| Sherwood Properties (Yorkshire) Ltd | Real estate | 2022 |
| Shill Build Limited | Construction | 2010 |
| Shine on Designs Limited | Administrative & support | 2009 |
| Shinka Holdings Limited | Financial services | 2026 |
| Shinka Partners Limited | Information & communication | 2025 |
| Shinsekei Ltd | Hospitality | 2019 |
| Shinx Electrical Ltd | Construction | 2026 |
| Shire Bridge Limited | Hospitality | 2016 |
| Shire Building Supplies (Nottingham) Limited | Wholesale & retail | 2023 |
| Shire Construction Products Limited | Manufacturing | 2019 |
| Shire Insulation Limited | Wholesale & retail | 2024 |
| Shirebrook Self Storage Limited | Administrative & support | 2017 |
| Shirehall Haulage Limited | Transport & logistics | 2021 |
| Shireoaks Ltd | Construction | 2024 |
| Shires Plant & Equipment Ltd | Construction | 2021 |
| Shmidt & Shmidt Limited | Transport & logistics | 2025 |
| SHOES4LESS Ltd | Wholesale & retail | 2026 |
| Shoesign Limited | Wholesale & retail | 2002 |
| SHOP4BIKERS Ltd | Wholesale & retail | 2011 |
| Short & SON Engineering Ltd | Manufacturing | 2023 |
| Short Engineering Services Limited | Manufacturing | 2007 |
| Short Trustees Limited | Professional & scientific | 1993 |
| Shorten Solutions Limited | Information & communication | 2010 |
| Shoulder of Mutton Hasland Ltd | Professional & scientific | 2019 |
| Showcase Imagery Limited | Professional & scientific | 2025 |
| Shubbs Logistics Ltd | Transport & logistics | 2021 |
| Shumz Holdings UK Ltd | Financial services | 2021 |
| Shuttlewood Motor Group Ltd | Wholesale & retail | 2020 |
| Shuttlewood Stores Ltd | Wholesale & retail | 2021 |
| Siba Traders Ltd | Hospitality | 2026 |
| Sibomotors Limited | Wholesale & retail | 2024 |
| Sid's Dog Walking Limited | Other services | 2009 |
| Siddall's Property Ltd | Real estate | 2012 |
| Siddall's Roofing Supplies Limited | Wholesale & retail | 2002 |
| Sigful Ltd | Information & communication | 2025 |
| Sigma Thermal UK & Europe Ltd | Wholesale & retail | 2018 |
| Silas J. Lees Limited | Real estate | 2015 |
| Silicon Magic Limited | Information & communication | 1996 |
| Silk Management Company Limited | Households | 2016 |
| Silux Control UK Ltd | Wholesale & retail | 2019 |
| Silver Lining Pubs Limited | Hospitality | 2011 |
| Silver Shell Limited | Manufacturing | 2016 |
| Silver Sixpence Florist Ltd | Wholesale & retail | 2023 |
| Silver Treehouse Ltd | Information & communication | 2022 |
| Silverhill Edge Residents Management Company Limited | Households | 2026 |
| Silverhouse Group Limited | Wholesale & retail | 2008 |
| Silverlining Counselling and Psychotherapy Ltd | Health & social care | 2021 |
| Silverswift Computing Limited | Information & communication | 1991 |
| SIM & Skills Limited | Wholesale & retail | 2020 |
| Sima Properties Ltd | Real estate | 2018 |
| Simon COY Limited | Other services | 2014 |
| Simon Ford Media Ltd | Professional & scientific | 2016 |
| Simon Jackson Properties Ltd | Real estate | 2023 |
| Simon Mounsey Limited | Information & communication | 2003 |
| Simon Pike Carpets Ltd | Construction | 2024 |
| Simon Taylor T a Walgrove Garage Limited | Wholesale & retail | 2014 |
| Simona Peak Pipe Systems Limited | Manufacturing | 2012 |
| Simple Accounts and Tax Ltd | Professional & scientific | 2016 |
| Simpleworx Ltd | Information & communication | 2011 |
| Simpli B2B Ltd | Wholesale & retail | 2024 |
| Simply Agri Limited | Wholesale & retail | 2018 |
| Simply AI Solutions Ltd | Information & communication | 2026 |
| Simply Arena Mirrors Ltd | Manufacturing | 2015 |
| Simplyastag Cards Limited | Wholesale & retail | 2025 |
| Simpson Property Services (EM) Limited | Construction | 2016 |
| Singh Sall Estates Limited | Real estate | 2015 |
| Singh Sall Residential Ltd | Real estate | 2024 |
| Single Sauce Limited | Professional & scientific | 2025 |
| Sintech Services Ltd | Information & communication | 2025 |
| Sirj Pharma Ltd | Wholesale & retail | 2022 |
| SIS Global Limited | Information & communication | 2016 |
| SIS-7 Ltd | Administrative & support | 2010 |
| Sisi LI Consultant Ltd | Professional & scientific | 2024 |
| Sita Property Limited | Real estate | 2017 |
| Site Blasting Services Ltd | Administrative & support | 2023 |
| Site Dynamix UK Limited | Information & communication | 2021 |
| Sitecast Services Ltd | Construction | 2017 |
| Sivil Design & Build Limited | Construction | 2001 |
| Sivils Limited | Construction | 2026 |
| SIX Type Ltd | Water & waste | 2025 |
| SJ Maintenance and Construction Ltd | Construction | 2025 |
| SJ Mobile Tyres Ltd | Wholesale & retail | 2024 |
| SJ Mortgage Advice Ltd | Financial services | 2015 |
| SJB Accountancy & Taxation Services Limited | Professional & scientific | 2008 |
| SJB Rail Ltd | Professional & scientific | 2021 |
| SJB Security Limited | Administrative & support | 2021 |
| SJC Wealth Management Limited | Financial services | 2022 |
| Sjcworld Ltd | Wholesale & retail | 2025 |
| SJM Group Holdings Limited | Financial services | 2026 |
| Sjre Limited | Real estate | 2025 |
| Skaline Ltd | Financial services | 2025 |
| SKI Stop UK Limited | Wholesale & retail | 2018 |
| Skilled Engineer Ltd | Professional & scientific | 2025 |
| Skills and Funding Consultancy Group Limited | Professional & scientific | 2023 |
| Skills People Academies Limited | Education | 2009 |
| Skills People Properties Limited | Real estate | 2019 |
| Skillsterz Ltd | Professional & scientific | 2024 |
| Skin & Tonic (Chesterfield) Limited | Other services | 2023 |
| Skin & Within Ltd | Other services | 2026 |
| Skin&Spirit Hair & Beauty Limited | Other services | 2023 |