| Envy Developments Limited | Real estate | 2017 |
| Epic Small Features Ltd | Information & communication | 2025 |
| Epjs Property Services Limited | Real estate | 2024 |
| Equipment Supplies International Limited | Administrative & support | 1996 |
| Erdogan Property Investment Ltd | Real estate | 2026 |
| Ergon Developments Ltd | Construction | 2020 |
| Eric Wild & SON Limited | Administrative & support | 1991 |
| Erica Developments Ltd | Construction | 2019 |
| Erica Properties Ltd | Real estate | 2014 |
| Ericius Limited | Administrative & support | 2021 |
| Erjag Limited | Professional & scientific | 2021 |
| Ernst Blofeld Limited | Real estate | 2015 |
| ERP Advisers Limited | Information & communication | 2011 |
| ERP Support Ltd | Wholesale & retail | 2021 |
| ERS Developments Ltd | Construction | 2024 |
| ESC Dance Management Ltd | Arts & recreation | 2015 |
| ESC Environmental Services Ltd | Water & waste | 2002 |
| Escafeld Lettings Ltd | Real estate | 2025 |
| Escape Game Events Ltd | Arts & recreation | 2015 |
| Escape Travel UK Limited | Wholesale & retail | 2025 |
| ESD Electrical Ltd | Construction | 2025 |
| ESG Commercial Finance Limited | Extraterritorial | 2023 |
| Eshott Farms Limited | Administrative & support | 2008 |
| Eskal Ltd | Professional & scientific | 2022 |
| ESP Security Limited | Administrative & support | 2014 |
| Espers Holdings Limited | Real estate | 2019 |
| Espresso-Care Ltd | Manufacturing | 2024 |
| Essence Social Care Limited | Health & social care | 2023 |
| Essenkay Properties Ltd | Households | 2025 |
| Essenkay Solutions Ltd | Information & communication | 2021 |
| Essential Brands Direct UK Ltd | Wholesale & retail | 2025 |
| Essential Security Projects Ltd | Administrative & support | 2024 |
| Essential Wellness Global Ltd | Wholesale & retail | 2023 |
| Essentials Manpower Ltd | Administrative & support | 2022 |
| Established Beauty Ltd | Other services | 2020 |
| Estate Fire Safety Limited | Professional & scientific | 2021 |
| Estate Motors (Chesterfield) Ltd. | Wholesale & retail | 2006 |
| Estate Tyres (Chesterfield) Ltd | Wholesale & retail | 2003 |
| Estech Ltd | Construction | 2024 |
| Esteem Real Estate Limited | Real estate | 2021 |
| Estetico Limited | Health & social care | 2018 |
| Estructura Limited | Construction | 2009 |
| ET Power Supplies Limited | Professional & scientific | 2003 |
| Eternal Rest Limited | Other services | 2024 |
| Etgo Holdings Ltd | Financial services | 2023 |
| Etgo UK Ltd | Wholesale & retail | 2022 |
| Ethcow Ltd | Other services | 2025 |
| Ethel Construction Consultancy Ltd | Professional & scientific | 2025 |
| Etienne Curtains & Blinds Ltd | Wholesale & retail | 2019 |
| ETM Housing Ltd | Real estate | 2025 |
| Etps Employee Trust Limited | Administrative & support | 2024 |
| Etps Holdings Limited | Financial services | 2019 |
| Etps Limited | Wholesale & retail | 1999 |
| Etta Labs Ltd | Information & communication | 2025 |
| Euchner (U.K.) Limited | Wholesale & retail | 1982 |
| Euphoria Hair and Beauty (Midlands) Limited | Other services | 2016 |
| Euro Haul Transport Limited | Administrative & support | 2019 |
| Euro-Asian Parts UK Ltd | Wholesale & retail | 2011 |
| Eurocleanseas Limited | Administrative & support | 2007 |
| Europa Service Car Limited | Administrative & support | 1997 |
| Europepaymentsolutions Ltd | Financial services | 2018 |
| Eurorooflines Ltd | Construction | 2025 |
| EV Green Charging Ltd | Construction | 2021 |
| Evac UK Limited | Financial services | 2018 |
| Everfast Collated Fasteners Limited | Wholesale & retail | 2006 |
| Everguard Property Ltd | Households | 2026 |
| Everlend Maine Limited | Other services | 2020 |
| Everyday Wellbeing Support Services Ltd | Health & social care | 2026 |
| Everyone Mortgages Ltd | Professional & scientific | 2024 |
| Evie MAY Ltd | Real estate | 2026 |
| Evil a Ltd | Manufacturing | 2024 |
| EVO Property Developments Limited | Real estate | 2025 |
| EVO Superior Interiors Ltd | Construction | 2018 |
| EVO Vehicle Conversions Limited | Wholesale & retail | 2014 |
| Evoluted Holdings Limited | Financial services | 2021 |
| Evolution Funding Group Limited | Financial services | 2018 |
| Evolution Funding Limited | Financial services | 2018 |
| Evolution Hybrid Mattress Limited | Wholesale & retail | 2018 |
| Evolution Loans Limited | Financial services | 2009 |
| Evolution Motor Finance Limited | Financial services | 2018 |
| Evolution Property Maintenance Limited | Water & waste | 2015 |
| Evolve Aesthetics Chesterfield Ltd | Other services | 2019 |
| Evolve Brows Ltd | Other services | 2019 |
| EW Medtech Ltd | Professional & scientific | 2025 |
| Ewemove (Mansfield) Limited | Real estate | 2014 |
| EWT Logistics Limited | Transport & logistics | 2024 |
| Exact-O-Bore CNC Limited | Professional & scientific | 2018 |
| Exact-O-Bore Plant Limited | Professional & scientific | 2024 |
| Excavator Spares (Chesterfield) Limited | Manufacturing | 1983 |
| Excel Automotives Limited | Wholesale & retail | 2002 |
| Excel Resourcing (Recruitment Consultants) Limited | Administrative & support | 1995 |
| Excel Traffic Management Limited | Other services | 2026 |
| Excellence Assured Ltd | Professional & scientific | 2010 |
| Excelsior Limousines Ltd | Transport & logistics | 2013 |
| Exclusivia Limited | Professional & scientific | 2022 |
| Exell Engineering Limited | Manufacturing | 2003 |
| Exell Fabrications Limited | Manufacturing | 2011 |
| EXODA8 Limited | Health & social care | 2014 |
| Exoplore Ltd | Hospitality | 2021 |
| Expedite Express Ltd | Transport & logistics | 2026 |