| Omni Fire Protection Limited | Administrative & support | 2020 |
| Omni Hub Limited | Construction | 2019 |
| Omni Joinery Solutions Limited | Construction | 2021 |
| ON Route Recovery Limited | Transport & logistics | 2025 |
| P Gall Ltd | Construction | 2026 |
| P L P C Holdings Limited | Other services | 2022 |
| Pagani Trading Ltd | Extraterritorial | 2025 |
| Painhas Energy Ltd | Construction | 2021 |
| Palazzo Buildworks Limited | Construction | 2011 |
| Palazzo Living Limited | Construction | 2024 |
| Palazzo RF Limited | Financial services | 2025 |
| Peacock Builders (Carluke) Limited | Construction | 1982 |
| Penguin Hot Tubs Limited | Wholesale & retail | 2013 |
| Perfect Press Carluke Limited | Other services | 2026 |
| Pharmadaddy Ltd | Information & communication | 2024 |
| Phoenix Healthcare Solutions Ltd | Health & social care | 2024 |
| Photoflash Travel Ltd. | Administrative & support | 2010 |
| Pinpointjoinery Ltd | Construction | 2024 |
| Pinzgauer Limited | Extraterritorial | 2011 |
| Pinzgauer Technik Ltd | Extraterritorial | 2003 |
| PMC Machine Tools Ltd | Manufacturing | 2016 |
| Pmcc Projects Ltd | Real estate | 2017 |
| PMW Property Ltd | Real estate | 2026 |
| Power Line Protected Crossings Limited | Extraterritorial | 1994 |
| Power Lines, Pipes and Cables Limited | Construction | 1977 |
| Powertec Generators Ltd | Manufacturing | 2010 |
| PRC Planning Limited | Professional & scientific | 2015 |
| Precise SA Limited | Real estate | 2021 |
| Premier Door Solutions Limited | Manufacturing | 2022 |
| Presca Limited | Wholesale & retail | 2024 |
| Pringle Carluke Payroll Limited | Administrative & support | 2014 |
| Pro-Tech Fire and Security Ltd | Public administration | 2025 |
| Protrac Ltd | Construction | 2019 |
| Protrol Instrumentation Ltd. | Professional & scientific | 1995 |
| Pullman Assist Fleet Services Ltd | Wholesale & retail | 2025 |
| Quality IT & Web Solutions Limited | Information & communication | 2018 |
| R 26 Services Limited | Other services | 2024 |
| R D X Global Ltd | Wholesale & retail | 2025 |
| Rail Products Holdings Limited | Financial services | 2019 |
| Rail Products UK Ltd. | Other services | 2013 |
| RAM 266 Limited | Professional & scientific | 2020 |
| RCB Homes Ltd | Real estate | 2020 |
| Real Tactical Solutions Ltd | Wholesale & retail | 2024 |
| Red C Productions Ltd. | Information & communication | 2013 |
| Red Tavern Limited | Hospitality | 2019 |
| Redline Electronics Ltd | Other services | 2018 |
| Reframes Solutions Ltd | Professional & scientific | 2013 |
| Remo Volpe Joinery & Building Services Ltd | Construction | 2022 |
| Residential and Commercial Elecrical Services Ltd | Construction | 2024 |
| Retro Cars Limited | Wholesale & retail | 2015 |
| Reynard Nursery Ltd | Agriculture & fishing | 2007 |
| RFP Industrial Ltd | Wholesale & retail | 2026 |
| RJL Joinery Services Ltd | Manufacturing | 2025 |
| RJW Mortgages Limited | Financial services | 2023 |
| Rmca Logistics & Distribution Ltd | Wholesale & retail | 2023 |
| RND Developments Limited | Real estate | 2025 |
| Roadrunner Engine Carbon Cleaning Carluke Ltd | Wholesale & retail | 2019 |
| Roar Marketing Ltd | Professional & scientific | 2026 |
| Rock Vale (Scotland) Ltd | Households | 2025 |
| Rookbridge Consulting Limited | Professional & scientific | 2023 |
| Rosche Limited | Wholesale & retail | 2024 |
| Rosebank Nursery Ltd | Agriculture & fishing | 2013 |
| Rossleigh Developments Limited | Construction | 2017 |
| Rossleigh Motor Co Ltd | Wholesale & retail | 2018 |
| Rosso Carluke Ltd | Real estate | 2025 |
| RPJ Besp-Oak Interiors Ltd | Construction | 2022 |
| RS Motorsport by Robert Stuart Ltd | Manufacturing | 2020 |
| RT Dickson Joinery Ltd | Construction | 2015 |
| Runway Studios Makeup Ltd | Other services | 2017 |
| Ruvi Services Ltd | Transport & logistics | 2025 |
| S Gallagher Joinery Ltd | Manufacturing | 2022 |
| Saberwars Ltd | Wholesale & retail | 2023 |
| Saltire Play Ltd | Construction | 2024 |
| Sask Retail Ltd | Wholesale & retail | 2019 |
| SC Legacy Estates Ltd | Real estate | 2025 |
| Scot Rock Walks - Geology Tours Ltd | Administrative & support | 2024 |
| Scotia Capital Limited | Professional & scientific | 2014 |
| Scotia Energy Ltd | Construction | 2012 |
| Scotia Energy Renewables Limited | Construction | 2020 |
| Scott Leghorn Transport Ltd | Transport & logistics | 2020 |
| Scott Young Industrial Solutions Ltd | Manufacturing | 2026 |
| Scott's Scran Catering Ltd | Hospitality | 2025 |
| SCSMX5 Ltd | Wholesale & retail | 2021 |
| Serendipity Carluke Ltd | Wholesale & retail | 2025 |
| Serenity Beauty and PMU Limited | Other services | 2023 |
| Shift Media Productions Ltd | Information & communication | 2021 |
| Shine Youth Music Theatre | Arts & recreation | 2010 |
| SHN Foods Limited | Other services | 2018 |
| Shoreway Limited | Wholesale & retail | 1999 |
| Shutter Doctor Ltd | Construction | 2026 |
| Silverbirch Garden Centre(Crossford)Limited | Wholesale & retail | 1976 |
| Simons Snax Limited | Hospitality | 2026 |
| SKB North Ltd | Financial services | 2025 |
| Sleek and Studded Ltd | Other services | 2026 |
| SLL13 Limited | Construction | 2025 |
| SMC Rentals Ltd | Real estate | 2026 |
| Smithycroft Superstore Ltd | Wholesale & retail | 2015 |
| Snappy Occasions Limited | Hospitality | 2023 |
| Soft Drinks Direct Limited | Wholesale & retail | 2020 |
| Spaniels Gifts Ltd | Wholesale & retail | 2025 |