| Decron Safety Netting Ltd | Construction | 2014 |
| DEE BEE (Performance Plastics) Limited | Manufacturing | 2008 |
| Deep Beauty Ltd | Other services | 2006 |
| Deli to Go NW Limited | Hospitality | 2019 |
| Deltaview Homes Limited | Real estate | 2000 |
| Deluxe Home Designs Ltd | Manufacturing | 2019 |
| Deluxe Home Furniture Ltd | Other services | 2019 |
| Denise Park Limited | Health & social care | 2014 |
| Dent Corporation Ltd | Hospitality | 2025 |
| Dent Developments Limited | Construction | 2017 |
| Dent Holdings Group Ltd | Financial services | 2025 |
| Design 4 Solutions Limited | Professional & scientific | 2011 |
| Designtank Limited | Information & communication | 2009 |
| Desire Branding Limited | Extraterritorial | 2021 |
| Development 4 Limited | Professional & scientific | 2007 |
| DGR Homeservices Limited | Construction | 2023 |
| DH Superbikes & Race Parts Limited | Wholesale & retail | 2019 |
| Dht.Health Limited | Professional & scientific | 2024 |
| Dick Leigh LLP | | 2024 |
| DIG Engineering Services Limited | Construction | 2015 |
| Digidash NW Ltd | Wholesale & retail | 2019 |
| Digital 22 Online Limited | Information & communication | 2013 |
| Digital Delivery Academy Ltd | Education | 2026 |
| DIGITAL56 Limited | Professional & scientific | 2022 |
| Dilraj (Clitheroe) Ltd | Hospitality | 2023 |
| Direct Accountancy Limited | Professional & scientific | 2023 |
| Direct Fleet Solutions Ltd | Wholesale & retail | 2025 |
| Direct Medical Solutions Ltd | Health & social care | 2010 |
| Directfrom Ltd | Wholesale & retail | 2010 |
| Discover Retail Limited | Administrative & support | 2005 |
| Distinct Dwellings Ltd | Real estate | 2025 |
| Distinctive Designer Furniture Ltd | Wholesale & retail | 2019 |
| Dito Capital Limited | Administrative & support | 2014 |
| Dixy Chicken Clitheroe Ltd | Hospitality | 2023 |
| Dixy Clitheroe Limited | Hospitality | 2026 |
| Djwsuppliers Ltd | Wholesale & retail | 2019 |
| Djww Ltd | Transport & logistics | 2025 |
| DKN Powerline Limited | Professional & scientific | 2000 |
| DLA Financial Services Limited | Financial services | 2009 |
| DMA88 Holdings Ltd | Financial services | 2025 |
| DNK Event Services Ltd | Administrative & support | 2019 |
| DO Street Food Clitheroe Ltd | Hospitality | 2026 |
| DO Street Food Limited | Hospitality | 2026 |
| Dometic Mobile Cooking UK Ltd | Administrative & support | 2009 |
| Donkeys Grazing Co Ltd | Agriculture & fishing | 2009 |
| Double Dragon Restaurant Ltd | Hospitality | 2022 |
| Double H Homes Ltd | Real estate | 2021 |
| Douglas Agri Ltd | Wholesale & retail | 2018 |
| Dowbiggin Agriculture Ltd | Agriculture & fishing | 2022 |
| Dowen Orthopaedics Limited | Health & social care | 2019 |
| Dowling Magnets Europe Ltd | Extraterritorial | 2002 |
| Downham School Limited | Education | 2011 |
| Downie Developments Ltd | Construction | 2024 |
| DPS Consultancy Ltd | Financial services | 2025 |
| DR Kathryn Atkinson Ltd | Health & social care | 2024 |
| DR Memon Dermatology Services Limited | Professional & scientific | 2004 |
| DR Natalie Academy Ltd | Education | 2023 |
| DR Natalie Haworth Ltd | Health & social care | 2023 |
| DR Natalie Ltd | Health & social care | 2016 |
| DR Ralph Pickup Limited | Health & social care | 2020 |
| DR Rams Ltd | Health & social care | 2010 |
| DR50 Holdings Ltd | Financial services | 2025 |
| Dragon Drugstores (Morriston) Limited | Administrative & support | 1975 |
| Dragon Ventures Ltd | Arts & recreation | 2009 |
| Drain Care & Repair NW Ltd | Construction | 2026 |
| Dream Venues Ltd | Hospitality | 2022 |
| Driscolls Antiques Limited | Wholesale & retail | 2003 |
| Driver Limited | Administrative & support | 1999 |
| Driwell Holdings Ltd | Financial services | 2017 |
| DRY Living Solutions Ltd | Construction | 2018 |
| DSE (Builders) Ltd | Construction | 2012 |
| DSG Mobile Catering Services Ltd | Hospitality | 2026 |
| DT Events Catering Ltd | Hospitality | 2026 |
| Duck Bill Technical Engineering Services Ltd | Professional & scientific | 2018 |
| Duckworth Estate Company Limited | Real estate | 2019 |
| Duerden Removals Ltd | Transport & logistics | 2026 |
| Dugdale Merchants Limited | Wholesale & retail | 1991 |
| Dugdale Nutrition International Limited | Agriculture & fishing | 2014 |
| Dugdale Nutrition Limited | Manufacturing | 1934 |
| Duma Services Limited | Financial services | 2015 |
| Dunn Group Construction Ltd | Construction | 2026 |
| Dunsire Limited | Wholesale & retail | 2015 |
| Dunsop Bridge Trout Farm Ltd | Agriculture & fishing | 2011 |
| Durton Homes Ltd | Construction | 2023 |
| DW Ceilings Ltd | Construction | 2001 |
| DXT Construction Ltd | Construction | 2025 |
| DYNAMICALLY1 Ltd | Information & communication | 2015 |
| E Swales (Clitheroe) Limited | Hospitality | 2010 |
| E Templeman Limited | Wholesale & retail | 2011 |
| E-Quip Business Services Ltd | Professional & scientific | 2018 |
| E-Quip Property Ltd | Households | 2018 |
| E.A. Technical Services Limited | Manufacturing | 1999 |
| E.B.B. Garages Limited | Real estate | 2012 |
| Eagle Cars Private Hire Ltd | Transport & logistics | 2019 |
| Eagle Properties & Development Ltd | Construction | 2020 |
| Early Minds Nursery Ltd | Education | 2026 |
| Earthbound Electrical Group Ltd | Construction | 2026 |
| Easle Property Investments Limited | Real estate | 2019 |
| East Lancs Epcs Limited | Professional & scientific | 2025 |
| East Lancs. School of Dancing Limited | Arts & recreation | 2003 |