| Deller Enterprises Limited | Real estate | 2019 |
| Delta Business Systems Limited | Information & communication | 1998 |
| Deltae Systems Ltd | Information & communication | 2026 |
| Delves Financial Consultancy Limited | Financial services | 2022 |
| Delves Yachts Limited | Wholesale & retail | 2025 |
| Demarchi Properties Limited | Financial services | 2016 |
| Demka Limited | Administrative & support | 2008 |
| Denesgate Limited | Professional & scientific | 2009 |
| Dentrain Limited | Education | 2000 |
| Dentsure Limited | Wholesale & retail | 1995 |
| Denyers National Estate Maintenance Limited | Administrative & support | 2019 |
| Denzil Baird Ltd | Financial services | 2022 |
| Dependable Ltd | Administrative & support | 2009 |
| Deploy Digital Ltd | Information & communication | 2017 |
| Derbyshire Ltd | Real estate | 2024 |
| Derek Warwick Developments Limited | Construction | 2007 |
| Dermapharm Limited | Extraterritorial | 1997 |
| Derriads House Management Company Limited | Professional & scientific | 1984 |
| Derrick and SON Limited | Construction | 2014 |
| Descartes Kontainers Limited | Information & communication | 2014 |
| Descartes Systems UK Limited | Information & communication | 1990 |
| Design Sheep Limited | Information & communication | 2014 |
| Design Workshop (Clifton) Ltd | Professional & scientific | 2019 |
| Designduo Limited | Professional & scientific | 2012 |
| Detail Jobs Limited | Administrative & support | 2009 |
| Devaki Lettings Ltd | Real estate | 2022 |
| Developme Coaching Ltd | Professional & scientific | 2022 |
| Devineconsultants Ltd | Information & communication | 2025 |
| Devizes Fire Protection Ltd. | Administrative & support | 2003 |
| DGS Data Generating Services Limited | Professional & scientific | 1998 |
| Diamond Web Studios Limited | Information & communication | 2024 |
| DIB Insurance Limited | Financial services | 2004 |
| Dickinson Investments Limited | Real estate | 2025 |
| Digger School Ltd | Extraterritorial | 2023 |
| Digipedia Services Ltd | Information & communication | 2003 |
| Digiprint Bath Limited | Manufacturing | 2008 |
| Digiprint Chippenham Limited | Manufacturing | 2002 |
| Digiprint House Limited | Financial services | 2019 |
| Digitonas Limited | Information & communication | 2021 |
| Dineindulge Ltd | Hospitality | 2009 |
| Direct Cleaning Services SW Limited | Administrative & support | 2015 |
| Direct Medical Assistance Ltd | Professional & scientific | 2025 |
| Discfield Limited | Real estate | 1982 |
| Discover Travel Intl Ltd | Administrative & support | 2019 |
| Dixon Civils Ltd | Professional & scientific | 2024 |
| Dixon Equip Ltd | Wholesale & retail | 2021 |
| DJ Financial Advice Ltd | Financial services | 2006 |
| DJM Forestry Ltd | Agriculture & fishing | 2019 |
| Djmol Holdings Limited | Financial services | 2025 |
| DK Autosales Ltd | Wholesale & retail | 2020 |
| DKJ Plumbing and Heating Ltd | Construction | 2023 |
| DLG Investments Ltd | Financial services | 2013 |
| DLR Clearance Ltd | Transport & logistics | 2021 |
| DM Agency and Distribution Limited | Wholesale & retail | 2012 |
| DM Marquees Ltd | Administrative & support | 2015 |
| Dmco UK 01 Ltd | Real estate | 2026 |
| DMI Home Finance Limited | Financial services | 2013 |
| Dmnd Digital Ltd | Extraterritorial | 2021 |
| Dobsons (Notaries Public) Ltd | Professional & scientific | 2018 |
| Dodford Farm Daycare Nursery Limited | Education | 2003 |
| Dogs Rock Ltd | Other services | 2023 |
| Dojo Community Hub CIC | Education | 2026 |
| Domarulen Ltd | Professional & scientific | 2026 |
| Done & Sons Ltd | Other services | 2014 |
| Donoghue Developments Limited | Construction | 2025 |
| Doodson Accountancy Services Limited | Professional & scientific | 2019 |
| Doorway Wiltshire Limited | Health & social care | 2010 |
| Dorecare Company Limited | Health & social care | 2024 |
| Dorpo Digital EU Ltd | Professional & scientific | 2026 |
| Dosa Designs Limited | Wholesale & retail | 2023 |
| Dosing Solutions Limited | Manufacturing | 1996 |
| Doust Enterprises Ltd | Real estate | 2022 |
| Dovellion Limited | Information & communication | 1985 |
| Doyles Barbershop Limited | Other services | 2026 |
| DPC4LIFE Ltd | Health & social care | 2020 |
| DR Helen Eckley Facial Aesthetics Ltd | Health & social care | 2023 |
| DR KK Aesthetics Limited | Other services | 2019 |
| Drages Property Solutions Limited | Hospitality | 2016 |
| Drainwizards 24/7 Ltd | Construction | 2007 |
| Dreamscape Services Limited | Construction | 2007 |
| Drip Automotive Ltd | Administrative & support | 2021 |
| Driven Innovations Ltd | Information & communication | 2024 |
| Dronewrx Ltd | Administrative & support | 2026 |
| DRS Supported Living Limited | Health & social care | 2025 |
| DRY Home Solutions (Swindon) Limited | Construction | 2025 |
| Dryad Land & Tree Care Limited | Agriculture & fishing | 2000 |
| DT Lucky Star Nails Ltd | Other services | 2025 |
| DTG Associates Limited | Professional & scientific | 2023 |
| Dual C Consulting Limited | Professional & scientific | 2023 |
| Duckett Maintenance Ltd | Construction | 2025 |
| Dulce Vida Ltd | Information & communication | 2024 |
| Durden-Myers & Co Ltd | Financial services | 2025 |
| Dusk LAB Group Ltd | Manufacturing | 2024 |
| Dusk LAB Investments Ltd | Real estate | 2026 |
| DW Dog Training and Pet Care Ltd | Other services | 2019 |
| Dwyford Ltd | Real estate | 2020 |
| DYF Ltd | Information & communication | 2023 |
| Dymag Technologies Limited | Manufacturing | 2024 |
| Dynamic Workplace Limited | Information & communication | 2008 |
| E & M J Properties Ltd | Real estate | 2019 |