| Studio Butter Ltd | Professional & scientific | 2012 |
| Studio RB Ltd | Wholesale & retail | 2015 |
| Studio Ziga Ltd | Professional & scientific | 2024 |
| Stumble OUT Pubs Ltd | Hospitality | 2024 |
| Stumpmen Limited | Administrative & support | 2019 |
| Stutu Cleaning Services Limited | Administrative & support | 2023 |
| Stylehouse Consultancy Limited | Professional & scientific | 2022 |
| Stylehouse Developments Limited | Construction | 2024 |
| SUB7 Ltd | Hospitality | 2011 |
| Subsonic IT Ltd | Information & communication | 2018 |
| Substance With Soul Limited | Professional & scientific | 2023 |
| Success CXP Capital Ltd | Other services | 2019 |
| Success CXP Futures Ltd | Extraterritorial | 2019 |
| Success CXP Ltd | Professional & scientific | 2011 |
| Suffrajetz Ltd | Hospitality | 2025 |
| Sugacane Toys Ltd | Wholesale & retail | 2015 |
| Sugar Haven Ltd | Hospitality | 2024 |
| Sugar Snap Parties Ltd | Other services | 2022 |
| Sugarhill Consulting Limited | Information & communication | 2012 |
| Sugercain (UK) Limited | Real estate | 2022 |
| Suisso Limited | Real estate | 2011 |
| Summerfield Management Limited | Real estate | 2007 |
| Summit Property & Groundworks Limited | Construction | 2026 |
| Summit SVR Ltd | Wholesale & retail | 2025 |
| Sun & TAN Ltd | Other services | 2024 |
| Sun Leisure Holdings Limited | Wholesale & retail | 2023 |
| Sun Leisure Limited | Wholesale & retail | 2002 |
| Sun Shine & Light Ltd | Administrative & support | 2026 |
| Sunflowers Homecare Services Ltd | Health & social care | 2022 |
| Sunflowers Nursery (Holmgate) C.I.C. | Education | 2014 |
| Sunkiss UK Ltd. | Other services | 1996 |
| Sunningdale Property Services Limited | Real estate | 2022 |
| Sunniside Homes Limited | Real estate | 2017 |
| Sunrise 8866 Ltd | Hospitality | 2023 |
| Suon Developments Limited | Hospitality | 2016 |
| Suon Fiduciary Limited | Financial services | 2019 |
| Suon Holdings Limited | Financial services | 2020 |
| Suon Limited | Real estate | 1980 |
| Supake Ltd | Information & communication | 2007 |
| Superbolt (UK) Limited | Extraterritorial | 2010 |
| Superior Wellness Ltd | Manufacturing | 2011 |
| Supernews Stores Limited | Wholesale & retail | 2001 |
| Supplements Made Simple Ltd | Manufacturing | 2018 |
| Supplemintdealshut Ltd | Wholesale & retail | 2026 |
| Supreme Facial Aesthetics Ltd | Other services | 2024 |
| Surebuild Chesterfield Limited | Construction | 2011 |
| Surena Food Ltd | Hospitality | 2025 |
| Surepath Consulting Limited | Education | 2015 |
| Surepath Training Limited | Education | 2012 |
| Survey Services Limited | Professional & scientific | 2004 |
| Susan Jane Art Ltd | Wholesale & retail | 2023 |
| Sustainable Solutions Environment, Safety and Health for Business Ltd | Professional & scientific | 2022 |
| Suzanne Stone Holdings Limited | Households | 2018 |
| SVS (Chesterfield) Limited | Real estate | 2019 |
| SW Commercial Services Limited | Construction | 2016 |
| SW Retrofit Ltd | Professional & scientific | 2026 |
| Swallownest Land Ltd | Real estate | 2026 |
| Swallownest Properties Ltd | Real estate | 2024 |
| Sweeney Property Solutions Ltd | Construction | 2025 |
| Sweeps Chimney Services Ltd | Administrative & support | 2025 |
| Sweet Management & Maintenance Ltd | Real estate | 2026 |
| Sweet Tops Ltd | Hospitality | 2020 |
| Sweet! Let's EAT Ltd | Hospitality | 2022 |
| Swiftpropertydeals Ltd | Real estate | 2025 |
| Swing & Stack Doors Limited | Manufacturing | 2024 |
| Switch Electrical Supplies Limited | Wholesale & retail | 2018 |
| Switchbox Express Limited | Wholesale & retail | 2017 |
| SWS Contract Services Ltd | Extraterritorial | 2023 |
| Syndicate 1990 Limited | Financial services | 2024 |
| Synergy Sports Academy Ltd | Extraterritorial | 2013 |
| Synergy UCM Ltd | Professional & scientific | 2007 |
| Synergy Wealth Solutions Limited | Financial services | 2020 |
| Syntropy Automation Services Limited | Construction | 2026 |
| Syolo Ltd | Information & communication | 2018 |
| System Q Limited | Manufacturing | 1994 |
| SZN Hair Ltd | Other services | 2025 |
| T & J Electrics (Chesterfield) Limited | Construction | 2017 |
| T & J Electrics Limited | Construction | 1996 |
| T & R Supplies Ltd | Wholesale & retail | 2009 |
| T & S Roofline Limited | Construction | 2021 |
| T a Mason Ltd | Professional & scientific | 2003 |
| T F Rendering Solutions Ltd | Construction | 2025 |
| T G Lilleyman & SON Limited | Professional & scientific | 1936 |
| T Godber Limited | Construction | 2017 |
| T J Aspinall Limited | Wholesale & retail | 2009 |
| T L T Transport Ltd | Transport & logistics | 2004 |
| T N Renewable Energy Limited | Construction | 2023 |
| T P Mechanical Management Ltd | Professional & scientific | 2017 |
| T S Topham Building Services Ltd | Construction | 2023 |
| T Whapplington Limited | Water & waste | 2008 |
| T Wilson Estate Agents Limited | Real estate | 2008 |
| T Witcutt Limited | Wholesale & retail | 2024 |
| T'Industry Ltd | Hospitality | 2024 |
| T. & M. Scott (Properties) Limited | Real estate | 1964 |
| T. Nutt & Sons Limited | Wholesale & retail | 1962 |
| T.D.I. Training Limited | Extraterritorial | 2010 |
| T.G. Beighton Limited | Construction | 1972 |
| T.Greenworks Ltd | Construction | 2012 |
| T.H. Stockton Limited | Construction | 1984 |
| T.L. Care Limited | Health & social care | 1994 |