| DR Martin Mcconaghy Ltd | Health & social care | 2017 |
| Drews Glen Management Company Limited | Households | 2026 |
| Drink Store (Maghaberry) Ltd | Wholesale & retail | 2016 |
| Dripropertyinvestments Limited | Real estate | 2023 |
| DRT (Drivers) Limited | Administrative & support | 2017 |
| DRT (NI) Limited | Transport & logistics | 2014 |
| DRT (Office) Limited | Administrative & support | 2018 |
| Drum Property Limited | Professional & scientific | 2018 |
| Drumannon Properties Limited | Real estate | 2017 |
| Drumanphy Farms Limited | Agriculture & fishing | 2017 |
| Drumard Enterprises Ltd | Wholesale & retail | 2025 |
| Drumcree Community Trust | Education | 2000 |
| Drumgor Tavern Ltd | Hospitality | 2014 |
| Drumkirk Properties Ltd | Real estate | 2005 |
| Drumlough Churchview Meadows Management Company Ltd | Households | 2020 |
| Drummiller Farms | Agriculture & fishing | 2018 |
| Drumnabreeze Estates Ltd | Real estate | 2021 |
| Drumnacanvy Properties Limited | Real estate | 2021 |
| Drumnagoon Transport Limited | Transport & logistics | 2024 |
| DSC Architects Ltd | Professional & scientific | 2010 |
| DSR Auto Repairs Limited | Wholesale & retail | 2024 |
| Dukes Gear Ltd | Wholesale & retail | 2023 |
| Dunbarton Enterprises Ltd | Real estate | 2007 |
| Duncrue Food Processors Limited | Manufacturing | 2003 |
| Dundrod Construction Company Limited | Construction | 1974 |
| Dungannon Proteins Ltd | Manufacturing | 2000 |
| Dunn Kitchens Limited | Education | 2021 |
| Dupan N.I Limited | Manufacturing | 2022 |
| DVB Properties Ltd | Real estate | 2021 |
| DW Awning Services Limited | Construction | 2021 |
| DW Coachworks Ltd | Wholesale & retail | 2024 |
| DWS Controls Ltd | Professional & scientific | 2017 |
| Dynamic Public Affairs LLP | | 2011 |
| Dynerus Ltd | Wholesale & retail | 2019 |
| E and E Joinery LLP | | 2015 |
| E and L (Holdings) Limited | Financial services | 2019 |
| E Buchanan Limited | Agriculture & fishing | 2012 |
| E3 Enterprises Ireland Ltd | Construction | 2023 |
| E5 Properties Limited | Real estate | 2017 |
| EAC Foods Limited | Hospitality | 2019 |
| Eagle Hair CUT Ltd | Other services | 2025 |
| Eagle Quest International UK Limited | Financial services | 2021 |
| Earlswood Properties Limited | Construction | 2006 |
| Earths Secret Ltd | Wholesale & retail | 2020 |
| Eastern River Limited | Hospitality | 2015 |
| Eatao Limited | Hospitality | 2022 |
| EB Rushmere Ltd | Other services | 2025 |
| EB Spa Limited | Other services | 2022 |
| EBE Realty Ltd | Real estate | 2024 |
| Ecigs R US Ltd | Wholesale & retail | 2026 |
| Ecmr Building Company Ltd | Construction | 2014 |
| Eco-Bus Limited | Professional & scientific | 2021 |
| Ecoline Systems Limited | Wholesale & retail | 2026 |
| Ecommerceedge Ltd | Professional & scientific | 2025 |
| Econ Holdings Ltd | Financial services | 2016 |
| Ecps Holdings Limited | Financial services | 2021 |
| Edenmore Biogas Limited | Energy | 2014 |
| Edenmore Farm Produce Ltd | Agriculture & fishing | 2015 |
| Edenvilla Limited | Arts & recreation | 2000 |
| Edon Engineering UK Limited | Construction | 2023 |
| Eduard Car Wash Ltd | Wholesale & retail | 2024 |
| Edwin May,Limited | Wholesale & retail | 1955 |
| Egam Enterprises Ltd | Wholesale & retail | 1999 |
| Eggshell Cambodia | Other services | 2017 |
| Eglish Investments Limited | Construction | 2005 |
| Eglish Properties Ltd | Real estate | 2020 |
| Eijm Ltd | Extraterritorial | 2025 |
| Eire OG Craigavon Community Group Ltd | Arts & recreation | 2023 |
| EJ Kitchens & Bedrooms Ltd | Construction | 2011 |
| Ejme Limited | Wholesale & retail | 2025 |
| EL Contracts Ltd | Professional & scientific | 2016 |
| Elan Cleaning Limited | Administrative & support | 2025 |
| ELC Property Investment Ltd | Real estate | 2021 |
| Elcl NI Limited | Financial services | 2026 |
| Electrical Solutions N.I Ltd | Construction | 2025 |
| Electronic Excellence Ltd | Wholesale & retail | 2000 |
| Elegant Kitchens Ltd | Construction | 2022 |
| Elevation Coffee NI Limited | Wholesale & retail | 2020 |
| Elim Pentecostal Alliance Council. | Other services | 1921 |
| Elioros Systems Ltd | Manufacturing | 2023 |
| Elite Events Styling NI Limited | Other services | 2019 |
| Elite Groundstone Ltd | Construction | 2022 |
| Elite Houses Ltd | Real estate | 2025 |
| Elite Mortgages N.I. Limited | Financial services | 2023 |
| Elite Photo Booth Limited | Administrative & support | 2019 |
| Elizabeth Sands Beauty School Ltd | Wholesale & retail | 2017 |
| Elliott's Tradition Limited | Manufacturing | 2005 |
| Ellunia Advisory Limited | Professional & scientific | 2009 |
| Elm-Hq Ltd | Information & communication | 2026 |
| Elysium Building Contractors Ltd | Construction | 2024 |
| Ember Design Studio Limited | Professional & scientific | 2025 |
| Embracing Luxury Travel Ltd | Administrative & support | 2020 |
| Emerald Bookkeeping Ltd | Professional & scientific | 2025 |
| Emerald Energie Ltd | Professional & scientific | 2014 |
| Emerald Exterior Services NI Ltd | Construction | 2026 |
| Emerson Office Supplies Limited | Wholesale & retail | 2006 |
| EMG Planners Limited | Construction | 2016 |
| Emily's Circle CIC | Other services | 2026 |
| Emmd Couriers Ltd | Transport & logistics | 2025 |
| EMN Transcription Services Ltd | Administrative & support | 2019 |