| Social Sisters Agency Ltd | Professional & scientific | 2025 |
| Soielet Limited | Financial services | 2023 |
| Solar Power PV Ltd | Construction | 2010 |
| Solaris GB Limited | Information & communication | 2002 |
| Soliman Medical Limited | Health & social care | 2022 |
| Somax Kitchens Limited | Construction | 2009 |
| Soney Ltd | Professional & scientific | 2023 |
| Soop UK Ltd | Hospitality | 2021 |
| Sorrento Solutions Limited | Administrative & support | 2023 |
| Soul Sister Retreats Limited | Extraterritorial | 2022 |
| Source and Secure Ltd | Real estate | 2025 |
| South Survey Holdings Limited | Financial services | 2024 |
| South Survey Limited | Wholesale & retail | 2002 |
| SP Health & Fitness Company Ltd | Arts & recreation | 2024 |
| Sparkela Limited | Hospitality | 2024 |
| Specialised Automotive Services Limited | Wholesale & retail | 1999 |
| Speedy Goat Commerce Ltd | Administrative & support | 2023 |
| Spinning Block Ltd | Hospitality | 2016 |
| Spirit Elec Limited | Construction | 2023 |
| Sports Massage Association Ltd | Other services | 2001 |
| Sports Medicine and Performance Ltd | Administrative & support | 2023 |
| SPORTS360 Limited | Arts & recreation | 2025 |
| Spot Solutions Ltd | Construction | 2023 |
| Spotlight Homes Limited | Financial services | 2005 |
| Spring Bridge Ltd | Professional & scientific | 2024 |
| Spring Clean by Leoni Ltd | Administrative & support | 2025 |
| Springboard Business Support Limited | Extraterritorial | 2020 |
| Springlane Properties Limited | Real estate | 2015 |
| Springwood Consultants Limited | Professional & scientific | 2016 |
| SRP Offroad Limited | Wholesale & retail | 2023 |
| Ssje Ltd | Real estate | 2015 |
| Ssje Properties Ltd | Real estate | 2025 |
| Staines Contractors Ltd | Agriculture & fishing | 2026 |
| Staines Services Ltd | Other services | 2021 |
| Stallington Hall Developments Limited | Wholesale & retail | 2007 |
| Stamford Carpentry Services Ltd | Construction | 2005 |
| Stansfield Holdings Ltd | Real estate | 2025 |
| Starc Construction Ltd | Construction | 2020 |
| Stargazing Holdings Limited | Financial services | 2025 |
| Stargazing Property Ltd | Real estate | 2024 |
| Stately Lighting Ltd | Wholesale & retail | 2011 |
| STC Joinery and Building Ltd | Construction | 2023 |
| Stelf Group Limited | Wholesale & retail | 2019 |
| Stelvio Holdings Ltd | Financial services | 2020 |
| Stepback Limited | Professional & scientific | 2020 |
| Stephens Ventures Ltd | Information & communication | 2014 |
| Sterling Valets & Cleaning Services Ltd | Administrative & support | 2024 |
| Steven Hargreaves Textile Group Limited | Manufacturing | 2003 |
| Steven Hargreaves Textiles Limited | Extraterritorial | 2003 |
| Steven-Hargreaves Limited | Extraterritorial | 2012 |
| Stockdales Group Ltd | Construction | 2022 |
| Stockpole Limited | Agriculture & fishing | 1987 |
| Stones Throw Lettings Ltd | Real estate | 2022 |
| Stonyhurst | Education | 2008 |
| Stonyhurst College Developments Limited | Hospitality | 1980 |
| Stonyhurst International Limited | Education | 2017 |
| Stories of Events Ltd | Arts & recreation | 2020 |
| Stork & Alphabet Ltd | Wholesale & retail | 2015 |
| Stringer Construction Ltd. | Construction | 1999 |
| Studio Bakery Limited | Manufacturing | 2018 |
| Studio Dark Ltd | Information & communication | 2026 |
| Studio Foods Limited | Wholesale & retail | 2020 |
| Studio Spielen Ltd | Professional & scientific | 2022 |
| Sugar and Layer Cake Company Ltd | Manufacturing | 2018 |
| Sugar Hill Farm Limited | Agriculture & fishing | 2023 |
| Sugar Hill Services Ltd | Administrative & support | 2026 |
| Sun Music Ltd | Information & communication | 2004 |
| Sunderland Peacock & Associates Limited | Professional & scientific | 2003 |
| Sunshine Catering Ltd | Hospitality | 2026 |
| Surelock Storage Solutions Ltd | Administrative & support | 2024 |
| Surface Repair Ltd | Construction | 2017 |
| Surface Repairs London Limited | Construction | 2018 |
| Surplus Solutions Group Ltd | Wholesale & retail | 2022 |
| Survey Scanner Hire Limited | Administrative & support | 2010 |
| SUSHIFUL786 Limited | Hospitality | 2023 |
| SW19 Consultants Ltd | Administrative & support | 2013 |
| Swallow Contractors Ltd | Construction | 2023 |
| Sweet Artist Trading Ltd | Wholesale & retail | 2022 |
| Sweetlove Training Limited | Education | 2011 |
| Swires Holdings Ltd | Financial services | 2025 |
| Switch Infrastructure Limited | Construction | 2023 |
| Swoof Limited | Wholesale & retail | 2021 |
| Symulos Ltd | Information & communication | 2022 |
| Synagy Consulting Ltd | Information & communication | 2016 |
| System Safety Solutions Limited | Professional & scientific | 2008 |
| Szahmed Ltd | Health & social care | 2022 |
| T & J Haulage Limited | Transport & logistics | 1997 |
| T Millen Creative Ltd | Professional & scientific | 2024 |
| TAG Sports North West Ltd | Arts & recreation | 2025 |
| Taggart AB24 Ltd | Real estate | 2024 |
| Tagma Marketing Ltd | Administrative & support | 2025 |
| Take the North Ltd. | Transport & logistics | 2025 |
| Talbot Parker Ltd | Professional & scientific | 2020 |
| Tapas Forty Seven Limited | Hospitality | 2022 |
| Taps (NW) Limited | Wholesale & retail | 2003 |
| Tari Medical Services Ltd | Health & social care | 2010 |
| Taste of India (Clitheroe) Ltd | Hospitality | 2022 |
| Taylor MEP Limited | Professional & scientific | 2025 |
| Tazian Limited | Manufacturing | 2009 |
| TBF (NO.1) Limited | Financial services | 2017 |