| CW12 Studios Ltd | Other services | 2020 |
| CWC Cheshire Wraps Ltd | Wholesale & retail | 2025 |
| Cwikops Ltd | Information & communication | 2019 |
| Cycle Centre Congleton Limited | Wholesale & retail | 2004 |
| Cyclestore Limited | Extraterritorial | 2004 |
| D & I H Developments Limited | Real estate | 2014 |
| D & T Painting Ltd | Construction | 2025 |
| D Abrahamse Services Limited | Professional & scientific | 2008 |
| D B Fabrications (Congleton) Limited | Other services | 2025 |
| D Belfield Construction Ltd | Construction | 2024 |
| D Goodwin Projects Limited | Professional & scientific | 2025 |
| D H Townley Heating & GAS Solutions LLP | | 2011 |
| D M Learning Limited | Education | 2023 |
| D M Tiling (Cheshire) Ltd | Construction | 2018 |
| D Manfield Installations Limited | Construction | 2022 |
| D P Sportswear Limited | Wholesale & retail | 1995 |
| D Stanway Electrical Ltd | Construction | 2004 |
| D&B Upholstery Ltd | Manufacturing | 2020 |
| D. Howell Services Ltd | Professional & scientific | 2006 |
| D.R Health and Safety Solutions Limited | Administrative & support | 2012 |
| D.Speed Construction Ltd | Construction | 2016 |
| D4S Holdco Ltd | Financial services | 2026 |
| DA Mortgages Ltd | Financial services | 2023 |
| DAE Brickworks Ltd | Construction | 2019 |
| Daintry Hall Day Nursery & Pre-School Limited | Health & social care | 2025 |
| Daintry Hall Day Nursery Limited | Health & social care | 2008 |
| Dalek Limited | Wholesale & retail | 2025 |
| DAN Oliver Accountancy Services Limited | Professional & scientific | 2014 |
| DAN Procter Logistics Limited | Transport & logistics | 2018 |
| Danda Management Company Limited | Professional & scientific | 2012 |
| Danderhall Management Limited | Professional & scientific | 2013 |
| Dane Ridge Joinery & Construction Ltd | Construction | 2009 |
| Dane Storage Developments Limited | Construction | 2015 |
| Dane Storage Holdings Limited | Financial services | 2015 |
| Danebank Court Limited | Administrative & support | 1975 |
| Danebank View Limited | Households | 1973 |
| Danebrook Consulting Ltd | Administrative & support | 2017 |
| Danechem Limited | Professional & scientific | 2025 |
| Danesbury Estates and Properties Limited | Financial services | 1991 |
| Daneside Community Theatre Trust Limited | Arts & recreation | 1978 |
| Daneside Solutions Limited | Wholesale & retail | 2023 |
| Daniel Bennett Flooring Ltd | Construction | 2025 |
| Daniel Smith Electrical Services Limited | Construction | 2017 |
| Daniel Taylor Builder & Architectural Woodworker Limited | Construction | 1974 |
| Danva Interiors Ltd | Construction | 2007 |
| Darnell Property Developments Limited | Construction | 2014 |
| Dartan Limited | Professional & scientific | 2012 |
| Darton Property Holdings Limited | Financial services | 2024 |
| Dash Companies Limited | Information & communication | 2015 |
| Datanorth Limited | Information & communication | 1982 |
| Datasolace Ltd | Information & communication | 2024 |
| Datastor Systems Limited | Manufacturing | 1978 |
| Davenport Stud Limited | Administrative & support | 2010 |
| Davenports Menswear Ltd | Wholesale & retail | 2022 |
| David Haynes Ltd | Construction | 2005 |
| David J Mclellan Limited | Transport & logistics | 2011 |
| David Tindall Associates Ltd | Real estate | 2014 |
| Dawes Security Limited | Administrative & support | 2005 |
| DC Assist Limited | Administrative & support | 2015 |
| DC Developments (UK) Limited | Construction | 2006 |
| DC Landscapes NW Ltd | Administrative & support | 2023 |
| DC Tuning Limited | Wholesale & retail | 2020 |
| DCA Property Management Ltd | Households | 2022 |
| DCS Business Consulting Ltd | Information & communication | 2024 |
| DDT Management Ltd | Real estate | 2018 |
| De-Vaal Projects Ltd | Construction | 2023 |
| Deaville&Co Ltd | Administrative & support | 2009 |
| Deborah Lees Art Ltd | Arts & recreation | 2008 |
| Deeker Limited | Professional & scientific | 2013 |
| Deep Blue Holding Limited | Real estate | 2022 |
| Deepdale Investments Ltd | Administrative & support | 2014 |
| Deetec Engineering Ltd | Construction | 2017 |
| Defendit Limited | Wholesale & retail | 2026 |
| Define Aesthetics (Wilmslow) Ltd | Other services | 2019 |
| Delegate 2 Accelerate Ltd | Administrative & support | 2020 |
| Delta Europe Limited | Manufacturing | 1989 |
| Delymat Limited | Professional & scientific | 2012 |
| Denby Leisure Ltd | Wholesale & retail | 2024 |
| Denia Property Limited | Professional & scientific | 2009 |
| Desi Divas Ltd | Administrative & support | 2007 |
| Design Duck Limited | Professional & scientific | 2023 |
| Designs on U (Trading AS Diamond Engravers) Limited | Manufacturing | 2005 |
| Devanet (UK) Limited | Manufacturing | 2014 |
| Dewrang Ltd | Professional & scientific | 2013 |
| DF Infosec Limited | Information & communication | 2022 |
| Dhja Limited | Financial services | 2022 |
| Diamond Scissors Ltd | Other services | 2024 |
| Didimo Ltd | Information & communication | 2010 |
| Didsford Services Limited | Real estate | 2023 |
| Diggory Investments Ltd | Financial services | 2016 |
| Digital and Brand Ltd | Information & communication | 2024 |
| Digitech Gaming Limited | Professional & scientific | 2020 |
| Dime Transport Limited | Transport & logistics | 2009 |
| Direct Wealth Group Ltd | Financial services | 2022 |
| Direct Wealth Management Limited | Financial services | 2016 |
| Distilled Events Ltd | Administrative & support | 2019 |
| Dixon Logistics Management Ltd | Construction | 2015 |
| DJH Wealth Management Limited | Financial services | 2025 |
| DJH Windows and Doors Ltd | Construction | 2023 |
| DK NC Programming Services Limited | Manufacturing | 2012 |