| Ruff Idea Sales & Management Ltd | Administrative & support | 2017 |
| Rugbytots Charnwood & North West Leicestershire LLP | | 2019 |
| Runco Limited | Hospitality | 2025 |
| Ruskin Cain Financial Services Limited | Real estate | 2007 |
| Russell's Garden Buildings Ltd | Construction | 2022 |
| RW Construction Training Ltd | Education | 2017 |
| RWC Ltd | Financial services | 2017 |
| RWC Vans Direct Limited | Wholesale & retail | 2025 |
| Ryder Imports Limited | Wholesale & retail | 1991 |
| Rêvera London Limited | Manufacturing | 2025 |
| S & B Tyres Limited | Other services | 2002 |
| S & J (EM) Ltd | Transport & logistics | 2022 |
| S a Gamble Ltd | Construction | 2019 |
| S D Hill Plumbing & Heating Ltd | Other services | 2011 |
| S J Pendleton Limited | Professional & scientific | 2025 |
| S S Moga Limited | Transport & logistics | 2025 |
| S.J.Chisholm Limited | Financial services | 2001 |
| S17 Photography Ltd | Professional & scientific | 2022 |
| S21 Ventures Limited | Professional & scientific | 2024 |
| Sacred Lodgings Ltd | Health & social care | 2023 |
| Safeguard 24/7 Ltd | Administrative & support | 2018 |
| Safeguard FM Ltd | Administrative & support | 2024 |
| Safeguard Investment Group Ltd | Real estate | 2024 |
| Safety in Science Ltd | Professional & scientific | 2025 |
| Sag-Tek Limited | Manufacturing | 2024 |
| Sako Barber Shop Limited | Other services | 2022 |
| Samosa Station Ltd | Hospitality | 2024 |
| Sanderson Ward Ltd | Financial services | 2023 |
| Sandhu Transport Leics Ltd | Transport & logistics | 2024 |
| Sangopn Care Ltd | Health & social care | 2024 |
| Sangozburg Limited | Health & social care | 2014 |
| Santù Music Ltd | Information & communication | 2024 |
| Sapphire Electronic Security Ltd | Other services | 2018 |
| Saracens Security Limited | Other services | 2006 |
| Sarah Whinkless PV Limited | Professional & scientific | 2015 |
| Sawski Ltd | Transport & logistics | 2024 |
| SC IT Solutions Ltd | Information & communication | 2010 |
| Schluter Systems Limited | Manufacturing | 1993 |
| Scicomp Ltd | Information & communication | 2025 |
| Scoble Innovation Ltd | Professional & scientific | 2026 |
| Scopecell Limited | Construction | 1980 |
| Scott Lettings and Real Estate Ltd | Real estate | 2024 |
| SD Knitting Ltd | Manufacturing | 2012 |
| SDA Transport Ltd | Transport & logistics | 2021 |
| Seal Elastics Co. Holdings Ltd | Financial services | 2024 |
| Second 2 None (Valeting) Ltd | Administrative & support | 2006 |
| Second 2 None Clothing and Footwear Ltd | Wholesale & retail | 2021 |
| Secure Home Buy Ltd | Real estate | 2016 |
| Secure Payment Technologies Limited | Wholesale & retail | 2024 |
| Secure Payment Transactions Limited | Information & communication | 2015 |
| Security Alarms and Cash Solutions Ltd | Administrative & support | 2020 |
| SEJ Restaurants Group Ltd | Hospitality | 2024 |
| SEL Stewart Estates Ltd | Households | 2024 |
| Selective Autos Ltd | Wholesale & retail | 2019 |
| SEM Contractors Ltd | Construction | 2019 |
| Sensible Counselling Ltd | Health & social care | 2025 |
| Settle Easy Ltd | Administrative & support | 2025 |
| Sewbox Ltd | Wholesale & retail | 2025 |
| Shadowline Hub UK Limited | Wholesale & retail | 2018 |
| Shane and Leighann Informatics Services Ltd | Information & communication | 2025 |
| Sharpe Maintenance Services Limited | Manufacturing | 2006 |
| Sharpes Garden Services Limited | Administrative & support | 1998 |
| Sharpe’S Electrical Ltd | Construction | 2020 |
| Shaw Thing Productions Limited | Arts & recreation | 2016 |
| Shawfield Logistics Ltd | Transport & logistics | 2014 |
| SHC Solutions Ltd | Wholesale & retail | 2019 |
| SHE CAN Water Ltd | Manufacturing | 2025 |
| Shears Brothers (Transport) Ltd. | Transport & logistics | 1977 |
| Shearsby Valley Lakes Ltd | Agriculture & fishing | 2019 |
| Shearsby Valley Tackle Limited | Agriculture & fishing | 2017 |
| Shephard Services Ltd | Wholesale & retail | 2023 |
| Shepherd and White Limited | Real estate | 2009 |
| Shipon Bar Limited | Hospitality | 2026 |
| Shires Event Hire Limited | Hospitality | 2015 |
| Shooterz Leisure Limited | Hospitality | 2024 |
| Shore Travel Group Limited | Administrative & support | 2024 |
| Shredz Fitness Centre Ltd | Other services | 2015 |
| Shrouded OWL Ltd | Professional & scientific | 2023 |
| Sibson & Shaw Ltd | Real estate | 2021 |
| Silvan Tree Specialists Limited | Agriculture & fishing | 2016 |
| Simes (Fasteners) Limited | Wholesale & retail | 1977 |
| Simla Accessories Ltd | Wholesale & retail | 2025 |
| Simon Coope Karate School Ltd | Arts & recreation | 2024 |
| Simon Hewitt Joinery Limited | Construction | 2022 |
| Simulaids Ltd | Wholesale & retail | 2000 |
| Sirianuera Ltd | Education | 2025 |
| Sit-Stand World Limited | Financial services | 2020 |
| Sivyer Logistics Limited | Administrative & support | 2009 |
| Sivyer Recycling Limited | Water & waste | 2014 |
| SIX Hills Pallets Ltd | Manufacturing | 2002 |
| SIX to TEN Superstore Ltd | Wholesale & retail | 2020 |
| Sixty Seven Properties Limited | Real estate | 2022 |
| SJB Management Services (Leicester) Limited | Real estate | 2005 |
| Sjmdirect Ltd | Transport & logistics | 2015 |
| SJT2024 Ltd | Wholesale & retail | 2024 |
| SK Consult& Invent Properties Ltd | Hospitality | 2018 |
| Sketch Design & Planning Studio Limited | Professional & scientific | 2021 |
| SKG Commerce Ltd | Wholesale & retail | 2024 |
| Skinetica Ltd | Arts & recreation | 2019 |
| SKO Properties Ltd | Real estate | 2025 |