| Deepak & Co Ltd | Health & social care | 2012 |
| Deeper Than Blue Analytics Limited | Information & communication | 2018 |
| Deeper Than Blue Group Limited | Professional & scientific | 2018 |
| Deeper Than Blue Ltd | Information & communication | 2013 |
| Deeper Than Blue Unify Limited | Information & communication | 2018 |
| Deer Park Podiatry Ltd | Health & social care | 2018 |
| Deestore Ltd | Wholesale & retail | 2025 |
| Deevin Ltd | Health & social care | 2019 |
| Deew Distributions Ltd | Wholesale & retail | 2026 |
| Defence Skills People Ltd | Education | 2009 |
| Defeye Creative Limited | Professional & scientific | 2013 |
| Defib People Ltd | Wholesale & retail | 2024 |
| DEG Consultancy Limited | Education | 2015 |
| Deja Tapas Ltd | Hospitality | 2023 |
| Delhi Trading Limited | Hospitality | 2022 |
| Delight Property Management Ltd | Real estate | 2022 |
| Delilicious Bakery & Catering Services Limited | Hospitality | 2013 |
| Delivermymembers Ltd | Transport & logistics | 2024 |
| Delivermymotor Jobs Ltd | Transport & logistics | 2024 |
| Deluxe Plant Limited | Administrative & support | 2015 |
| Demain Limited | Manufacturing | 2018 |
| Demon Collectibles Ltd | Extraterritorial | 2021 |
| Denizmavi Limited | Hospitality | 2024 |
| Denka U.K. Limited | Wholesale & retail | 2017 |
| Dennis Waste OIL Collection Limited | Water & waste | 2019 |
| Dental Express Supplies Limited | Wholesale & retail | 2018 |
| Derby Audi Limited | Extraterritorial | 1960 |
| Derby City Gymnastics Club Limited | Arts & recreation | 2000 |
| Derby Road 1966 Limited | Extraterritorial | 2014 |
| Derby Skills Academy Limited | Extraterritorial | 2020 |
| Derbyshire Asbestos Control Ltd | Water & waste | 2022 |
| Derbyshire Bespoke Bathrooms Ltd | Professional & scientific | 2025 |
| Derbyshire BIN Cleaning Limited | Information & communication | 2025 |
| Derbyshire Building Control Partnership Limited | Construction | 2015 |
| Derbyshire Business Events Limited | Other services | 2024 |
| Derbyshire Capital Ltd | Financial services | 2024 |
| Derbyshire Caravan Services Limited | Wholesale & retail | 2006 |
| Derbyshire Catering Services Ltd | Hospitality | 2025 |
| Derbyshire Child and Educational Psychology Ltd | Education | 2021 |
| Derbyshire Control Group Ltd | Construction | 2024 |
| Derbyshire Dales Properties Limited | Hospitality | 2023 |
| Derbyshire Dents Limited | Manufacturing | 2004 |
| Derbyshire Direct Holdings Ltd | Financial services | 2026 |
| Derbyshire Direct Limited | Wholesale & retail | 2023 |
| Derbyshire Dyslexia Centre Limited | Education | 2024 |
| Derbyshire Education Business Partnership Limited | Education | 2011 |
| Derbyshire Enterprise Agency Limited | Administrative & support | 1983 |
| Derbyshire Furniture Centre Limited | Wholesale & retail | 2010 |
| Derbyshire Garden Rooms Limited | Construction | 2022 |
| Derbyshire GAS Services Ltd | Construction | 2020 |
| Derbyshire GAS Solutions Limited | Construction | 2017 |
| Derbyshire Holiday Homes Limited | Hospitality | 2024 |
| Derbyshire Hose and Fittings Limited | Professional & scientific | 1993 |
| Derbyshire Industrial Services Ltd | Administrative & support | 2013 |
| Derbyshire Law Centre Ltd | Professional & scientific | 1989 |
| Derbyshire Light Medical Ltd | Health & social care | 2024 |
| Derbyshire Logistics Limited | Transport & logistics | 2020 |
| Derbyshire Marquees Ltd | Other services | 2022 |
| Derbyshire Motorhome Rental Ltd | Administrative & support | 2017 |
| Derbyshire Neon Limited | Manufacturing | 2011 |
| Derbyshire Overton Estate Farm Limited | Agriculture & fishing | 2007 |
| Derbyshire Packaging Systems Limited | Administrative & support | 1999 |
| Derbyshire PIE &Co LLP | | 2020 |
| Derbyshire Polymers Ltd | Manufacturing | 2021 |
| Derbyshire Primary Care & Commercial Services Limited | Health & social care | 2017 |
| Derbyshire Property Control Ltd | Construction | 2025 |
| Derbyshire Property Trading Limited | Real estate | 2008 |
| Derbyshire Recycling Services Limited | Water & waste | 2018 |
| Derbyshire Renewables Ltd | Construction | 2025 |
| Derbyshire Rentals Limited | Real estate | 2012 |
| Derbyshire RUM Runners Limited | Wholesale & retail | 2020 |
| Derbyshire Staycations Ltd | Hospitality | 2021 |
| Derbyshire Support and Facilities Services Limited | Administrative & support | 2018 |
| Derbyshire Training Solutions Limited | Professional & scientific | 2001 |
| Derbyshire Voluntary Action | Other services | 2009 |
| Derma-Vent UK Ltd | Other services | 2018 |
| Derrick Priestley Contracts Limited | Information & communication | 1987 |
| Derwent Rural Counselling Service | Health & social care | 2007 |
| Derwent Spire Properties Ltd | Real estate | 2023 |
| DES Healthcare (Holdings) Limited | Financial services | 2024 |
| DES Healthcare Limited | Health & social care | 2015 |
| Desigital Ltd | Information & communication | 2023 |
| Design and Development Fabrications Ltd | Manufacturing | 2012 |
| Design to Build Solutions Ltd | Construction | 2025 |
| Designer Contracts Limited | Construction | 2004 |
| Designs by Daykin Ltd | Administrative & support | 2016 |
| Despo Properties Limited | Real estate | 2024 |
| Develop to Succeed Limited | Professional & scientific | 2013 |
| Devine Koffee Chesterfield Ltd | Hospitality | 2021 |
| Devonshire International Limited | Manufacturing | 2018 |
| Devonshire Park (Chesterfield) Management Company Limited | Real estate | 2001 |
| Devonthegreen Limited | Hospitality | 2022 |
| DEW Business Associates Limited | Professional & scientific | 2024 |
| Dewsbury Riverside Limited | Construction | 2020 |
| Dexlen Ltd | Professional & scientific | 2023 |
| DEY & Co. Ltd | Professional & scientific | 2010 |
| DEY Signs Limited | Manufacturing | 2024 |
| Df-Uk Ltd | Administrative & support | 2026 |
| DFA Online Ltd | Education | 2023 |
| DFJ Consultancy Services Ltd. | Health & social care | 2011 |