| Solace Services Ltd | Health & social care | 2019 |
| Solaplus Ltd | Financial services | 2008 |
| Solid UX Ltd | Information & communication | 2014 |
| Solo World Film Ltd | Information & communication | 2025 |
| Solutions PT Limited | Information & communication | 1985 |
| Solvite Limited | Extraterritorial | 1998 |
| Somerford Apartments Limited | Real estate | 2005 |
| Somerset Stained Glass Limited | Construction | 2012 |
| Sonas Capital Ltd | Administrative & support | 2021 |
| Sonas Property Ltd | Real estate | 2017 |
| Sonia's Beauty Lounge Ltd | Other services | 2021 |
| Soodeh Care Ltd | Professional & scientific | 2025 |
| Sooham Overseas Recruitment Ltd | Administrative & support | 2024 |
| Sophie Abrahams Psychology Limited | Education | 2023 |
| Sophie Ltd | Manufacturing | 2025 |
| Sopranos Grill Limited | Hospitality | 2025 |
| Sops Healthcare Ltd | Health & social care | 2016 |
| Soraya Consulting Limited | Administrative & support | 2019 |
| Sorted Properties Ltd | Real estate | 2020 |
| Source LAB Limited | Wholesale & retail | 2003 |
| South Cheshire Letting Solutions Limited | Real estate | 2021 |
| South Manchester Repairs Ltd | Other services | 2026 |
| South Manchester Rheumatologist Ltd | Health & social care | 2012 |
| South Manchester Sporting Ltd | Wholesale & retail | 2024 |
| South Manchester Sports Club Limited | Arts & recreation | 2007 |
| South Park Property Management Ltd | Real estate | 2016 |
| Southern Traders Ltd | Manufacturing | 2025 |
| Southmoor 23 Management Company Limited | Hospitality | 2004 |
| Southpoint(Didsbury)Flats Limited | Households | 1965 |
| Sovereign Business Transfer Limited | Real estate | 2008 |
| SOW Capital Ltd | Professional & scientific | 2012 |
| SP Contracts (Cheshire) Ltd | Households | 2011 |
| SP Decorating Northwest Limited | Other services | 2015 |
| SP Garden Maintenance Ltd | Administrative & support | 2016 |
| SP Leaflet Distribution Ltd | Information & communication | 2020 |
| SP Professional Decorating Ltd | Construction | 2020 |
| SP Properties (Cheshire) Ltd | Real estate | 2016 |
| Spaces & Places Limited | Administrative & support | 1998 |
| Spacestation.Com Limited | Information & communication | 2009 |
| Spar Scaffolding Ltd | Extraterritorial | 2016 |
| Spark Games Ltd | Information & communication | 2023 |
| Spark Regeneration Limited | Other services | 2010 |
| Spartan Music Ltd | Wholesale & retail | 2019 |
| Specialised Investigation Services (Holdings) Limited | Financial services | 2017 |
| Specialised Investigation Services Limited | Administrative & support | 2017 |
| Specialist Property Solutions Limited | Real estate | 2019 |
| Specialist Teachers for Dyslexia and Dyscalculia Ltd | Education | 2012 |
| Specifically Send Ltd | Education | 2023 |
| Spectragraphics (UK) Limited | Information & communication | 1986 |
| Spectre Systems Ltd | Construction | 2022 |
| Spectrum Medica Ltd | Health & social care | 2025 |
| Speech Leap Ltd | Health & social care | 2018 |
| Speedy Chicken & Shakes Ltd | Hospitality | 2023 |
| Speedy Parts Cheshire Ltd | Wholesale & retail | 2020 |
| Speedy Parts North West Ltd | Wholesale & retail | 2021 |
| Spencer-Ashcroft Investments Limited | Real estate | 1947 |
| Splendour Beauty Ltd | Other services | 2021 |
| Sports and Prestige Ltd. | Wholesale & retail | 2003 |
| Sports Massage Academy Ltd | Education | 2014 |
| Sportspoint Ltd | Education | 2026 |
| Spray Foam Removal Services Limited | Construction | 2025 |
| Spray Machine Repairs UK Limited | Manufacturing | 2021 |
| Spray Pro Upvc Ltd | Construction | 2019 |
| Springdale Psychological Services Ltd | Other services | 2018 |
| Springmeadow Properties Ltd | Real estate | 2025 |
| Sprowson Holdings Limited | Real estate | 2025 |
| SPV Consultancy Ltd | Administrative & support | 2017 |
| Spvtek Limited | Professional & scientific | 2022 |
| Squirrel Sports Limited | Professional & scientific | 2007 |
| SR Deals Ltd | Wholesale & retail | 2026 |
| SR Real Estate Investments Limited | Real estate | 2019 |
| Sr.Optometry Ltd | Wholesale & retail | 2023 |
| SRA Accountants Limited | Professional & scientific | 2020 |
| SRI Navadurga Health Care Ltd | Professional & scientific | 2020 |
| Srih Properties Limited | Real estate | 2022 |
| Sriyan Ltd | Wholesale & retail | 2024 |
| SRS Prime Ltd | Real estate | 2026 |
| SS Health Services Ltd | Health & social care | 2025 |
| Ssabi Decor Ltd | Extraterritorial | 2024 |
| Ssam Properties Limited | Real estate | 2021 |
| SSB Pharma Ltd | Wholesale & retail | 2023 |
| SSG Developments Ltd | Real estate | 2017 |
| SSG Invest Ltd | Real estate | 2018 |
| SSJ Property Solutions Ltd | Real estate | 2020 |
| ST Gabriel the Archangel Catholic Multi-Academy Trust | Education | 2012 |
| ST. Annes Pharmacy Limited | Extraterritorial | 1984 |
| STA Chem Ltd | Wholesale & retail | 2023 |
| Stable Homes (Residential) Limited | Real estate | 2025 |
| Stable Homes Limited | Real estate | 2023 |
| Stableford Avenue Management Limited | Households | 1980 |
| Staff Source Solutions Ltd | Public administration | 2024 |
| Staffordshire Locksmiths & Glazing Ltd | Construction | 2014 |
| Staffordshire Referral Marketing Limited | Administrative & support | 2012 |
| Stamford Park News Limited | Wholesale & retail | 2015 |
| Stanley House (CMA) Ltd | Construction | 2018 |
| Stanley Investments Ltd | Construction | 2014 |
| Stanley Land and Homes Limited | Construction | 2023 |
| Stanleyralph Ltd | Professional & scientific | 2025 |
| Stannard Management Limited | Real estate | 2009 |
| Stapl Manchester Limited | Wholesale & retail | 2025 |