
| T S Gardens Limited | Administrative & support | 2022 |
| T&E Nails Ltd | Other services | 2025 |
| T&L Consulting Engineers UK Limited | Construction | 2024 |
| T-T Pumps Limited | Manufacturing | 1988 |
| T.G. Howe Construction Limited | Construction | 2008 |
| T.M Hospitality Ltd | Hospitality | 2026 |
| Tablemade Hospitality Ltd | Hospitality | 2025 |
| Tackle and Baits Ltd | Wholesale & retail | 2014 |
| Tactical K9 Crewe Ltd | Administrative & support | 2012 |
| Tailored Consultant Ltd | Administrative & support | 2025 |