| Crestview Property Development Ltd | Construction | 2025 |
| Crewe Stove Enamelling Company Limited | Professional & scientific | 2003 |
| CRJ Services Limited | Water & waste | 1999 |
| Cromet Limited | Real estate | 1976 |
| Cross-Country Developments Limited | Professional & scientific | 1985 |
| Crossland Resources Limited | Professional & scientific | 2005 |
| Crossley Park (Manley) Company Limited | Households | 1997 |
| Crown Logistics (UK) Limited | Administrative & support | 2001 |
| Crown Lower Peover Limited | Hospitality | 2024 |
| Crystle Limited | Wholesale & retail | 1999 |
| Csip Computing Limited | Information & communication | 2007 |
| CSJ.K9 Limited | Wholesale & retail | 2002 |
| CTA Services | | 1999 |
| CTS (Northern) Limited | Wholesale & retail | 2006 |
| Cubar Construction Company Limited | | 1956 |
| Cunninghams OPTICIANS(1934)LIMITED | Health & social care | 1934 |
| Current Technology Ltd | Extraterritorial | 1991 |
| CVS Trade Ltd | Professional & scientific | 2014 |
| Cwmtillery Glass Centre Group Limited | Financial services | 2022 |
| Cyclopse Engineering Services Limited | Professional & scientific | 2007 |
| Cytoswim Ltd | Manufacturing | 2019 |
| D & a Business Services Limited | Professional & scientific | 2003 |
| D a S Building Services Limited | Construction | 2002 |
| D B R Engineering Limited | Arts & recreation | 2007 |
| D C M Systems Limited | Construction | 2003 |
| D Chantler Transport Ltd | Transport & logistics | 2022 |
| D Connolly & SON Limited | Other services | 2002 |
| D Connor Builders Limited | Construction | 2010 |
| D H Research Limited | Professional & scientific | 2000 |
| D J Edge & Partners Limited | Agriculture & fishing | 2012 |
| D J Prout Limited | Construction | 2003 |
| D P Tyres Limited | Wholesale & retail | 2002 |
| D Philipson Electrical Limited | | 2006 |
| D&F Associates Ltd | Professional & scientific | 2008 |
| D. & C. Door Systems Limited | Wholesale & retail | 1983 |
| D. L. Evans (Properties) Limited | Real estate | 2002 |
| D. Q. Henriques Consultancy Limited | Professional & scientific | 2005 |
| D. W. Investments Limited | Extraterritorial | 1962 |
| D.A.T.S. (Holdings) Limited | Administrative & support | 1972 |
| D.L. Evans and SON (Reroofing) Limited | Construction | 1987 |
| D.L. Price (Builders) Limited | Wholesale & retail | 1978 |
| D.P.G. Developments Limited | Real estate | 1986 |
| Daanari Ltd | Professional & scientific | 2019 |
| Daisy Chain Nursery Group Limited | Financial services | 2024 |
| Dajas Ltd | Information & communication | 2007 |
| Dale Design Limited | Information & communication | 2007 |
| Damens General Trading Ltd | Wholesale & retail | 2025 |
| Damsan Ltd | Real estate | 2024 |
| DAN 16 Ltd | Transport & logistics | 2018 |
| Daniel French Ltd | Real estate | 2023 |
| Daniels & Co Developments Ltd | Real estate | 2026 |
| Daniels Computing Limited | Information & communication | 2001 |
| Dark Matter Clothing Limited | Administrative & support | 2007 |
| Datag Limited | Information & communication | 1988 |
| Datalase Ltd | Manufacturing | 1987 |
| Datascript Consultancy Services Limited | Information & communication | 1993 |
| Dave Thompson Bricklaying Limited | Construction | 2003 |
| Davenham Nursery Limited | Other services | 1999 |
| Daves of Middlewich Limited | Wholesale & retail | 2006 |
| David Andrews Homes Limited | Real estate | 2002 |
| David Chapman Accountancy Limited | Professional & scientific | 2006 |
| David Hopton Limited | Construction | 2005 |
| David Hughes Agricultural Consultancy Ltd | Agriculture & fishing | 2003 |
| David of Duke Street Limited | Other services | 2003 |
| David R Beech Barn Equipment Ltd | Construction | 2005 |
| David Whyte (Consulting and Contracting) Limited | Real estate | 2006 |
| DBL Asset Management LLP | | 2007 |
| DE LA Wyche Baker Limited | Professional & scientific | 2003 |
| DE Systems Ltd | Information & communication | 2007 |
| Deacon Dental Ltd. | Health & social care | 2007 |
| Deaconfield Limited | Real estate | 1994 |
| Decision Support Tools Limited | Information & communication | 2006 |
| Deebelle Ltd | Real estate | 2023 |
| Deeley Horton Planning & Landscapes Limited | Professional & scientific | 2006 |
| Deep Clean Hygiene Services (UK) Limited | Water & waste | 1993 |
| Deli Felice Grill Limited | Manufacturing | 2020 |
| Dementia Resource Community Ltd | Health & social care | 2020 |
| Dencas by Design Limited | Wholesale & retail | 2002 |
| Denning Place Management Ltd. | Households | 2002 |
| Dental Co-Operation Team | | 1998 |
| Dentco (Warrington) Limited | Health & social care | 2006 |
| Denton Engineering Company Limited(The) | Wholesale & retail | 1931 |
| Dependable Packs Limited | Professional & scientific | 1966 |
| Dermassure Aesthetics Ltd | Health & social care | 2020 |
| Designs AK Limited | Professional & scientific | 2018 |
| Deva Group Holdings Ltd | Administrative & support | 2000 |
| Devlin Digs Ltd | Real estate | 2026 |
| Devonshire Bakery Limited | Wholesale & retail | 2006 |
| DHD Consulting Ltd | Information & communication | 2007 |
| Diagnostic Associates Limited | Manufacturing | 2001 |
| Diamond Driveways Limited | Construction | 2003 |
| Dickenson (Estates) Limited | Real estate | 1990 |
| Digiconnect Limited | Construction | 2007 |
| Dingle Garages Limited | Real estate | 1956 |
| Dinmore Aggregates Limited | Mining & quarrying | 2016 |
| Diotte Consulting and Technology Limited | Professional & scientific | 2002 |
| Direct Systems and Controls Limited | Construction | 2002 |
| Dishonor Limited | Wholesale & retail | 2016 |
| Disley Marine and Tropical Fish | | 1987 |
| Disley Properties Limited | Real estate | 1973 |