| Dlmi Rental Properties Limited | Real estate | 2022 |
| Dlmi UK Limited | Real estate | 2016 |
| DMI Comms Ltd | Information & communication | 2021 |
| Dobford Grange Residents Association Limited | Professional & scientific | 2002 |
| Domain House Limited | Information & communication | 2013 |
| Domain Property Management Limited | Real estate | 2022 |
| Done N Dusted (Cheshire) Limited | Administrative & support | 2009 |
| Donington Grove Management Limited | Households | 2025 |
| Donmar Ltd | Administrative & support | 2026 |
| DOORS4SECURITY Limited | Wholesale & retail | 2000 |
| Dorcas Languages Ltd | Education | 2014 |
| Double Lucky 2026 Ltd | Hospitality | 2026 |
| Douglas Hlcm Group Limited | Construction | 2025 |
| Doxley Limited | Administrative & support | 2011 |
| DPR Controls Ltd | Administrative & support | 2011 |
| Drago Property Limited | Professional & scientific | 2010 |
| Draussen Limited | Extraterritorial | 2022 |
| Drayer Limited | Real estate | 2014 |
| Drinton Limited | Professional & scientific | 2011 |
| Drip Hacks International Ltd | Wholesale & retail | 2025 |
| Drivewiser Ltd | Education | 2023 |
| Drukwall Ltd | Construction | 2025 |
| DRY Water Design Limited | Real estate | 1994 |
| DS Ceilings and Partitions Limited | Construction | 2015 |
| Ds&B Consulting Ltd | Professional & scientific | 2024 |
| Dsdr Consultancy Ltd | Information & communication | 2013 |
| DTA (Properties) Ltd | Real estate | 2021 |
| Dtec Heating Solutions Ltd | Construction | 2025 |
| DUB 23 Investments Limited | Real estate | 2026 |
| Dumplingandting Ltd | Hospitality | 2023 |
| Dungal Property Ltd | Real estate | 2024 |
| Dunstan & Wragg (Castings) Limited | Manufacturing | 2011 |
| Durington Limited | Professional & scientific | 2012 |
| DV8 Cheshire Ltd | Hospitality | 2019 |
| DV8 Congleton (Cheshire) Ltd | Hospitality | 2019 |
| DV8 Sandbach (Cheshire) Ltd | Hospitality | 2019 |
| DWQ Enterprise Limited | Financial services | 2007 |
| Dyagonal Ltd | Real estate | 2021 |
| Dynamic Electrical and Security Solutions Ltd | Administrative & support | 2021 |
| Dynasurf(U.K.)Limited | Manufacturing | 1971 |
| E Beech Joinery Ltd | Manufacturing | 2011 |
| E Brainee Education Limited | Information & communication | 2023 |
| E G H Corp Limited | Wholesale & retail | 2021 |
| E L Lilley Limited | Arts & recreation | 2019 |
| E R Powell & SON Ltd | Administrative & support | 2009 |
| E Rhodes Joinery Limited | Construction | 2004 |
| E-Zu Solutions Limited | Information & communication | 2002 |
| Earles Car & Commercial Repairs Limited | Wholesale & retail | 2016 |
| Earth Drop Services Limited | Wholesale & retail | 2025 |
| East 360 Restaurant Ltd | Hospitality | 2024 |
| East Cheshire Chamber of Commerce & Enterprise Limited | Administrative & support | 1993 |
| East Cheshire Heating Limited | Construction | 2025 |
| East Cheshire Training Limited | Other services | 2019 |
| Eastgate IT Limited | Information & communication | 2011 |
| EASY2REACH.CO.UK Limited | Wholesale & retail | 2009 |
| Easyfit Heat Pumps Ltd | Construction | 2025 |
| EBL Ltd | Information & communication | 2025 |
| Ecargio Ltd | Information & communication | 2013 |
| ECC UK West Limited | Professional & scientific | 2015 |
| Eclipse Advisory Services Limited | Professional & scientific | 2026 |
| Eco Excellence Ltd | Construction | 2024 |
| Ecoairsource Ltd | Professional & scientific | 2021 |
| Ecurie Royal Oak Motor Club Limited | Arts & recreation | 1979 |
| ED Creative Ltd | Professional & scientific | 2015 |
| Ederoyd Mount Limited | Professional & scientific | 2013 |
| Edge Distillers Limited | Manufacturing | 2025 |
| Edge Drama Academy Limited | Arts & recreation | 2021 |
| Edit Design Consultancy Limited | Professional & scientific | 2009 |
| Edit Veils Limited | Manufacturing | 2023 |
| EDM - Havin' IT Large Ltd | Information & communication | 2021 |
| EES Commercial Ltd | Real estate | 2026 |
| EES Housing Ltd | Real estate | 2023 |
| Effective Farming Solutions Ltd | Manufacturing | 2025 |
| Efordia Limited | Wholesale & retail | 2020 |
| Egerton-Brooks Family Butchers Limited | Wholesale & retail | 2010 |
| EGG & Onion Limited | Health & social care | 2022 |
| Egglestone Rentals Limited | Real estate | 2024 |
| Ejane Ltd | Administrative & support | 2019 |
| EJS Eventing LLP | | 2010 |
| Ekin Engineering Limited | Hospitality | 2020 |
| Ekin Engineering Sales Ltd | Wholesale & retail | 2022 |
| EL Paco Ltd | Hospitality | 2025 |
| Elaine Bromley Counselling Services Ltd | Health & social care | 2024 |
| Eland Trans Ltd | Transport & logistics | 2025 |
| Elderwood Supplies Limited | Wholesale & retail | 2020 |
| Electric Picture House Artists Co-Operative Ltd | Arts & recreation | 2012 |
| Electrical Installation Supplies Limited | Wholesale & retail | 2008 |
| Electrician Cheshire Ltd | Construction | 2020 |
| Elegante Property Limited | Professional & scientific | 2009 |
| Elekt Performance Ltd | Health & social care | 2026 |
| Elevate Accounting Solutions Limited | Professional & scientific | 2018 |
| Elevate Orthotics Ltd | Wholesale & retail | 2026 |
| Elevelle Ltd | Information & communication | 2025 |
| Elfram Limited | Professional & scientific | 2012 |
| Elite Site Services Ltd | Professional & scientific | 2022 |
| Elite Vale Ltd | Wholesale & retail | 2025 |
| ELL Burto Limited | Manufacturing | 2018 |
| Ellburto-Engineering Ltd | Manufacturing | 2026 |
| Elliot KAY Education Ltd | Education | 2025 |
| Elliot KAY Limited | Other services | 2021 |