| S.C.S.O. Limited | Construction | 2000 |
| Sailing Rallies Limited | Extraterritorial | 2015 |
| Sailing-Weather Limited | Professional & scientific | 2000 |
| Sails of Cowes Ltd | Hospitality | 2020 |
| Salt Yard Books Limited | Wholesale & retail | 2024 |
| Salty Sailing Ltd | Arts & recreation | 2018 |
| Satsuma Home Solutions Ltd | Construction | 2019 |
| Savetower Limited | Construction | 1976 |
| SB Industry Ltd | Extraterritorial | 2025 |
| Sbanalytics Ltd | Information & communication | 2022 |
| SC Fund Raising & Marketing Consultants Limited | Professional & scientific | 2010 |
| SCH Haulage Ltd | Transport & logistics | 2023 |
| Scholarly Shores Holdings Limited | Financial services | 2023 |
| Scorpion Events (UK) Limited | Administrative & support | 2025 |
| Seabreaks Ltd | Transport & logistics | 2002 |
| Seacat Services Ltd | Transport & logistics | 2010 |
| Seasafe Systems Limited | Manufacturing | 2003 |
| Seaward Marine Limited | Manufacturing | 2013 |
| Secura Operations Limited | Administrative & support | 2025 |
| Senta Consulting LLP | | 2001 |
| Senta Holdings Limited | Financial services | 1997 |
| Senta Properties LLP | | 2005 |
| Senta Quay Limited | Information & communication | 2020 |
| Senta Software Solutions Limited | Administrative & support | 1959 |
| Senta Yacht Management LLP | | 2002 |
| Servusuk Limited | Extraterritorial | 2022 |
| SG Fryer Ltd | Financial services | 2024 |
| Shamrock Villa 1861 Limited | Real estate | 2008 |
| Shipwight Interiors Ltd | Manufacturing | 2017 |
| Shoreline Carpentry IOW Ltd | Manufacturing | 2023 |
| Silver Seas Construction Services Ltd | Professional & scientific | 2019 |
| Simon Newman Software Development Limited | Information & communication | 2016 |
| Simplybungalows.Co.Uk Ltd | Real estate | 2018 |
| Sinnoh Surfaces Limited | Construction | 2025 |
| Skye Weather Ltd | Professional & scientific | 2006 |
| Sloane Property Management Limited | Real estate | 2017 |
| Smithbridge Holdings Limited | Other services | 1951 |
| Smoke N Mirrors IOW Limited | Other services | 2026 |
| Smoking Lobster Events Ltd | Hospitality | 2025 |
| Solent & Wightline Cruises (Isle of Wight) Limited | Extraterritorial | 2007 |
| Solent Carpentry and Building Ltd | Construction | 2025 |
| Solent Composite Solutions Limited | Manufacturing | 2019 |
| Solent Cruises Limited | Transport & logistics | 1998 |
| Solent Sport Assets Limited | Arts & recreation | 2025 |
| Somerton MOT Limited | Wholesale & retail | 2007 |
| Somerton Vehicle Repairs Limited | Wholesale & retail | 2019 |
| South Coast Cooling Limited | Construction | 2007 |
| South Coast Transport Ltd | Transport & logistics | 2024 |
| Southwater Aviation Ltd | Manufacturing | 2016 |
| Sowerby GAS Limited | Construction | 2023 |
| Spencer (Isle of Wight) Limited | Extraterritorial | 1993 |
| Spencer Rigging Limited | Other services | 1982 |
| SPH Defence Limited | Professional & scientific | 2025 |
| Spinlock Holdings Limited | Financial services | 2012 |
| Spinlock Limited | Manufacturing | 1968 |
| Spinlock Structures Limited | Manufacturing | 2003 |
| SPY Prints Ltd | Professional & scientific | 2019 |
| ST Wilfred Drive Management Company Limited | Households | 2018 |
| Stagegear Ltd | Wholesale & retail | 2008 |
| Stagegear Rentals Limited | Administrative & support | 2017 |
| Stagegear Sales Ltd | Wholesale & retail | 2024 |
| Stagegear Technical Solutions Limited | Construction | 2024 |
| STAMCO2025 Limited | Hospitality | 2025 |
| Staples & Green Limited | Wholesale & retail | 2012 |
| Stem Crew Ltd | Education | 2016 |
| Storeroom 2010 | Wholesale & retail | 2011 |
| Strong by Stella Ltd | Arts & recreation | 2022 |
| Style Hub IW Ltd | Other services | 2026 |
| Sugar Stack Productions Limited | Arts & recreation | 2015 |
| Sugar Stack Touring Limited | Arts & recreation | 2026 |
| Sun Hill Residents Limited | Real estate | 2015 |
| Sun Machine Ltd | Hospitality | 2024 |
| Sundry Exponents Limited | Professional & scientific | 2026 |
| Supperready C.I.C. | Hospitality | 2023 |
| Swac Properties Limited | Real estate | 2021 |
| Syncroheat Ltd | Construction | 2020 |
| T & G Childcare Ltd | Education | 2026 |
| T&I Housing Ltd | Real estate | 2023 |
| Tara Diebel Educational Psychology Limited | Education | 2024 |
| Tari Willis Associates Limited | Professional & scientific | 2010 |
| TCA Partners Ltd | Information & communication | 2024 |
| TCM IT Support Ltd | Information & communication | 2019 |
| TE Solar Services Ltd | Construction | 2023 |
| Team Emily Limited | Other services | 2009 |
| Tebs IOW Ltd | Construction | 2021 |
| Teeforetwo Ltd | Information & communication | 2026 |
| Tennyson Surveying Ltd | Professional & scientific | 2019 |
| Thai HOM Mali Ltd | Hospitality | 2024 |
| THE Cavira Group Ltd | Financial services | 2026 |
| THE Classic Boat Centre Trust | Arts & recreation | 1997 |
| THE Compass Bar Limited | Financial services | 2021 |
| THE Daisy Ring BUS CIC | Transport & logistics | 2025 |
| THE Guilded Splinter Limited | Hospitality | 2019 |
| THE GVS Method Ltd | Other services | 2025 |
| THE Happy Shell Ltd | Wholesale & retail | 2023 |
| THE Hot Box (IW) Limited | Hospitality | 2022 |
| THE House to BE Limited | Wholesale & retail | 2001 |
| THE Isle Film Company Ltd | Information & communication | 2024 |
| THE Isle of Wight Window Cleaning Company Limited | Administrative & support | 2017 |
| THE Jewellery Cabin Limited | Manufacturing | 2026 |