| SK Virtuali Mokykla Ltd | Education | 2023 |
| SK2M Ventures Ltd | Real estate | 2024 |
| SK3M Ventures Ltd | Real estate | 2025 |
| Skagg Learning Consulting Ltd | Education | 2013 |
| Skillen Investments Ltd | Construction | 2024 |
| Skinat Tuition Limited | Education | 2023 |
| Skipngo Ltd | Water & waste | 2026 |
| Skkb Ltd | Real estate | 2024 |
| Skopia Ltd | Financial services | 2026 |
| Skunkhair Ltd | Other services | 2021 |
| Sky Blue Commercial Ltd | Real estate | 2022 |
| Sky Limo Ltd | Extraterritorial | 2010 |
| Sky Salon Ltd | Other services | 2024 |
| Sky the Limit Ltd | Financial services | 2025 |
| Skyfall International Ltd | Real estate | 2021 |
| Skylight EO Real Estate Limited | Real estate | 2023 |
| Skylink Technologies Limited | Information & communication | 2020 |
| Skytrek Flying School Limited | Arts & recreation | 2009 |
| SKZ Limited | Information & communication | 2009 |
| Slate 32 Productions Ltd | Information & communication | 2022 |
| Slayco Homes and Maintenance Limited | Construction | 2013 |
| Sliven Ltd | Transport & logistics | 2019 |
| SLM Construction Ltd | Construction | 2017 |
| SLN Facilities Services Limited | Construction | 2003 |
| Slow the Mind CIC | Education | 2024 |
| SLP Vegetation Solutions Ltd | Agriculture & fishing | 2016 |
| Slynex Limited | Information & communication | 2015 |
| SM Accounting Solution Ltd | Professional & scientific | 2018 |
| Small Catering Comp Ltd | Hospitality | 2025 |
| Smart Detection Ltd | Extraterritorial | 2015 |
| Smart Domain Group Limited | Information & communication | 2000 |
| Smart Express Services Limited | Transport & logistics | 2025 |
| Smart Glazzing Ltd | Construction | 2020 |
| Smart LAY Surfacing Ltd | Construction | 2026 |
| Smart Property Professionals Ltd | Real estate | 2018 |
| Smartcity Properties Limited | Real estate | 2025 |
| Smartcoats Decorations Ltd | Construction | 2024 |
| Smartex Business Consultancy Ltd | Information & communication | 2024 |
| Smartly Technologies Limited | Administrative & support | 2024 |
| Smartmove Rentals Ltd | Real estate | 2024 |
| Smat Business & Legal Consultancy Limited | Administrative & support | 2013 |
| SMD Maintenance Ltd | Construction | 2025 |
| SME Digital Inc Ltd | Professional & scientific | 2025 |
| Smeeth Metal Company Limited | Administrative & support | 1975 |
| Smelli Hair Ltd | Wholesale & retail | 2025 |
| SMG Broadcasting Ltd | Information & communication | 2010 |
| SMI Ventures Ltd | Financial services | 2021 |
| Smile Aesthetica UK Ltd | Health & social care | 2022 |
| Smiles Kitchen & Lounge Ltd | Wholesale & retail | 2025 |
| Smith and Goldsmith Limited | Wholesale & retail | 2016 |
| Smith Property Surveys Ltd | Professional & scientific | 2024 |
| Smith Textile Design Limited | Wholesale & retail | 2012 |
| Smiths of Kent Limited | Other services | 2014 |
| Smithy Farm Investments Ltd | Administrative & support | 2025 |
| Smoky Jollof Palace Ltd | Hospitality | 2025 |
| SN Nails Ltd | Other services | 2024 |
| Snalune Land and Private Property Investments Limited | Financial services | 2020 |
| SNI Builders & Maintenance Ltd | Construction | 2023 |
| SNM Medway Holdings Limited | Financial services | 2018 |
| SNM Medway Logistics Limited | Transport & logistics | 2019 |
| SNM Medway Residential Limited | Real estate | 2018 |
| Snowylogic Limited | Information & communication | 2025 |
| SNS Recruitment Ltd | Administrative & support | 2018 |
| SO Photography Limited | Manufacturing | 2025 |
| So-Ppe Ltd | Manufacturing | 2025 |
| Soarconcepts Limited | Manufacturing | 2025 |
| Social Staffing Solutions Limited | Administrative & support | 2023 |
| Soetan Holdings Limited | Information & communication | 2024 |
| Sofbele Ltd | Wholesale & retail | 2023 |
| Soffy Premium Services Ltd | Health & social care | 2023 |
| Sofiliyah Limited | Hospitality | 2019 |
| Soft Drink Machine Services Limited | Manufacturing | 2004 |
| SOL Partners Ltd | Other services | 2012 |
| Solaceworks Venture Limited | Health & social care | 2023 |
| Solar Grow Limited | Agriculture & fishing | 2014 |
| Solarch Ltd | Professional & scientific | 2025 |
| Solarvault Ltd | Manufacturing | 2021 |
| Sole Street Properties Limited | Real estate | 2014 |
| Solehealer Chiropody Ltd | Health & social care | 2010 |
| Solejourn Shoes Ltd | Manufacturing | 2023 |
| Solid Group Properties Limited | Real estate | 2023 |
| Solid Tech Global Ltd | Information & communication | 2026 |
| Solinparc Estates Limited | Construction | 2016 |
| Solinparc Limited | Construction | 2010 |
| Solly Hair & Beauty Ltd | Wholesale & retail | 2022 |
| Solo Consultancy Limited | Administrative & support | 2009 |
| Sologenius UK Limited | Information & communication | 2014 |
| Solsar Limited | Health & social care | 2023 |
| Somdera Limited | Real estate | 2019 |
| Somniscura Ltd | Information & communication | 2025 |
| SON Trading Ltd | Wholesale & retail | 2023 |
| Songhai Property Finance Limited | Extraterritorial | 2019 |
| Sonubi & Co UK Limited | Extraterritorial | 2019 |
| Sooper Foods Ltd | Wholesale & retail | 2019 |
| Sophie Victoria Webb Ltd. | Wholesale & retail | 2015 |
| Sora Sushi Ltd | Wholesale & retail | 2025 |
| SORAN2508 Limited | Transport & logistics | 2019 |
| Sota Performers Ltd | Arts & recreation | 2026 |
| Soul Collective CIC | Education | 2025 |
| Soul to Summit Ltd | Administrative & support | 2025 |