| Shaws Logistics Ltd | Transport & logistics | 2023 |
| Shayamma Hospitality Limited | Professional & scientific | 2024 |
| Shelt Limited | Administrative & support | 2023 |
| Shepherd M Healthcare Resources Limited | Health & social care | 2018 |
| Shepp Engineering Limited | Construction | 2022 |
| Simple Commercial Finance Limited | Financial services | 2009 |
| Simple Home Loans Limited | Professional & scientific | 2010 |
| Simplicity Web Design & Marketing Limited | Professional & scientific | 2017 |
| Sisu Retreats Ltd | Real estate | 2024 |
| SJ Property Enterprises Ltd | Real estate | 2020 |
| SJ Synergy Ltd | Water & waste | 2014 |
| SJC Properties and Investment Ltd | Real estate | 2021 |
| SKD Property Investment Ltd | Real estate | 2023 |
| Skillsync Solutions Ltd | Administrative & support | 2023 |
| Skinmetry Ltd | Professional & scientific | 2024 |
| SKN Ventures UK Ltd | Hospitality | 2023 |
| Skuld Ltd | Other services | 2023 |
| Smart Power (Northern) Limited | Construction | 2017 |
| Smart-Hellon Holdings Limited | Real estate | 2025 |
| Softpizza Limited | Hospitality | 2024 |
| SOLAR22 Limited | Administrative & support | 2011 |
| Solution Studio Limited | Information & communication | 2007 |
| Some Salt Events Co Limited | Administrative & support | 2025 |
| Sonar Developments Limited | Real estate | 2012 |
| Sonar Properties Limited | Real estate | 2018 |
| Sonic Site Works Limited | Construction | 2019 |
| Sonreep Limited | Financial services | 2025 |
| South Orbital Management Limited | Real estate | 1994 |
| South Sea Care Ltd | Health & social care | 2025 |
| South Sea Property Ltd | Real estate | 2024 |
| Sowden Digital Ltd | Information & communication | 2012 |
| Speczen Ltd | Information & communication | 2018 |
| Speedybox Ltd | Transport & logistics | 2024 |
| Spiders From Mars Limited | Other services | 2012 |
| SPL Livingstone Ltd | Hospitality | 2024 |
| SPV BC1 Limited | Construction | 2025 |
| SPV BC2 Limited | Construction | 2025 |
| SPV BC3 Limited | Construction | 2025 |
| SPV BC4 Limited | Construction | 2025 |
| SPV BC5 Limited | Construction | 2025 |
| SQ Security & Electrical Ltd | Manufacturing | 2026 |
| Squideo Limited | Information & communication | 2015 |
| SS Properties (Yorkshire) Limited | Construction | 2022 |
| Stage 3 Catering Limited | Hospitality | 2015 |
| Stakeman Computers (UK) Ltd | Information & communication | 2007 |
| Stanley Restaurant Ltd | Hospitality | 2009 |
| Starlife Elite Limited | Administrative & support | 2023 |
| Station Garage (Little Weighton) Limited | Wholesale & retail | 2003 |
| Steel MET Building Products Limited | Wholesale & retail | 2003 |
| Stenergy Electrical Contractors Ltd | Construction | 2022 |
| Stephen Mathuthu Healthcare Resources Limited | Health & social care | 2017 |
| Steve Robins Golf Limited | Arts & recreation | 2025 |
| Steve's Cycles Limited | Wholesale & retail | 2022 |
| Stevenson Process Technology Ltd | Mining & quarrying | 2016 |
| Stone's Mount Flat Management Company Limited | Real estate | 1976 |
| Storage Containers Cottingham Limited | Transport & logistics | 2019 |
| Storey Felt Roofing Limited | Construction | 1999 |
| Strada Homes Limited | Households | 2007 |
| Strategic Infrastructure Solutions Limited | Professional & scientific | 2022 |
| Streamline Business Ltd | Administrative & support | 2019 |
| Substruct Engineering Limited | Professional & scientific | 2022 |
| Summers Drive Management Company Limited | Households | 2018 |
| Sussex Retail and Wedding Catering Limited | Hospitality | 2014 |
| Sutton Homes Ltd | Construction | 1986 |
| Sutton Leisure Limited | Professional & scientific | 1985 |
| Sweet Clean Ltd | Administrative & support | 2025 |
| Swift Acquisitions Limited | Professional & scientific | 2012 |
| Swift Leisure Group Limited | Extraterritorial | 2012 |
| Swift Leisure Holdings Limited | Professional & scientific | 2017 |
| Sydney Management Limited | Arts & recreation | 2016 |
| Synergy Skin & Spa Ltd | Other services | 2025 |
| Synergy Skin Clinic Limited | Health & social care | 2024 |
| T & a Services (Hull) Limited | Professional & scientific | 2021 |
| Taiola Global Ltd | Health & social care | 2023 |
| Tangerine Creative Marketing Limited | Manufacturing | 2014 |
| Tatty Little Cat Ltd | Wholesale & retail | 2024 |
| Taylor & Stafford Ltd | Construction | 2018 |
| Taylor Entertainment Limited | Arts & recreation | 2024 |
| Taylor IT Consultancy Limited | Information & communication | 2016 |
| TBR Fire Door Installations Ltd | Construction | 2026 |
| TDM Fire Door Specialists Ltd | Construction | 2026 |
| Teamakta Ltd | Arts & recreation | 2023 |
| Tegrimed Ltd | Professional & scientific | 2025 |
| Terratech Limited | Manufacturing | 2010 |
| THE Alan Plater Estate Ltd | Arts & recreation | 2018 |
| THE Apple L Ltd | Hospitality | 2026 |
| THE Barbell Cartel Limited | Wholesale & retail | 2024 |
| THE Bathroom Sanctuary Ltd | Wholesale & retail | 2014 |
| THE Battlements Estate Limited | Professional & scientific | 2002 |
| THE Consortium Academy Trust | Public administration | 2011 |
| THE Cosmetic Consultancy Ltd | Professional & scientific | 2022 |
| THE Cottingham Memorial Club Trust, Limited | Other services | 1923 |
| THE County House Group Limited | Professional & scientific | 1995 |
| THE Dance and Entertainments Company Limited | Professional & scientific | 2003 |
| THE Edge Elite Performance Training Limited | Arts & recreation | 2013 |
| THE Ethical Fostering Service Limited | Health & social care | 2017 |
| THE Garth 1965 Limited | Extraterritorial | 2013 |
| THE Good Seed Counselling Ltd | Health & social care | 2025 |
| THE Hall PLH Limited | Health & social care | 2025 |
| THE Hall Thornton Dale Limited | Health & social care | 2018 |