| ST Andrew's Gardens (Thursby) Management Company Limited | Real estate | 2023 |
| ST Andrews View (Thursby) Management Company Limited | Households | 2017 |
| ST Anns Management Company Limited | Households | 2012 |
| ST Bridgets (Brigham) Management Company Limited | Households | 2019 |
| ST Conveyancing Ltd | Professional & scientific | 2023 |
| ST Cuthberts (Wigton) Management Company Limited | Households | 2017 |
| ST Georges Hall and Lodge Limited | Health & social care | 2018 |
| ST Josephs Gardens Management Company Ltd | Real estate | 2006 |
| ST Margaret Mary's Parish Community Centre Ltd | Other services | 2007 |
| ST Martin's Green (Kirklevington) Management Company Limited | Real estate | 2020 |
| ST Mungos Close (Dearham) Management Company Limited | Households | 2013 |
| ST Nicholas Arms Ltd | Hospitality | 2025 |
| ST Pauls Medical Services Limited | Health & social care | 2000 |
| ST. Gabriels Court Limited | Households | 1986 |
| ST. Nich Limited | Hospitality | 2018 |
| ST. Nicholas Galleries Limited | Wholesale & retail | 1988 |
| ST. Paul's Mews Limited | Professional & scientific | 1988 |
| ST. Pauls Square (Carlisle) Limited | Households | 1990 |
| Stacey's Coaches Limited | Transport & logistics | 2001 |
| Stacker Vending Ltd | Administrative & support | 2009 |
| Stackerz Grill Bar Ltd | Hospitality | 2021 |
| Staffordshire Agri Services Limited | Agriculture & fishing | 2022 |
| Stagedright Community & Education Limited | Education | 2012 |
| Stagedright Productions Limited | Arts & recreation | 2004 |
| Stags Head Farms Limited | Agriculture & fishing | 2025 |
| Stahlschmidt Medical Limited | Health & social care | 2016 |
| Stalholt Capital Limited | Financial services | 2025 |
| Stalski Construction Ltd | Construction | 2022 |
| Stan Palmer Limited | Wholesale & retail | 2000 |
| Standingstone Renewables Limited | Energy | 2017 |
| Stanley Childcare Limited | Education | 2003 |
| Stanley's Bar & Restaurant Ltd | Hospitality | 2022 |
| Stanshawes Care Home Limited | Health & social care | 2019 |
| Stanwix Community Association | Real estate | 2009 |
| Stanwix News Ltd | Wholesale & retail | 2007 |
| Stanwix School | Education | 2014 |
| Stanwix Tandoori Restaurant Limited | Hospitality | 1998 |
| Star Barbers CA1 Ltd | Other services | 2025 |
| Starmarsh Fashions Limited | Financial services | 1995 |
| Starr Advisory UK Ltd | Information & communication | 2026 |
| Starride Consulting Services Ltd | Extraterritorial | 2023 |
| Stash Engineering Solutions Ltd | Professional & scientific | 2026 |
| Station Road & Southfield Management Company Limited | Administrative & support | 2003 |
| Stay Deansgate Limited | Hospitality | 2006 |
| Stay North Management Ltd | Real estate | 2026 |
| STE Forster Ltd | Construction | 2019 |
| Steel (NW) Ltd | Transport & logistics | 2026 |
| Stenhouse Ltd | Professional & scientific | 2022 |
| Stephen Frizell Limited | Agriculture & fishing | 2003 |
| Stephen Little Limited | Construction | 2013 |
| Stephens Brothers Limited | Administrative & support | 1957 |
| Steppings Music Limited | Arts & recreation | 2011 |
| Steve Jeffrey Limited | Agriculture & fishing | 2014 |
| Steve KER TM Ltd | Construction | 2024 |
| Steven Brown Building Contractors Limited | Construction | 2007 |
| Steven Little Productions Limited | Information & communication | 2006 |
| Steven Mattinson Ltd | Construction | 2009 |
| Steven Wilson Limited | Wholesale & retail | 2004 |
| Stew & Oyster (Trading) Limited | Manufacturing | 2009 |
| Stewart Leisure Limited | Extraterritorial | 2024 |
| Stewart Williamson Limited | Real estate | 1997 |
| STF Investments Limited | Construction | 2022 |
| Sticky Bits (Carlisle) C.I.C. | Hospitality | 2013 |
| Stillwater Whisky Co. Ltd | Manufacturing | 2020 |
| Stirling Engineering & Manufacturing Ltd | Manufacturing | 2022 |
| Stirling Property Development Group Limited | Real estate | 2025 |
| Stobart Bros Limited | Hospitality | 2021 |
| Stobart Capital Limited | Professional & scientific | 2017 |
| Stockuk Ltd | Real estate | 2024 |
| Stolle Europe Limited | Manufacturing | 1988 |
| Stone Circle Developments Cumbria Limited | Construction | 2024 |
| Stone Eden Enterprises Limited | Education | 2016 |
| Stone Eden Nursery School Limited | Education | 2014 |
| Stone Harrison Limited | Hospitality | 2011 |
| Stone OWL Estates Limited | Wholesale & retail | 2017 |
| Stonebridge Masonry Co. Limited | Construction | 2006 |
| Stonedale Management Company Limited | Real estate | 2025 |
| Stonegarth 1973 Limited | Extraterritorial | 2015 |
| Stonehaven Engineering Services (Cumbria) Limited | Other services | 2012 |
| Storage Carlisle Limited | Hospitality | 2013 |
| Stories Publishing Ltd | Information & communication | 2025 |
| Stories Recordings Limited | Information & communication | 2024 |
| Storm Electrical Services Ltd | Construction | 2009 |
| Storm Shield Painting and Roofing Limited | Construction | 2022 |
| Stormproof Roofing & Repairs Ltd | Construction | 2026 |
| Stors Taxi Limited | Transport & logistics | 2024 |
| Story 123 Limited | Extraterritorial | 2022 |
| Story Capital Investments Limited | Financial services | 2007 |
| Story Construction Limited | Extraterritorial | 2007 |
| Story Contracting Holdings Limited | Financial services | 2017 |
| Story Decorating Group Limited | Construction | 2008 |
| Story Decorators Limited | Extraterritorial | 2008 |
| Story Electrical Limited | Manufacturing | 2019 |
| Story Energy Limited | Financial services | 2022 |
| Story Future Five Limited | Extraterritorial | 2023 |
| Story Future Four Limited | Extraterritorial | 2023 |
| Story Future One Limited | Energy | 2023 |
| Story Future Three Limited | Extraterritorial | 2023 |
| Story Future Two Limited | Extraterritorial | 2023 |
| Story Geotech Limited | Extraterritorial | 2021 |