| Easy PAY Flooring Limited | Wholesale & retail | 2019 |
| EASY123 Solutions Limited | Information & communication | 2011 |
| Easyfare Limited | Wholesale & retail | 1982 |
| Eaton Cost Management Ltd | Professional & scientific | 2020 |
| Eaves Hall Cottages Limited | Hospitality | 2013 |
| Eaves Hall Hotel Limited | Hospitality | 2011 |
| Eaves Hall Hounds Limited | Other services | 2021 |
| Echomike Ltd | Information & communication | 2026 |
| Eco Assessors and Survey Inspections Ltd | Professional & scientific | 2024 |
| Eco Compliance NW Ltd | Information & communication | 2025 |
| Eco Giants Funding Ltd | Administrative & support | 2024 |
| Eco Sure UK Limited | Administrative & support | 2023 |
| Eco Titan Ltd | Construction | 2024 |
| Eco Trade Giants Ltd | Wholesale & retail | 2022 |
| Eden Insurance Services Limited | Financial services | 2000 |
| Edible Print Supplies Ltd | Wholesale & retail | 2015 |
| Edisford Bridge Limited | Hospitality | 2003 |
| Edisford Investments Limited | Financial services | 2025 |
| Edisford Joinery and Construction Limited | Construction | 2008 |
| Edisford Road Management Company Limited | Real estate | 2016 |
| Edison Ashworth Ltd | Manufacturing | 2025 |
| EDR Financial Management Limited | Professional & scientific | 2011 |
| Edward Englander Design Partnership Limited | Professional & scientific | 1987 |
| Edwards Podiatry Ltd | Health & social care | 2015 |
| Efficient Energy Services Ltd | Construction | 2020 |
| Efficient Energy Solutions Ltd | Professional & scientific | 2022 |
| Egaw Limited | Extraterritorial | 2011 |
| Eglin Construction Ltd | Construction | 2022 |
| EJL Property Services Ltd | Real estate | 2025 |
| EJP Fleet Advisory Ltd | Transport & logistics | 2026 |
| EJP Gloves Ltd | Wholesale & retail | 2023 |
| Elan Precision Group Ltd | Financial services | 2020 |
| Elan Precision Limited | Manufacturing | 2005 |
| Electric Facilities (Burnley) Limited | Real estate | 1939 |
| Electrifi Limited | Information & communication | 2021 |
| Eleo Talent Solutions Ltd | Health & social care | 2020 |
| Elevate Workshops Limited | Education | 2022 |
| Elisa Belle Ltd | Wholesale & retail | 2019 |
| Elite Balustrade Systems Ltd | Manufacturing | 2018 |
| Elite Netball Ltd | Education | 2022 |
| Elite SC Limited | Arts & recreation | 2006 |
| Elizabeth Hall Country Houses Bureau Limited | Real estate | 2008 |
| Ellez Limited | Other services | 2022 |
| Ellithorn Financial Planning Ltd | Financial services | 2025 |
| Elms House Ltd | Health & social care | 2016 |
| EM Garage Services Limited | Wholesale & retail | 2018 |
| EM3 Solutions Ltd | Professional & scientific | 2019 |
| Emergent Limited | Information & communication | 2012 |
| EMG and HEN Limited | Real estate | 2025 |
| EMG Lettings Limited | Real estate | 2020 |
| EMG Surveying Ltd | Professional & scientific | 2013 |
| EML Clothing Ltd | Wholesale & retail | 2026 |
| Emporia (Kirkby Lonsdale) Limited | Hospitality | 2010 |
| Emporia Limited | Hospitality | 2002 |
| Emtac Holdings Ltd | Administrative & support | 2024 |
| Emtac Ltd | Administrative & support | 2018 |
| Emtac Services Limited | Administrative & support | 2019 |
| Encore Apartments Ltd | Hospitality | 2018 |
| Engineering Dynamics Electrical & Mechanical Ltd | Construction | 2025 |
| Enjoy Wellness Centre Limited | Arts & recreation | 2014 |
| Ensample Limited | Extraterritorial | 2014 |
| Enterprise UAV Training Academy Ltd | Education | 2025 |
| Entry Expert Ltd. | Information & communication | 2007 |
| Envirosite UK Ltd | Administrative & support | 2026 |
| ENX Ltd | Real estate | 2018 |
| Epauk Limited | Arts & recreation | 2021 |
| Epiiic Media Ltd | Information & communication | 2025 |
| Epitrade Ltd | Information & communication | 2018 |
| Equib Limited | Professional & scientific | 2002 |
| Eric Thomas Footwear Development Limited | Wholesale & retail | 2005 |
| Erids Limited | Professional & scientific | 2013 |
| Escobar Limited | Wholesale & retail | 2014 |
| Estate and Property Limited | Financial services | 2007 |
| Ethic Apparel Ltd | Wholesale & retail | 2023 |
| Euroadapt Ltd | Extraterritorial | 2003 |
| Eval TEC Ltd | Wholesale & retail | 2024 |
| EVC Mobility Ltd | Wholesale & retail | 2026 |
| Even Flow Ventures Ltd | Hospitality | 2019 |
| Events by Toms Table Ltd | Hospitality | 2024 |
| Evergreen Forest School Ltd | Health & social care | 2025 |
| Everitt Consulting Limited | Information & communication | 2008 |
| Every Step Counts Send Services Ltd | Education | 2025 |
| Everyone Communicates Ltd | Education | 2023 |
| Evoke Support Limited | Health & social care | 2024 |
| EVS Fleet Maintenance Ltd | Wholesale & retail | 2025 |
| EVS Group Asset Management Ltd | Wholesale & retail | 2025 |
| EVS Power Ltd | Wholesale & retail | 2025 |
| EVS Strategic Holdings Ltd | Extraterritorial | 2025 |
| Excel Analysis Services Ltd | Information & communication | 2012 |
| Exlx Limited | Arts & recreation | 2021 |
| Experience Consultancy Ltd | Administrative & support | 2023 |
| EYE Candy Digital Limited | Information & communication | 2015 |
| Ezyclean NW Ltd | Administrative & support | 2023 |
| Ezyflow Ltd | Manufacturing | 2010 |
| F&M Care Holdings Ltd | Health & social care | 2022 |
| F.G. Rowland Limited | Wholesale & retail | 1984 |
| F.P. Cherry & Sons Limited | Real estate | 1985 |
| F1 Holdings Ltd | Financial services | 2016 |
| Fair Property Solutions Ltd | Construction | 2022 |
| Fairoak Engineering Limited | Professional & scientific | 2021 |