| Dawbell Consulting Limited | Information & communication | 2008 |
| Dawtrey Winter Limited | Professional & scientific | 2002 |
| Day Developments (Cheltenham) Limited | Construction | 2006 |
| Day One Recordings Ltd | Information & communication | 2022 |
| DAY2 Health Ltd | Health & social care | 2023 |
| Daybury Electrical Services Limited | Construction | 1978 |
| Daysh DOT Ltd | Wholesale & retail | 2026 |
| Dayslane Limited | Construction | 2017 |
| Dayspring Holdings Limited | Financial services | 2024 |
| Dayspring Software Limited | Information & communication | 2024 |
| DB Partnership Limited | Arts & recreation | 2016 |
| DB Tools & Hardware Ltd | Wholesale & retail | 2025 |
| DB Tools Ltd | Wholesale & retail | 2025 |
| DBA AS a Service Limited | Information & communication | 2020 |
| DC 200 Solutions Ltd | Information & communication | 2015 |
| DC Group (Cheltenham) Ltd | Construction | 2011 |
| DC Home Builders Ltd | Construction | 2022 |
| DC Retail Consulting Ltd | Professional & scientific | 2024 |
| Dcgfx Limited | Information & communication | 2014 |
| DCL Consultants Ltd | Professional & scientific | 2017 |
| Dcmholdings Limited | Financial services | 2017 |
| Dcminvestments Limited | Real estate | 2017 |
| Dcmpriory Limited | Wholesale & retail | 2008 |
| Dcpm Limited | Construction | 2025 |
| DCS (Glos) Ltd | Transport & logistics | 2009 |
| DD Auto Repair Ltd | Wholesale & retail | 2026 |
| DD Demolition & Waste Ltd | Water & waste | 2025 |
| DD Rope Access Ltd | Construction | 2014 |
| DD Tree Services Ltd | Administrative & support | 2024 |
| DDR51 Limited | Hospitality | 2024 |
| DDV Smart Solutions Ltd | Administrative & support | 2016 |
| DE Burgh Personal Healthcare Ltd | Health & social care | 2025 |
| DE Butte Limited | Wholesale & retail | 2009 |
| DE Clifton Ltd | Professional & scientific | 2026 |
| DE Keizer Ltd | Professional & scientific | 2014 |
| DE MEL Property Limited | Real estate | 2021 |
| DE MEL Residential Lettings Ltd | Real estate | 2022 |
| DE MEL Winchcombe Limited | Real estate | 2025 |
| DE Nail Base Ltd | Other services | 2026 |
| DE Paris Restorations Limited | Construction | 2009 |
| DE Rose Wealth Management Ltd | Financial services | 2019 |
| De-Icers (M.H.G.) Limited | Manufacturing | 1984 |
| Dean Close Education Limited | Education | 2024 |
| Dean Close Nurseries Limited | Education | 2015 |
| Dean Close Services Limited | Wholesale & retail | 1991 |
| Dean Eyre Limited | Construction | 2014 |
| Dean Forest Cycles Limited | Arts & recreation | 2011 |
| Dean Tyre and Exhaust Services Limited | Wholesale & retail | 2004 |
| Deb-On-Air Travel Limited | Administrative & support | 2013 |
| Debas Associates Ltd | Information & communication | 2023 |
| Debit OR Credit Ltd | Professional & scientific | 2019 |
| Debsloveart Limited | Wholesale & retail | 2023 |
| DEC Growth Advisory Ltd | Professional & scientific | 2026 |
| Decage Limited | Construction | 1960 |
| Dechamps Law (Holdings) Ltd | Professional & scientific | 2020 |
| Dechamps Law Ltd | Professional & scientific | 2017 |
| Decibel Entertainment Ltd | Professional & scientific | 2025 |
| Decorative Holmes Limited | Construction | 2017 |
| Decorp Consulting Group Ltd | Financial services | 2017 |
| Decorp Property Holdings Ltd | Real estate | 2020 |
| Dedicated Accountants Ltd | Professional & scientific | 2020 |
| Dedicated Capital Allowances Limited | Professional & scientific | 2018 |
| Dedicated Group Ltd | Financial services | 2020 |
| Dedicated Lofts Ltd | Construction | 2026 |
| Dedicated Property Ltd | Real estate | 2015 |
| Deepgreen Consulting Limited | Real estate | 2002 |
| Deepview Solutions Limited | Professional & scientific | 2022 |
| Deerhurst Investments Limited | Construction | 2021 |
| Deerhurst Properties Limited | Real estate | 2005 |
| Deery Demolition Ltd | Construction | 2011 |
| Defence Cyber Certification Ltd | Information & communication | 2025 |
| Defence Cyber Ltd | Information & communication | 2025 |
| Defence Economics Limited | Information & communication | 2001 |
| Degioia Consultancy Ltd | Information & communication | 2019 |
| Degree Abroad Limited | Extraterritorial | 2020 |
| Deinking Solutions Limited | Professional & scientific | 2019 |
| Delafield Holdings Limited | Financial services | 1982 |
| Delagyle Fishing Limited | Agriculture & fishing | 1976 |
| Delahooke Feeds Services (2011) Ltd | Wholesale & retail | 2011 |
| Delancey (Cheltenham) Management Limited | Households | 2012 |
| Delapena Grinding & Industrial Abrasives Limited | Wholesale & retail | 2013 |
| Delapena Group Limited | Financial services | 2017 |
| Delapena Honing Equipment Limited | Manufacturing | 1985 |
| Delapena Sintered Products Limited | Professional & scientific | 2016 |
| Delegate That Ltd | Professional & scientific | 2012 |
| Delight Creative Limited | Professional & scientific | 2015 |
| Delinea UK Limited | Information & communication | 2018 |
| Deliveredbyethan Ltd | Transport & logistics | 2025 |
| Delivernow Ltd | Information & communication | 2017 |
| Deliverthat Project Management Limited | Professional & scientific | 2012 |
| Delivery.Gi (UK) Ltd | Wholesale & retail | 2025 |
| Dellifiori Aesthetics Ltd | Other services | 2025 |
| Delos Financial Limited | Professional & scientific | 2023 |
| Delport Holdco Limited | Financial services | 2025 |
| Delta Block (Rochester) Management Limited | Real estate | 1989 |
| Delta Graphics & Signs Limited | Manufacturing | 2000 |
| Delta Holdings (Pittville) Limited | Information & communication | 2017 |
| Delta Restaurants Ltd | Hospitality | 2023 |
| Delta Surveying Services Ltd | Professional & scientific | 2020 |
| Deltaworth Financial Limited | Professional & scientific | 2023 |