| Sandygate Cars & Commercials Ltd | Wholesale & retail | 2022 |
| Sanger Associates PVT. Ltd | Health & social care | 2015 |
| Sarah Lang Design Ltd | Wholesale & retail | 2002 |
| Sarah Louise Walker Limited | Administrative & support | 2005 |
| Sarah's Carers and Helping Hands Ltd | Administrative & support | 2023 |
| Sarcutim Consultants Limited | Professional & scientific | 2021 |
| Sarja Retail Ltd | Wholesale & retail | 2023 |
| Sassy Pups Ltd | Other services | 2025 |
| Sawitta Thai Ltd | Hospitality | 2022 |
| Sayle LLP | | 2011 |
| Sbrah Limited | Wholesale & retail | 2022 |
| SC Global (Europe) Limited | Wholesale & retail | 2024 |
| Schofield & Associates Financial Planning Ltd | Financial services | 2014 |
| School of YOU CIC | Other services | 2024 |
| School of YOU Community CIC | Health & social care | 2026 |
| Scriven Construction Limited | Construction | 2022 |
| Scrupulous Investments Limited | Real estate | 2017 |
| SCS Recovery Ltd | Transport & logistics | 2023 |
| SCW Homes Ltd | Real estate | 2019 |
| SD Consultations Limited | Professional & scientific | 2021 |
| SDB Group Ltd | Financial services | 2025 |
| SDM Investments Ltd | Financial services | 2016 |
| SDS Technology Ltd | Administrative & support | 2005 |
| SE Socials Ltd | Professional & scientific | 2024 |
| Sean Mccardle Limited | Construction | 2003 |
| Secartransport Limited | Professional & scientific | 2011 |
| Secure Contactless Payments Ltd | Wholesale & retail | 2022 |
| Seed Agricultural Engineering Limited | Administrative & support | 1999 |
| Seekout CIC | Administrative & support | 2023 |
| Selfhood Organics Limited | Wholesale & retail | 2023 |
| Semj SPV 1 Ltd | Construction | 2022 |
| Semj SPV 2 Ltd | Construction | 2022 |
| Semj SPV 3 Ltd | Construction | 2022 |
| Sensory Shed Limited | Education | 2025 |
| Seradon North West Limited | Financial services | 2023 |
| Sezel Ltd | Professional & scientific | 2023 |
| Sfdx Labs Ltd | Information & communication | 2025 |
| SFO Consultancy Limited | Professional & scientific | 2016 |
| Shackletons Garden Centre Limited | Wholesale & retail | 2001 |
| Shad's Barber Ltd | Other services | 2022 |
| Sharmax Investments Ltd | Real estate | 2016 |
| Sharp Property Holdings Limited | Real estate | 2016 |
| Shaun Burrows Developments Ltd | Construction | 2025 |
| Shawty Property Development Limited | Real estate | 2007 |
| SHC Management Company Limited | Households | 2006 |
| She's in the Attic Limited | Professional & scientific | 2025 |
| Sheffield Sports Doctor Ltd | Health & social care | 2014 |
| Shene Limite Limited | Wholesale & retail | 2026 |
| Shene PVT Limited | Wholesale & retail | 2025 |
| Shepherdess & Stocklady Ltd | Agriculture & fishing | 2025 |
| Shireburne Park Limited | Hospitality | 1986 |
| Shone Offshore Management Limited | Administrative & support | 2022 |
| Shortash Developments Limited | Households | 1987 |
| Showring Limited | Wholesale & retail | 2005 |
| Signature Horse Boxes Ltd | Manufacturing | 2020 |
| Silica Sand Mold Limited | Mining & quarrying | 2006 |
| Silver River Properties Ltd | Real estate | 2016 |
| Silverwood Trailers Ltd | Wholesale & retail | 2024 |
| Silverwoods Limited | Extraterritorial | 2002 |
| Simca Developments Limited | Construction | 2023 |
| Simca Investments Limited | Real estate | 2019 |
| Simon Tipton Wealth Management Limited | Financial services | 2022 |
| Simple Maintenance Limited | Construction | 2010 |
| Simply Caskets Ltd | Other services | 2022 |
| Simply Staged UK Limited | Extraterritorial | 2021 |
| Singleton Brothers Limited | Construction | 2018 |
| Sinnington Trout Farms Limited | Extraterritorial | 1989 |
| Site Surveying Services Ltd | Professional & scientific | 1997 |
| Siteselect Property Management Limited | Administrative & support | 1992 |
| SIX8 Creative Marketing Ltd | Professional & scientific | 2025 |
| Sixpenny Bridal Ltd | Wholesale & retail | 2024 |
| Sizzling Greeks Limited | Hospitality | 2022 |
| Sjcomps Limited | Administrative & support | 2026 |
| Sjcteo Ltd | Wholesale & retail | 2025 |
| SJD Medical Limited | Health & social care | 2020 |
| SJO Solutions Ltd | Information & communication | 2025 |
| SJW Financial Limited | Professional & scientific | 2021 |
| Skin Aesthetics CLM Limited | Health & social care | 2023 |
| Skirden Beck Holding Company Ltd | Financial services | 2024 |
| Skirden Beck Trading Company Ltd | Hospitality | 2024 |
| SKJ Futures Limited | Real estate | 2022 |
| Sky Beach Holdings Ltd | Financial services | 2016 |
| Skyline Extensions Ltd | Construction | 2025 |
| Slaidburn Property Trust | Real estate | 2002 |
| Slater Kenyon Limited | Professional & scientific | 2019 |
| SLH Sales Ltd | Professional & scientific | 2025 |
| Slitting Properties Ltd | Manufacturing | 2009 |
| SM Bennett Creations Limited | Administrative & support | 2019 |
| Smaldon Signs & Vehicle Graphics Limited | Professional & scientific | 2020 |
| Smart Choice Deals Ltd | Wholesale & retail | 2019 |
| Smarter Marketing Limited | Wholesale & retail | 2024 |
| Smartstart Innovations Ltd | Information & communication | 2024 |
| Smithies House Property Management Limited | Real estate | 2010 |
| Smyth Consultants Limited | Financial services | 2022 |
| Sniz Ltd | Information & communication | 2019 |
| Snow White Laundrette Ltd | Other services | 2022 |
| Snuffycat Enterprises Limited | Real estate | 2024 |
| Soapranos Cleaning Services Ltd | Other services | 2015 |
| Soar Contracts Limited | Construction | 2010 |
| Social Inclusion for Dyslexia | Education | 2014 |