| DOWN2EARTH Energy Limited | Construction | 2009 |
| Downing Fire Ltd | Professional & scientific | 2020 |
| DPE AH Limited | Real estate | 2022 |
| DPJ Occupational Health Limited | Health & social care | 2003 |
| DPM Management Ltd | Households | 2019 |
| Dpth Financial Services Ltd | Professional & scientific | 2011 |
| DR Awais Ltd | Health & social care | 2025 |
| DR C.C Harris Ltd | Health & social care | 2024 |
| DR Dominic Anglin Medical Services Limited | Health & social care | 2013 |
| DR Duncan Fullerton Respiratory Ltd | Health & social care | 2021 |
| DR Grace Bowman Ltd | Health & social care | 2025 |
| DR Hangover Ltd | Health & social care | 2024 |
| DR Rosie Wall Ltd | Health & social care | 2024 |
| DR SAG Ltd | Health & social care | 2020 |
| DR Watson Clinical Psychology Ltd | Health & social care | 2022 |
| DR. John O'Sullivan Occupational Health Limited | Health & social care | 2012 |
| DR. Linda Rush Limited | Education | 2025 |
| DR. Suhair Ltd | Health & social care | 2023 |
| Draco Developments Ltd | Construction | 2019 |
| Drago Trans Limited | Transport & logistics | 2016 |
| Dragon Grips Ltd | Information & communication | 2013 |
| Dragon Key Estates Limited | Real estate | 2025 |
| Dragon Wellbeing Ltd | Other services | 2022 |
| Dragonautos Ltd | Wholesale & retail | 2023 |
| Dragonfly Fisheries Limited | Agriculture & fishing | 2004 |
| Drain Busters (NW) Limited | Manufacturing | 2004 |
| Drake Communications Limited | Professional & scientific | 2005 |
| DRB Jewellery Limited | Wholesale & retail | 2000 |
| Drct (Phph) Ltd | Real estate | 2016 |
| Drct (SJR) Ltd | Real estate | 2016 |
| Drct Limited | Financial services | 2009 |
| Dream Above Ltd | Real estate | 2020 |
| Dream Mango Coaching Ltd | Professional & scientific | 2011 |
| Dreamteach Limited | Education | 2009 |
| Dreamteam Design Ltd | Professional & scientific | 2019 |
| Drewan Limited | Extraterritorial | 2015 |
| Drip Wear Limited | Wholesale & retail | 2025 |
| Drive Revive (NW) Ltd | Administrative & support | 2026 |
| Drive With Dorbin Ltd | Education | 2025 |
| Driving Force Recruitment Holdings Limited | Financial services | 2017 |
| Drlm Ltd | Wholesale & retail | 2024 |
| Droll Ltd | Professional & scientific | 2022 |
| Dromgooles Group Limited | Financial services | 2023 |
| Drop Honey Ltd | Manufacturing | 2024 |
| Dropifyglobal Ltd | Wholesale & retail | 2024 |
| Dropjaw Ventures Group Ltd | Information & communication | 2017 |
| Drumcote Gardens Management Company Limited | Households | 2021 |
| Drumineal Limited | Financial services | 2025 |
| Dryden Building RTM Company Ltd | Households | 2022 |
| Dryfield Consulting Limited | Information & communication | 2005 |
| DSA Family Investment Company Limited | Real estate | 2018 |
| DSF Law Ltd | Professional & scientific | 2011 |
| DSJ Development Ltd | Real estate | 2018 |
| Dsjlip Ltd | Professional & scientific | 2020 |
| DSL Asset Management (RA) Limited | Administrative & support | 2016 |
| DSL Beauty’S Ltd | Other services | 2022 |
| DST Recruitment Limited | Administrative & support | 2023 |
| DTH (NW) Limited | Real estate | 2019 |
| DTM Legal LLP | | 2008 |
| DTP Plumbing and Heating Ltd | Construction | 2017 |
| DTS Construction & Access Services Limited | Construction | 2015 |
| DTS Scaffolding Services Limited | Construction | 2010 |
| Dubai Delicious Ltd | Hospitality | 2025 |
| Dublcheck (Chester) Limited | Extraterritorial | 2000 |
| Dublcheck Cleaning Services Limited | Administrative & support | 1993 |
| Dublcheck Holdings Limited | Professional & scientific | 2011 |
| Dublcheck Limited | Administrative & support | 1996 |
| Ducat Group Limited | Professional & scientific | 2024 |
| Duck Duck Properties Ltd | Real estate | 2024 |
| Duckling Properties Ltd | Real estate | 2025 |
| Duffield Removals & Storage Ltd | Transport & logistics | 2026 |
| Duffield Removals Ltd | Transport & logistics | 2026 |
| Dukes Court (Chester) Limited | Households | 1995 |
| Dukes Manor NO 3 RTM Company Limited | Households | 2021 |
| Dukes Wood Holdings Limited | Financial services | 2024 |
| Dukht Limited | Health & social care | 2025 |
| Dukku Designs Ltd | Wholesale & retail | 2023 |
| Dulas Island Nature Conservation Limited | Construction | 2025 |
| Dunavox GB Ltd | Wholesale & retail | 2020 |
| Dunham Hill Garage Ltd | Wholesale & retail | 2014 |
| Dunmail Systems Engineering LLP | | 2025 |
| Dunnings Development Ltd | Information & communication | 2024 |
| DUO C&Z Solutions Ltd | Professional & scientific | 2025 |
| Dura Rehab Ltd | Information & communication | 2025 |
| Durrant & Company Ltd | Extraterritorial | 2025 |
| Dusk Till Dawn Enterprises Limited | Real estate | 2018 |
| Dust Collectors Shop Ltd | Wholesale & retail | 2025 |
| Dustiva Cleaning Company Limited | Administrative & support | 2025 |
| Duttons Agricultural Contractors Limited | Agriculture & fishing | 2014 |
| DV Architecture Limited | Professional & scientific | 2007 |
| DVS Diagnostics Limited | Professional & scientific | 2019 |
| DW Risk Services Ltd | Financial services | 2018 |
| DWD Taverns Limited | Hospitality | 2021 |
| Dwellon Ltd | Professional & scientific | 2023 |
| Dwlts Ltd | Professional & scientific | 2015 |
| Dynamic Ultrasound Imaging Ltd | Health & social care | 2026 |
| Dynamiqology Limited | Professional & scientific | 2022 |
| Dynamite Holdings Limited | Administrative & support | 2022 |
| Dynamite Recruitment Solutions Limited | Administrative & support | 2011 |
| Dynastyltl Ltd | Construction | 2004 |