| Deli Kitchen Healthy Food Ltd | Hospitality | 2019 |
| Delicate Dreams Limited | Wholesale & retail | 2006 |
| Delivery PAL Ltd | Transport & logistics | 2025 |
| Delta T MEP Ltd | Construction | 2015 |
| Deluxe Kitchens Limited | Construction | 2003 |
| Demand Colony Ltd | Information & communication | 2021 |
| Demand Integration Ltd | Information & communication | 2022 |
| Demofirm Limited | Information & communication | 2005 |
| Demolition & Dismantling (Chorley) Limited | Construction | 2017 |
| Demolition & Dismantling (NW) Limited | Administrative & support | 2008 |
| Demon Domestics Ltd | Households | 2019 |
| DEN Contracts (NW) Limited | Extraterritorial | 2014 |
| Denaflo Ltd | Wholesale & retail | 2026 |
| Denatec Holdings Ltd | Financial services | 2022 |
| Denatec Limited | Professional & scientific | 2020 |
| Denfords Limited | Construction | 2009 |
| Deniz's Kitchen Limited | Hospitality | 2024 |
| Denpel Ltd | Construction | 2015 |
| Denvar Personnel Limited | Administrative & support | 2019 |
| Denver IP Ltd | Information & communication | 2018 |
| Depro Ltd | Manufacturing | 2009 |
| Derai Tandoori Ltd | Hospitality | 2019 |
| Derby Vehicles Ltd | Manufacturing | 2016 |
| Derbyshire Stays Limited | Real estate | 2023 |
| Derbyshire Trading Limited | Wholesale & retail | 2019 |
| Derek PYE Limited | Professional & scientific | 2008 |
| Derian House Children's Hospice Shops Limited | Wholesale & retail | 1994 |
| Derian House Childrens Hospice | Health & social care | 1991 |
| Derma Body Sculpt Ltd | Wholesale & retail | 2025 |
| Derraco UK Ltd | Wholesale & retail | 2025 |
| Derv 365 Limited | Wholesale & retail | 2024 |
| Desi Cuisine Restaurant Limited | Other services | 2020 |
| Design & Technical Services (UK) Limited | Manufacturing | 2005 |
| Design Atelier Ltd | Professional & scientific | 2020 |
| Design LSC Limited | Arts & recreation | 2004 |
| Designbaron Ltd | Professional & scientific | 2010 |
| Desire Hair Ltd | Other services | 2016 |
| Detail and Protect Limited | Wholesale & retail | 2020 |
| Deutschscot Solutions Limited | Professional & scientific | 2021 |
| Development Solutions NW Ltd | Construction | 2025 |
| Dever Software Limited | Information & communication | 2012 |
| Devto Limited | Information & communication | 2008 |
| Dexion Direct Limited | Administrative & support | 2012 |
| Dexter Enterprise Services Limited | Professional & scientific | 2008 |
| Dexter Legal and Property Services Ltd | Professional & scientific | 2011 |
| DFC Consultancy Limited | Health & social care | 2020 |
| Dfine Media Ltd | Professional & scientific | 2024 |
| Dfine Real Estate Ltd | Real estate | 2024 |
| DG Insolvency Services Limited | Professional & scientific | 2023 |
| DG Offroad Ltd | Wholesale & retail | 2023 |
| Dgosb Holdings Limited | Administrative & support | 2019 |
| Dhayal's Catering Ltd | Hospitality | 2023 |
| DHC Door Handle Company Ltd | Wholesale & retail | 2025 |
| Dhhh Properties Ltd | Financial services | 2018 |
| DI Ferro Limited | Manufacturing | 2014 |
| DI Rita's Group Limited | Financial services | 2019 |
| DI Rita's Limited | Hospitality | 2016 |
| DI Rita's Pizzeria & Deli Limited | Hospitality | 2019 |
| Dial Time Systems Limited | Other services | 1993 |
| Diamond Accommodation Ltd | Hospitality | 2020 |
| Diamond Domestic Services Limited | Administrative & support | 2007 |
| Diamond Driveways & Landscapes Ltd | Administrative & support | 2012 |
| Diamond Seal UK Ltd | Construction | 2008 |
| Diamond Tool Warehouse Limited | Wholesale & retail | 2017 |
| Diane Berry Kitchens Limited | Wholesale & retail | 2002 |
| Dickinson Building Contractors Groundworks & Landscape Limited | Construction | 2003 |
| Dickinson Tool Hire Ltd | Administrative & support | 2023 |
| Digi Accounts and Tax Ltd | Professional & scientific | 2018 |
| Digigroup Ltd | Financial services | 2020 |
| Digital Clarity Ltd | Information & communication | 2019 |
| Digital Coach Tutor Limited | Information & communication | 2025 |
| Digital Health Limited | Health & social care | 2020 |
| Digital Nomad Accountant Limited | Education | 2021 |
| Digital Wrap Solutions Limited | Manufacturing | 2012 |
| Digital-E-Brochures Limited | Information & communication | 2007 |
| Digitly Limited | Transport & logistics | 2014 |
| Dignifiedcare Group Limited | Professional & scientific | 2019 |
| Dignity Healthcare Personnel Ltd | Administrative & support | 2021 |
| Dine in Ltd | Hospitality | 2020 |
| Dining Direct Limited | Wholesale & retail | 2008 |
| Direct Doors & Fittings Limited | Manufacturing | 2014 |
| Direct Education Limited | Other services | 1997 |
| Direct Landscapes Limited | Wholesale & retail | 2006 |
| Direct Parts Supply Limited | Wholesale & retail | 2010 |
| Directions Healthcare Ltd | Administrative & support | 2022 |
| Dirt Bike Spec. Limited | Wholesale & retail | 2014 |
| Discussion Box Ltd | Information & communication | 2019 |
| Disklok UK Limited | Wholesale & retail | 2018 |
| Distributed Energy Project Services Limited | Construction | 2017 |
| Dive Experience Limited | Arts & recreation | 2012 |
| Dixies Sixty Limited | Transport & logistics | 2012 |
| Dizzy Duck Designs Ltd | Wholesale & retail | 2016 |
| DJ Autos & Recovery Limited | Wholesale & retail | 2021 |
| DJ Boston Property Ltd | Real estate | 2025 |
| DJ Darcy Ltd | Construction | 2023 |
| Djackson Limited | Wholesale & retail | 2022 |
| DJB 1221 Ltd | Real estate | 2025 |
| DJC People Consulting Limited | Professional & scientific | 2026 |
| DJS (Chorley) Limited | Professional & scientific | 2009 |
| DKB Transport Limited | Transport & logistics | 2017 |