| Story Homes Limited | Construction | 1988 |
| Story Newton Energy Limited | Energy | 2025 |
| Story Nuclear Limited | Extraterritorial | 2022 |
| Story Painting (North West) Limited | Extraterritorial | 2008 |
| Story Plant Limited | Administrative & support | 2007 |
| Story Rail Limited | Extraterritorial | 1999 |
| Story Technical Services Ltd | Hospitality | 2021 |
| Story Trustees Limited | Professional & scientific | 2003 |
| Stowford PUB Company Limited | Hospitality | 2013 |
| STR Assets Ltd | Real estate | 2023 |
| STR Express Ltd | Hospitality | 2024 |
| Strafford Search Partners Ltd | Administrative & support | 2024 |
| STRAITS1183 Limited | Construction | 2025 |
| Stratheden Properties Ltd | Real estate | 2026 |
| Strawberry Grange (Cockermouth) Flat Management Company Limited | Real estate | 2022 |
| Strawberry Grange (Cockermouth) Management Company Limited | Households | 2017 |
| Streamline.Uk.Com Limited | Professional & scientific | 2005 |
| Strickland Eggs Limited | Agriculture & fishing | 2010 |
| Strickland Management Limited | Professional & scientific | 1987 |
| Stringtheory Limited | Information & communication | 2001 |
| Stroquhan Estate Limited | Real estate | 1988 |
| Stuart Armstrong & Co Limited | Professional & scientific | 2002 |
| Stuart Young Heating Services Limited | Construction | 2019 |
| Studio Property (Carlisle) Limited | Real estate | 2017 |
| Studiographic Cumbria Limited | Professional & scientific | 2023 |
| Sugar Time Carlisle Ltd | Hospitality | 2025 |
| Sulley's Trading Ltd | Manufacturing | 2021 |
| Sultan Supreme (Keswick) Ltd | Hospitality | 2025 |
| Sulwath Limited | Construction | 2009 |
| Summers & MAY Ltd | Professional & scientific | 2018 |
| Summit Town Planning Ltd | Professional & scientific | 2020 |
| Sunbeam Integrated Services Limited | Households | 2023 |
| Sunkissed Carlisle Limited | Other services | 2024 |
| Sunnydown Consulting Limited | Information & communication | 2016 |
| Sunrise Property Ventures Ltd | Real estate | 2026 |
| Sunshine Skyway Structures Limited | Other services | 2017 |
| Supp Shack Limited | Wholesale & retail | 2018 |
| Supply IT Site Services Limited | Other services | 2013 |
| Surface Restore (Cumbria) Ltd | Construction | 2023 |
| Sursum Tuus Limited | Extraterritorial | 2006 |
| Susan Watson Limited | Health & social care | 2015 |
| Sussex Mowers Limited | Manufacturing | 2022 |
| Sustainable Groundworks Solutions Ltd | Construction | 2021 |
| Sutcliffe House Limited | Households | 1986 |
| Sutton Court (Cumbria) Management Company Limited | Households | 1993 |
| Svella AI Solutions Limited | Information & communication | 2024 |
| Svella Asset Services Limited | Administrative & support | 2021 |
| Svella Connect Limited | Construction | 2021 |
| Svella Energy Limited | Construction | 2022 |
| Svella Estates Limited | Construction | 2021 |
| Svella Infrastructure Group Limited | Financial services | 2021 |
| Svella Infrastructure Solutions Limited | Construction | 2022 |
| Svella Nominee 2 Limited | Financial services | 2024 |
| Svella Nominee Limited | Financial services | 2021 |
| Svella PLC | Financial services | 2018 |
| Svella Technologies Limited | Financial services | 2024 |
| Svella VSP Limited | Financial services | 2022 |
| Svellex Limited | Transport & logistics | 2024 |
| SW11 Gym Ltd | Arts & recreation | 2022 |
| Swan Esco Limited | Construction | 2024 |
| Swan Heat Network Limited | Construction | 2024 |
| Swan Street 1963 Limited | Extraterritorial | 2014 |
| Swanndri New Zealand (UK) Limited | Wholesale & retail | 2018 |
| Swarbrick Associates (U.K.) Limited | Professional & scientific | 2014 |
| Swarbrick Associates Limited | Professional & scientific | 2006 |
| Sweet Retreat Carlisle Ltd | Wholesale & retail | 2024 |
| Sweet Save Ltd | Wholesale & retail | 2018 |
| Sweet Tooth Group Ltd | Professional & scientific | 2020 |
| Swift Automation & Control Systems Limited | Information & communication | 1997 |
| Swift Automation Limited | Information & communication | 2009 |
| Swift Shift Removals and Storage Limited | Transport & logistics | 2021 |
| Swiftconsult Limited | Real estate | 2007 |
| Swifts Newsagents Limited | Wholesale & retail | 2015 |
| Switch Communications Ltd | Other services | 2017 |
| Switchenergia Ltd | Agriculture & fishing | 2015 |
| SWM (NW) Ltd | Other services | 2025 |
| Sycamore Park Garden Centre Limited | Extraterritorial | 1995 |
| SYD & Co (Cumbria) Ltd | Wholesale & retail | 2020 |
| Syke Construction Limited | Construction | 2009 |
| Syke Road Garage Limited | Wholesale & retail | 2016 |
| Synectic Property Solutions Ltd | Wholesale & retail | 2012 |
| Synergy Home Improvements Ltd | Administrative & support | 2016 |
| Synergy Safety (Cumbria) Ltd | Administrative & support | 2023 |
| Synergy-Fabtech Limited | Energy | 2018 |
| Synthesys Defence Limited | Information & communication | 2018 |
| Synthesys Defence Systems (SDS) Limited | Information & communication | 1987 |
| Syntramarket Ltd | Information & communication | 2026 |
| Syphapse Limited | Health & social care | 2026 |
| System Developments Ltd | Construction | 2025 |
| System Hydraulics Limited | Manufacturing | 1995 |
| System Information Technology Limited | Information & communication | 2001 |
| System Learning Limited | Education | 2024 |
| System People Limited | Administrative & support | 2002 |
| System Training Limited | Extraterritorial | 2016 |
| T & Y Ltd | Real estate | 2021 |
| T & Z Watson Ltd | Extraterritorial | 2024 |
| T E & P W Eckersley Limited | Agriculture & fishing | 2015 |
| T Forsyth & Sons Roofing Limited | Construction | 2021 |
| T G & K Fisher | Agriculture & fishing | 2002 |
| T Grice Roofing Ltd | Construction | 2026 |