| Skydream Property Co. Limited | Extraterritorial | 1984 |
| Slam Electrical Services Ltd | Construction | 2025 |
| Slav Transports Ltd | Transport & logistics | 2024 |
| Slaw Ltd | Transport & logistics | 2016 |
| SLB Supplies Limited | Wholesale & retail | 2002 |
| Slik Motorcycles Ltd | Wholesale & retail | 2020 |
| Slipstop GB Ltd | Administrative & support | 2019 |
| Slitherin Reptiles Limited | Wholesale & retail | 2014 |
| SLM Delivery Ltd | Transport & logistics | 2020 |
| Slow Jazz Clothing Ltd | Wholesale & retail | 2021 |
| Small SEO Limited | Information & communication | 2017 |
| Smalley Pressings Limited | Manufacturing | 2006 |
| Smallwood Properties Limited | Administrative & support | 1992 |
| Smart Accountants (Small Business Centre ) Limited | Professional & scientific | 2016 |
| Smart Outsourcing Solutions Limited | Extraterritorial | 2014 |
| Smart Properties (Derby) Ltd | Real estate | 2018 |
| Smart Properties (Warner) Ltd | Households | 2021 |
| Smart Technology Solutions Limited | Information & communication | 1997 |
| Smart Wearable.Ai Ltd | Wholesale & retail | 2025 |
| Smartlet Leicester Limited | Households | 2023 |
| Smartrack Limited | Professional & scientific | 2005 |
| Smile Serenity Ltd | Health & social care | 2018 |
| Smird Systems Limited | Information & communication | 2013 |
| Smiths Construction (Midlands) Ltd | Manufacturing | 2017 |
| Smiths Prestige Properties Ltd | Real estate | 2018 |
| SMP (Ashby) Limited | Administrative & support | 2014 |
| Smpt Ltd | Arts & recreation | 2024 |
| SN & S Consultancy Ltd | Professional & scientific | 2025 |
| Social Husky Marketing Ltd | Professional & scientific | 2024 |
| Software 4 ALL Ltd | Information & communication | 2004 |
| Software Brokers Ltd | Wholesale & retail | 2022 |
| Software Micro Ltd | Wholesale & retail | 2011 |
| Solace Technologies Group Ltd | Administrative & support | 2016 |
| Sold Consultancy Ltd | Wholesale & retail | 2026 |
| Solo Studio Ltd | Wholesale & retail | 2021 |
| Solutions 2 (Contract Cleaning) Limited | Administrative & support | 2010 |
| Sophisticated Legs Ltd | Manufacturing | 2012 |
| Sorry in Advance Ltd | Agriculture & fishing | 2024 |
| Sourcing Allies Great Britain Limited | Wholesale & retail | 2019 |
| South PIT Supplies Ltd | Wholesale & retail | 2020 |
| Sparkling Clin Ltd | Administrative & support | 2026 |
| Sparkly Touch Ltd | Administrative & support | 2026 |
| SPB Property Management Limited | Extraterritorial | 2013 |
| Special Operations Academy Ltd | Education | 2020 |
| Specialist Consultancy Services LLP | | 2008 |
| Speedy Waste Clearances Ltd | Water & waste | 2023 |
| Spence Education Consulting Limited | Education | 2024 |
| Spinney View Shepherds Huts Ltd | Hospitality | 2021 |
| Spmc Consultancy Ltd | Wholesale & retail | 2022 |
| Spmc Electrical Services Ltd | Manufacturing | 2024 |
| Spmc Race Engines Ltd | Manufacturing | 2024 |
| Sports and Courts Line Marking Ltd | Construction | 2012 |
| Sports and Courts Maintenance Limited | Administrative & support | 2018 |
| Spot on Electrical (Midlands) Ltd | Construction | 2022 |
| Springboard Training Ltd | Education | 2019 |
| Springfield Training Consultants Ltd | Professional & scientific | 2015 |
| Springfields (UK) Limited | Professional & scientific | 2003 |
| Springwood Vale | Financial services | 2026 |
| SQR Nest Ltd | Real estate | 2025 |
| Squires Bridge Homes Limited | Administrative & support | 1996 |
| Squires Bridge Limited | Construction | 1986 |
| SR Beauty Instruments Ltd | Wholesale & retail | 2022 |
| SS Metalworks Limited | Manufacturing | 2023 |
| SSS Car Valeting Ltd | Wholesale & retail | 2023 |
| ST Josephs Tea Room Ltd | Hospitality | 2015 |
| Staged 4 More Limited | Construction | 2018 |
| Stairlift Medics Limited | Professional & scientific | 2022 |
| Stan Bespoke Suits Ltd | Manufacturing | 2026 |
| Standforce Solutions Limited | Administrative & support | 2023 |
| Standout Design & Marketing Ltd | Professional & scientific | 2023 |
| Star Barber 2 Ltd | Other services | 2024 |
| Star Barber Coalville Ltd | Other services | 2019 |
| Star City Cleaning Services Ltd | Administrative & support | 2020 |
| Star Food Coalville Ltd | Hospitality | 2024 |
| Starbeck Educational Resources Ltd | Education | 2020 |
| Starline Ball Valves Limited | Wholesale & retail | 2001 |
| Stars Mobile Limited | Other services | 2019 |
| Static Electrical Contractors Ltd | Construction | 2020 |
| Stealth Black Belt Academy LLP | | 2015 |
| Stealth Family Limited | Arts & recreation | 2025 |
| Stealthmovements Telematics Ltd | Administrative & support | 2025 |
| Stempelek Ltd | Professional & scientific | 2015 |
| Sterimax Global Limited | Wholesale & retail | 2021 |
| Steve Boam Builders & Joiners Ltd | Construction | 2002 |
| Stilgoe Fabrication Ltd | Manufacturing | 2026 |
| Stinsons & Family Ltd | Other services | 2023 |
| Stinsons Ltd | Other services | 2023 |
| Stinsons of Whitwick IFD Ltd. | Other services | 2014 |
| STM Traffic Limited | Administrative & support | 2014 |
| Stoneyfield Management Limited | Households | 1991 |
| Storabox Ltd | Transport & logistics | 2023 |
| Store 84 Ltd | Wholesale & retail | 2024 |
| Storm Group Roofing Limited | Construction | 2026 |
| Strandz Ltd | Other services | 2004 |
| Strange Property Company | Construction | 1960 |
| Structural Innovation Design Ltd | Professional & scientific | 2024 |
| Stuarts E.G. Limited | Financial services | 2006 |
| Stuartwesley Ltd | Hospitality | 2022 |
| Student Beehive (Leicester) Ltd | Real estate | 2019 |
| Student Beehive FR Ltd | Real estate | 2025 |