| Sharpe Heating Solutions Ltd | Construction | 2019 |
| Sharps Scaffolding Ltd | Construction | 2025 |
| Sharthk Ltd | Information & communication | 2018 |
| Shawn Samuele Ltd | Wholesale & retail | 2012 |
| Shaz Media Ltd | Professional & scientific | 2020 |
| SHD Companies Ltd | Health & social care | 2023 |
| Shea-Me Limited | Manufacturing | 2015 |
| Sheergreen Consulting Limited | Administrative & support | 2011 |
| Shekinah Glory Revival Ministries Ltd | Other services | 2020 |
| Shelladds Ltd | Professional & scientific | 2023 |
| Shen Investments Ltd | Real estate | 2012 |
| Shepherd Housing Ltd | Hospitality | 2024 |
| Shepherd Vehicle Repairs Limited | Wholesale & retail | 2010 |
| Shepherdhill Security Ltd | Administrative & support | 2025 |
| Sheppey Boats Ltd | Real estate | 2019 |
| SHH Estates Ltd | Real estate | 2022 |
| Shift Smart Ltd | Transport & logistics | 2024 |
| Shiloh Trading Limited | Wholesale & retail | 2024 |
| Shine Auto Aesthetics Ltd | Administrative & support | 2020 |
| Shine Care 24/7 Ltd | Administrative & support | 2014 |
| Shipon SES Ltd | Wholesale & retail | 2025 |
| Shocela Ltd | Real estate | 2008 |
| Shokar Properties Limited | Households | 2015 |
| Shop DE Saint Ltd | Wholesale & retail | 2026 |
| Shore Developments Ltd | Construction | 2016 |
| Shorebird (Kent) Ltd | Transport & logistics | 2019 |
| Shoresafe Solutions Limited | Manufacturing | 2026 |
| Short Brothers Aviation Heritage CIC | Arts & recreation | 2025 |
| Shortland Park Limited | Construction | 1978 |
| Shove and Sons Limited | Other services | 2018 |
| Showroom Detail UK Ltd | Other services | 2023 |
| Shqip Construction Ltd | Construction | 2019 |
| Shree Govind Enterprises Ltd | Hospitality | 2026 |
| Shreevaari Consulting Ltd | Information & communication | 2018 |
| SI Global Mart Ltd | Wholesale & retail | 2026 |
| SIA Property Investments Ltd | Real estate | 2024 |
| SIA Property Management Ltd | Real estate | 2025 |
| Sibling Property Ventures Limited | Real estate | 2025 |
| Sicario Solutions Limited | Transport & logistics | 2024 |
| Sick Brand Ltd | Wholesale & retail | 2018 |
| Sidcup and District Motor Cycle Club Limited | Arts & recreation | 2007 |
| Sidertech Developments Ltd | Real estate | 2012 |
| Sidolart Rails and Construction Ltd | Construction | 2023 |
| Sidorenko Holding Limited | Professional & scientific | 2018 |
| Sidorenko Property Ltd | Real estate | 2019 |
| Sigma Capital Ventures Limited | Wholesale & retail | 2024 |
| Sigma Change Ltd | Professional & scientific | 2021 |
| Signage and Print Solutions Ltd | Manufacturing | 2016 |
| Signature Capital Group Limited | Financial services | 2025 |
| Signature Surface Ltd | Construction | 2025 |
| Signgen Ltd | Manufacturing | 2020 |
| Significant Resources Limited | Health & social care | 2008 |
| Significant Trading Limited | Hospitality | 2012 |
| Signs & Design (Kent) Limited | Administrative & support | 2004 |
| SIK Decks Ltd | Wholesale & retail | 2025 |
| Sikxx Ltd | Wholesale & retail | 2026 |
| Silar Homes Ltd | Construction | 2025 |
| Silas Atwal Productions Ltd | Information & communication | 2024 |
| Sild Trading Ltd | Wholesale & retail | 2018 |
| Silence the Silencers Ltd | Hospitality | 2024 |
| Silvade Limited | Information & communication | 2010 |
| Silver Gardens RTM Company Limited | Households | 2011 |
| Silver Spoon Kitchen Chatham Ltd | Hospitality | 2024 |
| Silvermoon Group Limited | Financial services | 2017 |
| Simas Healthcare Ltd | Health & social care | 2021 |
| Simba Building Projects Limited | Construction | 2025 |
| Simiallsmiles Ltd | Wholesale & retail | 2021 |
| Simmons Enterprises Limited | Real estate | 2010 |
| Simmons Holdings Limited | Real estate | 2019 |
| Simon Beer Multitrade Ltd | Construction | 2022 |
| Simon Burnop Building & Carpentry Limited | Construction | 2014 |
| Simon Burnop Construction Ltd | Construction | 2020 |
| Simon Logistics Limited | Other services | 2012 |
| Simon Woodrow Carpentry Ltd | Construction | 2017 |
| Simple Care Connect Limited | Health & social care | 2018 |
| Simplified Trade Finance Limited | Other services | 2018 |
| Simply Finance Limited | Administrative & support | 2004 |
| Simply Red Fire Solutions Ltd | Construction | 2025 |
| Simply SIX Limited | Health & social care | 2019 |
| Simva Carpentry and Construction (SCC) Ltd | Construction | 2014 |
| Sinam Limited | Health & social care | 2018 |
| Sinclair Family Holdings Limited | Administrative & support | 2022 |
| Sinclair Partnership Ltd | Professional & scientific | 2020 |
| Sinden Surveying Solutions Ltd | Administrative & support | 2025 |
| Sing Fit Limited | Arts & recreation | 2019 |
| Singularis Global Ltd | Professional & scientific | 2025 |
| Sirphee Healthcare Ltd | Wholesale & retail | 2022 |
| Sisters Bite Limited | Manufacturing | 2026 |
| Sittingbourne Bathrooms Ltd | Wholesale & retail | 2024 |
| Sittingbourne Hikes LLP | | 2024 |
| Sival Global Ltd | Wholesale & retail | 2023 |
| Sixteen New Road Limited | Households | 2016 |
| SJ Arboriculture and Grounds Maintenance Ltd | Agriculture & fishing | 2025 |
| SJA Holdings Kent Ltd | Households | 2024 |
| SJB Management Ltd | Information & communication | 2020 |
| Sjgw Limited | Construction | 2025 |
| SJN Business Ltd | Information & communication | 2024 |
| SJP Real Estate Limited | Real estate | 2023 |
| SJS Fibre Ltd | Construction | 2017 |
| SJW Project Engineering Ltd | Construction | 2019 |